Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension

Circulation

Volumn 102, Issue 22, 2000, Pages 2765-2773

  Matsumura, Y ^a   Kuro, T ^a   Kobayashi, Y ^a   Konishi, F ^a   Takaoka, M ^a   Wessale, J L ^a   Opgenorth, T J ^a   Gariepy, C E ^a   Yanagisawa, M ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Endothelin; Hypertension; Receptors

Indexed keywords

ATRASENTAN; DEOXYCORTICOSTERONE ACETATE; DOPAMINE BETA MONOOXYGENASE; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; GENE DELETION; GENE EXPRESSION; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; KIDNEY INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; TISSUE INJURY; TREATMENT OUTCOME;

EID: 0034727697     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.22.2765     Document Type: Article

References (34)

1. Endothelin: Potential role in hypertension and vascular hypertrophy
2. Antihypertensive effects of a novel endothelin-A receptor antagonist in rats
3. Antihypertensive effect of an endothelin receptor antagonist in DOCA-salt spontaneously hypertensive rats
4. Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats: Evidence for a role of endothelin in vascular hypertrophy
5. Role of endothelin-1 and the ET(A) receptor in the maintenance of deoxycorticosterone acetate-salt-induced hypertension
6. Effects of the endothelin ET(A)-receptor antagonist FR139317 on development of hypertension and cardiovascular hypertrophy in deoxycorticosterone acetate-salt hypertensive rats
7. Different contribution of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats
8. Endothelin and endothelin receptor antagonists in cardiovascular disease
9. Effect of chronic ET(A)-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats
10. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color
11. Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts
12. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease
13. Salt-sensitive hypertension in endothelin-B receptor-deficient rats
14. Pharmacological characterization of A-127722: An orally active and highly potent ET(A)-selective receptor antagonist
15. Conversion of big ET-1 in the rat lung: Role of phosphoramidon-sensitive endothelin-converting enzyme
16. ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain
17. Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ET(B) receptor-deficient rats
18. ET(A) receptor blockade attenuates the hypertension but not renal dysfunction in DOCA-salt rats
19. Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats
20. Nephroprotection of an ET(A)-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats
21. The role of ET(B) receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ET(B) receptor antagonist Ro 46-8443
22. Endothelin ET(B) receptor-mediated action on systemic and renal hemodynamics and urine formation in deoxycorticosterone acetate-salt-induced hypertensive rats
23. Increased eudothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats
24. Increased expression of endothelin-1 gene in blood vessels of deoxycorticosterone acetate-salt hypertensive rats
25. ET(A) receptor blockade prevents increased tissue endothelin vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension
26. ET(A) receptor-mediated role of endothelin in the kidney of DOCA-salt hypertensive rats
27. Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones
28. Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney
29. Potential contribution of endothelin to renal abnormalities in glycerol-induced acute renal failure in rats
30. The emerging concept of vascular remodeling
31. The selective endothelin ET(A) receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis
32. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
33. Characterization of canine renal endothelin receptor subtypes and their function
34. The renal basis for salt sensitivity in hypertension