Intestinal cytochrome P450 and response to rifampicin in rabbits

Japanese Journal of Pharmacology

Volumn 82, Issue 3, 2000, Pages 232-239

  Nakamura, Takahiro ^b   Okada, Keizo ^a,b   Nagata, Kiyoshi ^b   Yamazoe, Yasushi ^b  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Induction; Intestinal mucosa; Rifampicin; Testosterone 6 hydroxylation

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; DEXTROMETHORPHAN; PHENYTOIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIFAMPICIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG HYDROXYLATION; DRUG MECHANISM; DRUG OXIDATION; MALE; NONHUMAN; RABBIT; WESTERN BLOTTING;

EID: 0034115808     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.82.232     Document Type: Article

References (32)

1. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC and Nebert DW: P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6, 1-42, (1996)
2. Gonzalez FJ and Gelboin HV: Human cytochromes P450: evolution and cDNA-directed expression. Environ Health Perspect 98, 81-85 (1992)
3. Kaminsky LS and Fasco MJ: Small intestinal cytochromes P450. Crit Rev Toxicol 21, 407-422 (1991)
4. de Waziers I, Cugnenc PH, Yang CS, Leroux JP and Beaune PH: Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J Pharmacol Exp Ther 253, 387-394 (1990)
5. Wu S, Moomaw CR, Tomer KB, Falck JR and Zeldin DC: Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem 271, 3460-3468 (1996)
6. Watkins PB, Wrighton SA, Schuetz EG, Molowa DT and Guzelian PS: Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 80, 1029-1036 (1987)
7. Kolars JC, Schmiedlin-Ren P, Schuetz JD, Fang C and Watkins PB: Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. J Clin Invest 90, 1871-1878 (1992)
8. Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrighton SA, Merion RM and Watkins PB: CYP3A gene expression in human gut epithelium. Pharmacogenetics 4, 247-259 (1994)
9. Kivisto KT, Bookjans G, Fromm MF, Griese EU, Munzel P and Kroemer HK: Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue. Br J Clin Pharmacol 42, 387-389 (1996)
10. Perucca E, Grimaldi R, Frigo GM, Sardi A, Monig H and Ohnhaus EE: Comparative effects of rifabutin and rifampicin on hepatic microsomal enzyme activity in normal subjects. Eur J Clin Pharmacol 34, 595-599 (1988)
11. Ged C, Rouillon JM, Pichard L, Combalbert J, Bressot N, Bories P, Michel H, Beaune P and Maurel P: The increase in urinary excretion of 6β-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction. Br J Clin Pharmacol 28, 373-387 (1989)
12. Wrighton SA, Schuetz EG, Watkins PB, Maurel P, Barwick J, Bailey BS, Hartle HT, Young B and Guzelian P: Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat. Mol Pharmacol 28, 312-321 (1985)
13. Oesch F, Arand M, Benedetti MS, Castelli MG and Dostert P: Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyl-transferase superfamilies in female rat liver. J Antimicrob Chemother 37, 1111-1119 (1996)
14. Yamazoe Y, Shimada M, Kamataki T and Kato R: Effects of hypophysectomy and growth hormone treatment on sex-specific forms of cytochrome P-450 in relation to drug and steroid metabolisms in rat liver microsomes. Jpn J Pharmacol 42, 371-382 (1986)
15. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685 (1970)
16. Towbin H, Staehelin T and Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76, 4350-4354 (1979)
17. Yamazoe Y, Murayama N, Shimada M, Yamauchi K, Nagata K, Imaoka S, Funae Y and Kato R: A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6β-hydroxylase in untreated rat livers: reconstitution of the activity with microsomal lipids. J Biochem 104, 785-790 (1988)
18. Oesch F, Wagner H, Platt KL and Arand M: Improved sample preparation for the testosterone hydroxylation assay using disposable extraction columns. J Chromatogr 582, 232-235 (1992)
19. Broly F, Libersa C, Lhermitte M, Bechtel P and Dupuis B: Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver. Br J Clin Pharmacol 28, 29-36 (1989)
20. Kapetanovic IM and Kupferberg HJ: Analysis of p-hydroxyphenytoin in microsomal reactions by high-performance liquid chromatography with electrochemical detection. J Chromatogr 310, 418-423 (1984)
21. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193, 265-275 (1951)
22. Omura T and Sato R: The carbon monoxide-binding pigment of liver microsomes. J Biol Chem 239, 2370-2378 (1964)
23. Phillips AH and Langdon RG: Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies. J Biol Chem 237, 2652-2660 (1962)
24. 5 and NADPH-cytochrome c reductase from rat liver microsomes. J Biochem 67, 249-257 (1970)
25. Doecke CJ, Sansom LN and McManus ME: Phenytoin 4-hydroxylation by rabbit liver P450IIC3 and identification of orthologs in human liver microsomes. Biochem Biophys Res Commun 166, 860-866 (1990)
26. Reik LM, Levin W, Ryan DE and Thomas PE: Immunochemical relatedness of rat hepatic microsomal cytochromes P-450c and P-450d. J Biol Chem 257, 3950-3957 (1982)
27. Shimizu Y, Kusunose E, Kikuta Y, Arakawa T, Ichihara K and Kusunose M: Purification and characterization of two new cytochrome P-450 related to CYP2C subfamily from rabbit small intestine microsomes. Biochim Biophys Acta 1339, 268-276 (1997)
28. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, Okuda K and Neben W: The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 12, 1-51 (1993)
29. Lange R, Balny C and Maurel P: Inductive and repressive effects of rifampicin on rabbit liver microsomal cytochrome P-450. Biochem Pharmacol 33, 2771-2776 (1984)
30. Kolars JC, Schmiedlin-Ren P, Dobbins WO, Schuetz J, Wrighton SA and Watkins PB: Heterogeneity of cytochrome P450IIIA expression in rat gut epithelia. Gastroenterology 102, 1186-1198 (1992)
31. Hall PM, Stupans I, Burgess W, Birkett DJ and McManus ME: Immunohistochemical localization of NADPH-cytochrome P450 reductase in human tissues. Carcinogenesis 10, 521-530 (1989)
32. McKinnon RA, Burgess WM, Hall PM, Abdul-Aziz Z and McManus ME: Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids. Cancer Res 52, 2108-2113 (1992)