-
2
-
-
0030591663
-
DNA adducts from chemotherapeutic agents
-
Lawley, P. D., and Philips, D. H. (1996) DNA adducts from chemotherapeutic agents. Mutat. Res. 355, 13-40.
-
(1996)
Mutat. Res.
, vol.355
, pp. 13-40
-
-
Lawley, P.D.1
Philips, D.H.2
-
3
-
-
0004204228
-
-
Oxford University Press, Oxford, U.K
-
Peckham, M., Pinedo, B., and Veronesi, U., Eds. (1995) Oxford textbook of oncology, Oxford University Press, Oxford, U.K.
-
(1995)
Oxford Textbook of Oncology
-
-
Peckham, M.1
Pinedo, B.2
Veronesi, U.3
-
4
-
-
0025189891
-
Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2
-
Springer, C. J., Antoniw, P., Bagshawe, K. D., Searle, F., and Bisset, G. M. F. (1990) Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. J. Med. Chem. 33, 677-681.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 677-681
-
-
Springer, C.J.1
Antoniw, P.2
Bagshawe, K.D.3
Searle, F.4
Bisset, G.M.F.5
-
5
-
-
8944233863
-
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal xenografts
-
Blakey, D. C., Burke, P. J., Davies, D. H., Dowell, R. I., East, S. J., Eckersley, K. P., Fitton, J. E., McDaid, J., Melton, R. G., Niculescu-Duvaz, I. A., Pinder, P. E., Sharma, S. K., Wright, A. F., and Springer, C. J. (1996) ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal xenografts. Cancer Res. 56, 3287-3292.
-
(1996)
Cancer Res
, vol.56
, pp. 3287-3292
-
-
Blakey, D.C.1
Burke, P.J.2
Davies, D.H.3
Dowell, R.I.4
East, S.J.5
Eckersley, K.P.6
Fitton, J.E.7
McDaid, J.8
Melton, R.G.9
Niculescu-Duvaz, I.A.10
Pinder, P.E.11
Sharma, S.K.12
Wright, A.F.13
Springer, C.J.14
-
6
-
-
0030024847
-
Antibody-enzyme conjugates for cancer therapy
-
Melton, R. G., and Sherwood, R. F. (1996) Antibody-enzyme conjugates for cancer therapy. J. Natl. Cancer Inst. 88, 153-165.
-
(1996)
J. Natl. Cancer Inst.
, vol.88
, pp. 153-165
-
-
Melton, R.G.1
Sherwood, R.F.2
-
7
-
-
0029588221
-
The choice of prodrugs for gene directed enzyme prodrug therapy of cancer
-
Connors, T. A. (1995) The choice of prodrugs for gene directed enzyme prodrug therapy of cancer. Gene Ther. 2, 702-709.
-
(1995)
Gene Ther
, vol.2
, pp. 702-709
-
-
Connors, T.A.1
-
8
-
-
0028848101
-
Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs
-
Blakey, D. C., Davies, D. H., Dowell, R. L. East, S. J., Burke, P. J., Sharma, S. K., Springer, C. J., Mauger, A. B., and Melton, R. G. (1995) Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs. Br. J. Cancer 72, 1083-1088.
-
(1995)
Br. J. Cancer
, vol.72
, pp. 1083-1088
-
-
Blakey, D.C.1
Davies, D.H.2
Dowell, R.L.3
East, S.J.4
Burke, P.J.5
Sharma, S.K.6
Springer, C.J.7
Mauger, A.B.8
Melton, R.G.9
-
9
-
-
0023142479
-
Immunological detection of DNA damage caused by melphalan using monoclonal antibodies
-
Tilby, M. J., Styles, J. M., and Dean, C. J. (1987) Immunological detection of DNA damage caused by melphalan using monoclonal antibodies. Cancer Res. 47, 1542-1546.
-
(1987)
Cancer Res
, vol.47
, pp. 1542-1546
-
-
Tilby, M.J.1
Styles, J.M.2
Dean, C.J.3
-
10
-
-
0029142953
-
A monoclonal antibody that recognises alkalistabilised melphalan-DNA adducts and its application in immunofluorescence microscopy
-
Tilby, M. J., McCartney, H., Cordell, J., Frank, A. J., and Dean, C. J. (1995) A monoclonal antibody that recognises alkalistabilised melphalan-DNA adducts and its application in immunofluorescence microscopy. Carcinogenesis 16, 1895-1901.
-
(1995)
Carcinogenesis
, vol.16
, pp. 1895-1901
-
-
Tilby, M.J.1
McCartney, H.2
Cordell, J.3
Frank, A.J.4
Dean, C.J.5
-
11
-
-
0027411418
-
Application of a sensitive immunoassay to the study of DNA adducts formed in peripheral blood mononuclear cells of patients undergoing high-dose melphalan therapy
-
Tilby, M. J., Newell, D. R., Viner, C., Selby, P. J., and Dean, C. J. (1993) Application of a sensitive immunoassay to the study of DNA adducts formed in peripheral blood mononuclear cells of patients undergoing high-dose melphalan therapy. Eur. J. Cancer 29A, 681-686.
-
(1993)
Eur. J. Cancer
, vol.29 A
, pp. 681-686
-
-
Tilby, M.J.1
Newell, D.R.2
Viner, C.3
Selby, P.J.4
Dean, C.J.5
-
12
-
-
0029744782
-
Detection and quantification of melphalan-DNA adducts at the single cell level in hemopoietic tumor cells
-
Frank, A. J., Proctor, S. J., and Tilby, M. J. (1996) Detection and quantification of melphalan-DNA adducts at the single cell level in hemopoietic tumor cells. Blood 88, 977-984.
-
(1996)
Blood
, vol.88
, pp. 977-984
-
-
Frank, A.J.1
Proctor, S.J.2
Tilby, M.J.3
-
13
-
-
0025239832
-
Alkylation of DNA by melphalan in relation to immunoassay of melphalanDNA adducts: Characterization of mono-alkylated and crosslinked products from reaction of melphalan with dGMP and GMP
-
Tilby, M. J., Lawley, P. D., and Farmer, P. B. (1990) Alkylation of DNA by melphalan in relation to immunoassay of melphalanDNA adducts: characterization of mono-alkylated and crosslinked products from reaction of melphalan with dGMP and GMP. Chem.-Biol. Interact. 73, 183-194.
-
(1990)
Chem.-Biol. Interact.
, vol.73
, pp. 183-194
-
-
Tilby, M.J.1
Lawley, P.D.2
Farmer, P.B.3
-
14
-
-
0027514969
-
Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking
-
Osborne, M. R., and Lawley, P. D. (1993) Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking. Chem.-Biol. Interact. 89, 49-60.
-
(1993)
Chem.-Biol. Interact.
, vol.89
, pp. 49-60
-
-
Osborne, M.R.1
Lawley, P.D.2
-
15
-
-
0029119506
-
Products from alkylation of DNA in cells by melphalan: Human soft tissue sarcoma cell line RD and Escherichia coli WP2
-
Osborne, M. R., Lawley, P. D., Crofton-Sleigh, C., and Warren, W. (1995) Products from alkylation of DNA in cells by melphalan: human soft tissue sarcoma cell line RD and Escherichia coli WP2. Chem.-Biol. Interact. 97, 287-296.
-
(1995)
Chem.-Biol. Interact.
, vol.97
, pp. 287-296
-
-
Osborne, M.R.1
Lawley, P.D.2
Crofton-Sleigh, C.3
Warren, W.4
-
16
-
-
0005942065
-
DNA damage and mutagenesis induced by nitrogen mustards
-
Povirk, L. F., and Shuker, D. E. (1994) DNA damage and mutagenesis induced by nitrogen mustards. Mutat. Res. 318, 205-226.
-
(1994)
Mutat. Res.
, vol.318
, pp. 205-226
-
-
Povirk, L.F.1
Shuker, D.E.2
-
18
-
-
37049060048
-
Aryl-2-halogenoalkylamines. Part XDC. Some N,N-di-2-chloroethylamino-phenyl- And -phenylalkyl-hydantoins and related amino-acids
-
Connors, T. A., Ross, W. C. J., and Wilson, J. G. (1960) Aryl-2-halogenoalkylamines. Part XDC. Some N,N-di-2-chloroethylamino-phenyl- and -phenylalkyl-hydantoins and related amino-acids. J. Chem. Soc., 2994-3007.
-
(1960)
J. Chem. Soc.
, pp. 2994-3007
-
-
Connors, T.A.1
Ross, W.C.J.2
Wilson, J.G.3
-
19
-
-
3643056838
-
Studies on the chemotherapy of leukemia
-
Burchenal, J. H., Lester, R. A., Riley, J. B., and Rhoads, C. P. (1948) Studies on the chemotherapy of leukemia. Cancer 1, 399-412.
-
(1948)
Cancer
, vol.1
, pp. 399-412
-
-
Burchenal, J.H.1
Lester, R.A.2
Riley, J.B.3
Rhoads, C.P.4
-
20
-
-
3643051661
-
Chemotherapy of leukemia. III. Further studies on the effect of nitrogen mustards and related compounds on transmitted mouse leukemia
-
Burchenal, J. H., Burchenal, J. R., and Johnston, S. F. (1951) Chemotherapy of leukemia. III. Further studies on the effect of nitrogen mustards and related compounds on transmitted mouse leukemia. Cancer 4, 353-356.
-
(1951)
Cancer
, vol.4
, pp. 353-356
-
-
Burchenal, J.H.1
Burchenal, J.R.2
Johnston, S.F.3
-
21
-
-
3643142418
-
Cyto-active amino-acids and peptides. Part V. Derivatives of p-amino- And p-mercapto-phenylalanine
-
Bergel, F., and Stock, J. A. (1959) Cyto-active amino-acids and peptides. Part V. Derivatives of p-amino- and p-mercapto-phenylalanine. J. Chem. Soc., 90-97.
-
(1959)
J. Chem. Soc.
, pp. 90-97
-
-
Bergel, F.1
Stock, J.A.2
-
22
-
-
0344492183
-
Specificity of p53 elevation and its role in drug action: P53 induction by measured levels of specific DNA adducts
-
Gould, K. A., McCartney, H., Lawley, P. D., Golding, B. T., and Tilby, M. J. (1997) Specificity of p53 elevation and its role in drug action: p53 induction by measured levels of specific DNA adducts. Proc. Am. Assoc. Cancer Res. 38, 2.
-
(1997)
Proc. Am. Assoc. Cancer Res.
, vol.38
, pp. 2
-
-
Gould, K.A.1
McCartney, H.2
Lawley, P.D.3
Golding, B.T.4
Tilby, M.J.5
-
23
-
-
0025877161
-
Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase
-
Ponti, M., Forrow, S. M., Souhami, R. L., D'Incalci, M., and Hartley, J. A. (1991) Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase. Nucleic Acids Res. 19, 2929-2933.
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 2929-2933
-
-
Ponti, M.1
Forrow, S.M.2
Souhami, R.L.3
D'Incalci, M.4
Hartley, J.A.5
-
24
-
-
0022616154
-
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards
-
Mattes, W. B., Hartley, J. A., and Kohn, K. W. (1986) DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards. Nucleic Acids Res. 14, 2971-2987.
-
(1986)
Nucleic Acids Res
, vol.14
, pp. 2971-2987
-
-
Mattes, W.B.1
Hartley, J.A.2
Kohn, K.W.3
-
25
-
-
0020026702
-
Comparative studies of DNA cross-linking and cytotoxicity in Burkitt's lymphoma cell lines treated with cisdiamminedichloroplatinum(II) and L-phenylalanine mustard
-
Ducore, J. M., Erickson, L. C., Zwelling, L. A., Laurent, G., and Kohn, K. W. (1982) Comparative studies of DNA cross-linking and cytotoxicity in Burkitt's lymphoma cell lines treated with cisdiamminedichloroplatinum(II) and L-phenylalanine mustard. Cancer Res. 42, 897-902.
-
(1982)
Cancer Res
, vol.42
, pp. 897-902
-
-
Ducore, J.M.1
Erickson, L.C.2
Zwelling, L.A.3
Laurent, G.4
Kohn, K.W.5
-
26
-
-
0026646849
-
The reaction of melphalan with deoxyguanosine and deoxyguanylic acid
-
Osborne, M. R., and Lawley, P. D. (1992) The reaction of melphalan with deoxyguanosine and deoxyguanylic acid. Chem.Biol. Interact. 84, 189-198.
-
(1992)
Chem.Biol. Interact.
, vol.84
, pp. 189-198
-
-
Osborne, M.R.1
Lawley, P.D.2
-
27
-
-
3643123661
-
Effects upon tumours of various haloalkylarylamines
-
Haddow, A., Kon, G. A. R., and Ross, W. C. J. (1948) Effects upon tumours of various haloalkylarylamines. Nature 162, 824-825.
-
(1948)
Nature
, vol.162
, pp. 824-825
-
-
Haddow, A.1
Kon, G.A.R.2
Ross, W.C.J.3
-
28
-
-
0023920917
-
Degradation of melphalan in vitro: Rationale for the use of continuous exposure in chemosensitivity assays
-
Bosanquet, A. G., and Bird, M. C. (1988) Degradation of melphalan in vitro: rationale for the use of continuous exposure in chemosensitivity assays. Cancer Chemother. Pharmacol. 21, 211-215.
-
(1988)
Cancer Chemother. Pharmacol.
, vol.21
, pp. 211-215
-
-
Bosanquet, A.G.1
Bird, M.C.2
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