Total N-nitroso compounds and their precursors in hot dogs and in the gastrointestinal tract and feces of rats and mice: Possible etiologic agents for colon cancer

Journal of Nutrition

Volumn 132, Issue 11 SUPPL., 2002, Pages

  Mirvish, Sidney S ^a,b   Haorah, James ^a   Zhou, Lin ^a   Clapper, Marge L ^c   Harrison, Kathryn L ^e   Povey, Andrew C ^d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e NONE

Author keywords

7 methyldeoxyguanosine; Beef; Colitis; Feces; Hot dogs; N nitroso compounds

Indexed keywords

AMINO ACID DERIVATIVE; DEOXYGUANOSINE; DEXTRAN SULFATE; NITROSO DERIVATIVE; PEPTIDE DERIVATIVE;

ADSORPTION; AMES TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER RISK; COLITIS; COLON CANCER; CONFERENCE PAPER; CONTROLLED STUDY; DESORPTION; DIETARY INTAKE; DUODENUM; FECES; FEMALE; FOOD COMPOSITION; GASTROINTESTINAL TRACT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NITROSATION; NONHUMAN; RAT; STOMACH;

ANIMALIA; CANIS FAMILIARIS;

EID: 0036847406     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.11.3526s     Document Type: Conference Paper

References (18)

1. Mirvish, S.S. (1995) Role of N-nitroso compounds (NOC) in etiology of gastric, esophageal, nasopharyngeal and bladder cancer, and contribution to cancer of known exposures to NOC. Cancer Lett. 93: 17-48.
2. Hecht, S. S. & Hoffmann, D. (1989) The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv. 8: 273-294.
3. Sandhu, M. S., White, I. R. & McPherson, K. (2001) Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: A meta-analytical approach. Cancer Epidemiol. Biomarkers Prev. 10: 439-446.
4. Truswell, A. S. (2001) Meat consumption and colorectal cancer: Critique of Norat and Riboli's review. Nutr. Rev. 59: 375-377.
5. Bunin, G. R. (1998) Maternal diet during pregnancy and risk of brain tumors in children. Int. J. Cancer Suppl. 11: 23-25.
6. Peters, J. M., Preston-Martin, S., London, S. J., Bowman, J. D., Buckley, J. D. & Thomas, D. C. (1994) Processed meats and risk of childhood leukemia (California, U.S.A.). Cancer Causes Control 5: 195-202.
7. Van Dam, R. M., Willett, W. C., Rimm, E. B., Stampfer, M. J. & Hu, F. B. (2002) Dietary fat and meat intake in relation to risk of type 2 diabetes in man. Diabetes Care 25: 417-424.
8. Haorah, J., Zhou, L., Wang, X., Xu, G. & Mirvish, S. S. (2001) Determination of total N-nitroso compounds and their precursors in frankfurters, fresh meat, dried salted fish, sauces, tobacco and tobacco smoke particulates. J. Agric. Food Chem. 49: 6068-6078.
9. Mirvish, S. S. (1975) Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence. Toxicol. Appl. Pharmacol. 31: 325-351.
10. Zhou, L., Haorah, J., Wang, X. & Mirvish, S. S. (2001) Purification of a fraction rich in N-nitroso compound precursors and tentative partial identification of an N-nitroso compound precursor in frankfurters. Proc. Am. Assoc. Cancer Res. 42: 604 (abs.).
11. Pool, B. L., Röper, H., Röper, S. & Romruen, K. (1984) Mutagenicity studies on N-nitrosated products of the Maillard browning reaction: N-nitrosofructose-amino acids. Food Chem. Toxicol. 22: 797-801.
12. Pignatelli, B., Malaveille, C., Friesen, M., Hautefeuille, A., Bartsch, H., Piskorska, D. & Descsotes, G. (1987) Synthesis, structure-activity relationships and a reaction mechanism for mutagenic N-nitroso derivatives of glycosylamines and Amadori compounds: Model substances for N-nitrosated early Maillard reaction products. Food Chem. Toxicol 25: 669-680.
13. Bingham, S. (1998) High-meat diets and cancer risk. Proc. Nutr. Soc. 58: 243-248.
14. Haorah, J., Clapper, M. L. & Mirvish, S. S. (2001) Studies on N-nitroso compounds (NOC) in gastrointestinal tract (GIT) and feces of rats and mice, including effect of colitis. J. Nutr. 131: 3145s.
15. Mirvish, S. S., Haorah, J., Zhou, L. & Clapper, M. L. (2002) N-Nitroso compound (NOC) levels in gastrointestinal tract (GIT) of rats and in feces of mice with colitis and mice fed hot dogs and beef. Proc. Am. Assoc. Cancer Res. 43: 1039.
16. Cooper, H. S., Everley, L., Chang, W.-C., Pheiffer, G., Lee, B., Murthy, S. & Clapper, M. L. (2001) The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium induced colitis. Gastroenterology 121: 1407-1416.
17. Hughes, R., Cross, A. J., Pollock, J. R. A. & Bingham, S. (2001) Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation. Carcinogenesis 22: 199-202.
18. Harrison, K. L., Wood, M., Lees, N. P., Hall, C. N., Margison, G. P. & Povey, A. C. (2001) Development and application of a sensitive and rapid immunoassay for the quantitation of N7-methyldeoxyguanosine in DNA samples. Chem. Res. Toxicol. 14: 295-301.