The role of the factor X activation peptide: A deletion mutagenesis approach

Thrombosis and Haemostasis

Volumn 88, Issue 5, 2002, Pages 756-762

  Rudolph, Amy E ^a   Mullane, Michael P ^a   Porche Sorbet, Rhonda ^a   Daust, Heather A ^a   Miletich, Joseph P ^a  

^a PFIZER INC   (United States)

Author keywords

Activation peptide; Deletion; Factor X

Indexed keywords

ALANINE; BLOOD CLOTTING FACTOR 10 ACTIVATION PEPTIDE; BLOOD CLOTTING FACTOR 10 COAGULANT PROTEIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 9A; ENZYME; ENZYME PRECURSOR; LIPID; PEPTIDE; PROTEIN; SNAKE VENOM; THROMBIN; THROMBOPLASTIN; UNCLASSIFIED DRUG; BLOOD CLOTTING FACTOR 10; CARBOHYDRATE; LIPOSOME;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOREGULATION; CARBOHYDRATE ANALYSIS; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVATION; MUTAGENESIS; PLASMA FACTOR; PRIORITY JOURNAL; REGULATORY MECHANISM; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; GENE DELETION; GENETICS; HOMEOSTASIS; HUMAN; KINETICS; METABOLISM; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; CARBOHYDRATES; CATALYSIS; FACTOR VIIA; FACTOR X; FACTOR XA; HOMEOSTASIS; HUMANS; KINETICS; LIPOSOMES; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; SEQUENCE DELETION; THROMBOPLASTIN;

EID: 0036847508     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613298     Document Type: Article

References (36)

1. Leytus SP, Foster DC, Kurachi K, Davie EW. Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C. Biochemistry 1986; 25: 5098-102.
2. Jesty J, Spencer AK, Nemerson Y. The mechanism of activation of factor X. Kinetic control of alternative pathways leading to the formation of activated factor X. J Biol Chem 1974; 249: 5614-22.
3. Pfeiffer RA, Ott R, Gilgenkrantz S, Alexandre P. Deficiency of coagulation factors VII and X associated with deletion of a chromosome 13 (q34). Evidence from two cases with 46,XY,t(13;Y)(q11;q34). Hum Genet 1982; 62: 358-60.
4. Nemerson Y, Bach R. Tissue factor revisited. Prog Hemostas Thromb 1982; 6: 237-61.
5. Nemerson Y. Tissue factor and hemostasis. Blood 1988; 71: 1-8.
6. Mann KG, Jenny RJ, Krishnaswamy S. Cofactor proteins in the assembly and expression of blood clotting enzyme complexes. Annu Rev Biochem 1988; 57: 915-56.
7. DiScipio RG, Hermodson MA, Davie EW. Activation of human factor X (Stuart factor) by a protease from Russell's viper venom. Biochemistry 977; 16: 5253-60.
8. Brandstetter H, Kuhne A, Bode W, et al. X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition. J Biol Chem 1996; 271: 29988-92.
9. Padmanabhan K, Padmanabha KP, Tulinsky A, et al. Structure of human des(1-45) factor Xa at 2.2 A resolution. J Mol Biol 1993; 232: 947-66.
10. Duffy EJ, Lollar P. Intrinsic pathway activation of factor X and its activation peptide-deficient derivative, factor Xdes-143-191. J Biol Chem 1992; 267: 7821-7.
11. Lollar P, Parker CG, Kajenski PJ, Litweller RD, Fass DN. Degradation of coagulation proteins by an enzyme from Malayan pit viper (Agkistrodon rhodostoma) venom. Biochemistry 1987; 26: 7627-36.
12. Iino M, Takeya H, Nishioka J, Nakagaki T, Tamura K, Suzuki K. The role of human factor X activation peptide in activation of factor X by factor IXa. J Biochem (Tokyo) 1994; 116: 335-40.
13. Baugh RJ, Krishnaswamy, S. Role of the activation peptide domain in human factor X activation by the extrinsic Xase complex. J Biol Chem 1996: 271: 16126-34.
14. Jackson CM, Hanahan DJ. Studies on bovine factor X. II. Characterization of purified factor X. Observations on some alterations in zone oelectrophoresis and chromatographic behavior occurring during purification. Biochemistry 1968; 7: 4506-17.
15. Jackson CM. Characterization of two glycoprotein variants of bovine factor X and demonstration that the factor X zymogen contains two polypeptide chains. Biochemistry 1972; 11: 4873-81.
16. Fujikawa K. Thompson AR, Legaz ME, Davie EW. Biological properties of bovine factor X (Stuart Factor). Fed Proc Fed Amer Soc Exp Biol 1971; 30: 1075.
17. Sinha U, Wolf DL. Carbohydrate residues modulate the activation of coagulation factor X. J Biol Chem 1993; 268: 3048-51.
18. Inou K, Moria T. Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X. Eur J Biochem 1993; 218: 153-63.
19. Chavin SI, Weidner SM. Blood clotting factor IX. Loss of activity after cleavage of sialic acid residues. J Biol Chem 1984; 259: 3387-3390.
20. Bharadwaj D, Harris RJ, Kisiel S, Smith KJ. Enzymatic removal of sialic acid from human factor IX and factor X has no effect on their coagulant activity. J Biol Chem 1995; 270: 6537-42.
21. Rudolph AE, Porche-Sorbet R, Miletich JP. Substitution of asparagine for arginine 347 of recombinant factor Xa markedly reduces factor Va binding. Biochemistry 2000; 39: 2861-67.
22. Rudolph AE, Mullane MP, Porche-Sorbet RP et al. Factor X St. Louis II. Identification of a glycine substitution at residue 7 and characterization of the recombinant protein. J Biol Chem 1996; 271: 28601-6.
23. Rudolph AE, Mullane MP, Porche-Sorbet RP, Miletich JP. Expression, purification, and characterization of recombinant human factor X. Protein Exp Purif 1997; 10: 373-8.
24. Cook BC, Rudolph AE, Kurumbail RG, Porche-Sorbet RMiletich JP. Directed glycosylation of human coagulation factor X at residue 333. Insight into factor Va-dependent prothrombin catalysis. J Biol Chem 2000; 275: 38774-9.
25. Rudolph AE, Porche-Sorbet R, Miletich JP. Definition of a factor Va binding site in factor Xa. J Biol Chem 2001; 276: 5123-8.
26. Jiskoot W, Teerlink T, Beuvery EC, Crommelin DJ. Preparation of liposomes via detergent removal from mixed micelles by dilution. The effect of bilayer composition and process parameters on liposomes characteristics. Pharm Weekbl Sci 1986; 8: 259-65.
27. Kisiel W, Hermodson MA, Davie EW. Factor X activating enzyme from Russell's viper venom: isolation and characterization. Biochemistry 1976; 15: 4901-6.
28. Fass DN, Knutson GJ, Katzmann JA. Monoclonal antibodies to porcine factor VIII coagulant and their use in the isolation of active coagulant protein. Blood 1992; 59: 594-600.
29. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
30. Grahan FL, van der Eb AJ. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973; 52: 456-67.
31. Kuzmic P. Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. Anal. Biochem 1996; 237: 260-73.
32. Myrmel KH, Lundblad RL, Mann KG. Characteristics of the association between prothrombin fragment 2 and alpha-thrombin. Biochemistry 1976; 15: 1767-73.
33. Luckow EA, Lyons DA, Ridgewa TM, Esmon CT, Laue TM. Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction: analysis by analytical ultracentrifugation. Biochemistry 1989; 28: 2348-54.
34. Esmon CT, Jackson CM. The conversion of prothrombin to thrombin. IV. The function of the fragment 2 region during activation in the presence of factor V. J Biol Chem 1974; 249: 7791-7.
35. Furie BC, Furie B, Gottlieb AJ, Williams WJ. Activation of bovine factor X by the venom coagulant protein of Vipera russelli: complex formation of the activation fragments. Biochim Biophys Acta 1974; 365: 121-32.
36. Shah AM, Kisiel W, Foster DC, Nelsestuen GL. Manipulation of the membrane binding site of vitamin K-dependent proteins: enhanced biological function of human factor VII. Proc Nat. Acad Sci 1998; 95: 4229-34.