Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: Cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol

Biochemical Pharmacology

Volumn 61, Issue 12, 2001, Pages 1517-1529

  Palom, Yolanda ^a   Belcourt, Michael F ^b   Tang, Li Qun ^b   Mehta, Shilpi S ^b   Sartorelli, Alan C ^b   Pritsos, Chris A ^c   Pritsos, Karen L ^c   Rockwell, Sara ^b   Tomasz, Maria ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEVADA   (United States)

Author keywords

2,7 Diaminomitosene; Bioreductive; Dicumarol; DNA adducts; Metabolism; Mitomycin C; Tumor cells

Indexed keywords

2,7 DIAMINOMITOSENE; CELL DNA; DICOUMAROL; DRUG METABOLITE; GUANINE; MITOMYCIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST TUMOR; CELL SURVIVAL; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG UPTAKE; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL DIVISION; CELL-FREE SYSTEM; DICUMAROL; DNA ADDUCTS; DRUG INTERACTIONS; ENZYME INHIBITORS; MAMMARY NEOPLASMS, ANIMAL; MICE; MITOMYCIN; MITOMYCINS; NADH DEHYDROGENASE; RADIOPHARMACEUTICALS; TRITIUM; TUMOR CELLS, CULTURED; XANTHINE DEHYDROGENASE;

EID: 0035877170     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00609-8     Document Type: Article

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