Apoptosis induced by Pseudomonas aeruginosa in antigen presenting cells is diminished by genetic modification with CD40 ligand

Pediatric Research

Volumn 52, Issue 5, 2002, Pages 636-644

  Worgall, Stefan ^a   Martushova, Katherine ^a   Busch, Annette ^a   Lande, Leah ^a   Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CASPASE INHIBITOR; CD40 LIGAND;

ANIMAL CELL; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BACTERIAL COLONIZATION; BRONCHUS MUCOSA; CELL ACTIVATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DENDRITIC CELL; DNA MODIFICATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; T LYMPHOCYTE;

EID: 0036840006     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200211000-00006     Document Type: Article

References (41)

1. Davis PB, Drumm M, Konstan MW 1996 Cystic fibrosis. Am J Respir Crit Care Med 154:1229-1256
2. Govan JR, Deretic V 1996 Microbial pathogenesis in cystic fibrosis: Mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 60:539-574
3. Tummler B, Kiewitz C 1999 Cystic fibrosis: An inherited susceptibility to bacterial respiratory infections. Mol Med Today 5:351-358
4. Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP 1998 The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 280:295-298
5. Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP 2000 Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407:762-764
6. Bezdicek P, Crystal RG 1997 Pulmonary macrophages. In: Crystal RG, West JB, Weibel ER, P.J. Barnes (eds) The Lung: Scientific Foundation. Lippincott-Raven Inc., Philadelphia, pp 859-875
7. McWilliam AS, Nelson DJ, Holt PG 1995 The biology of airway dendritic cells. Immunol Cell Biol 73:405-413
8. McWilliam AS, Stumbles PA, Holt PG. Dendritic Cells in the Lung 1999 In: Lopez MT, Thomson AW (eds) Dendritic Cells: Biology and Clinical Applications. Academic Press, San Diego, pp 123-140
9. Reynolds HY 1997 Integrated Host Defenses Against Infection. In: Crystal RG, West JB, Weibel RE, Barnes PJ (eds) The Lung: Scientific Foundations. Lippincott-Raven, Inc., Philadelphia, pp 2353-2366
10. Bruno TF, Woods DE, Mody CH 2000 Exoenzyme S from Pseudomonas aeruginosa induces apoptosis in T lymphocytes. J Leukoc Biol 67:808-816
11. Coburn J, Frank DW 1999 Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system. Infect Immun 67:3151-3154
12. Grassme H, Kirschnek S, Riethmueller J, Riehle A, von Kurthy G, Lang F, Weller M, Gulbins E 2000 CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 290:527-530
13. Hauser AR, Engel JN 1999 Pseudomonas aeruginosa induces type-III-secretion-mediated apoptosis of macrophages and epithelial cells. Infect Immun 67:5530-5537
14. Rajan S, Cacalano G, Bryan R, Ratner AJ, Sontich CU, van Heerckeren A, Davis P, Prince A 2000 Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells: Analysis of the effects of cystic fibrosis transmembrane conductance regulator dysfunction and bacterial virulence factors. Am J Respir Cell Mol Biol 23:304-312
15. Valente E, Assis MC, Alvim IM, Pereira GM, Plotkowski MC 2000 Pseudomonas aeruginosa induces apoptosis in human endothclial cells. Microb Pathog 29:345-356
16. Zaborina O, Dhiman N, Ling CM, Kostal J, Holder IA, Chakrabarty AM 2000 Secreted products of a nonmucoid Pseudomonas aeruginosa strain induce two modes of macrophage killing: External-ATP-dependent. P2Z-receptor-mediated necrosis and ATP-independent, caspase-mediated apoptosis. Microbiology 146:2521-2530
17. Donnenberg MS 2000 Pathogenic strategies of enteric bacteria. Nature 406:768-774
18. Gao LY, Kwaik YA 2000 The modulation of host cell apoptosis by intracellular bacterial pathogens. Trends Microbiol 8:306-313
19. Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A 1999 The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci USA 96:2396-2401
20. Monack DM, Mecsas J, Bouley D, Falkow S 1998 Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. J Exp Med 188:2127-2137
21. Yrlid U, Wick MJ 2000 Salmonella-induced apoptosis of infected macrophages results in presentation of a bacteria-encoded antigen after uptake by bystander dendritic cells. J Exp Med 191:613-624
22. Zychlinsky A, Sansonetti PJ 1997 Apoptosis as a proinflammatory event: What can we learn from bacteria-induced cell death? Trends Microbiol 5:201-204
23. Grewal IS, Flavell RA 1998 CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 16:111-135
24. Kehry MR 1996 CD40-mediated signaling in B cells. Balancing cell survival, growth, and death. J Immunol 156:2345-2348
25. Esche C, Gambotto A, Satoh Y, Gerein V, Robbins PD, Watkins SC, Lotze MT, Shurin MR 1999 CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth. Eur J Immunol 29:2148-2155
26. Kikuchi T, Worgall S, Singh R, Moore MA, Crystal RG 2000 Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells. Nat Med 6:1154-1159
27. Song W, Kong HL, Carpenter H, Torii H, Granstein R, Raffi S, Moore MA. Crystal RG 1997 Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity. J Exp Med 186:1247-1256
28. Russi TJ, Crystal RG 1997 Bronchoalveolar Lavage. In: Crystal RG, West JB, Weibel ER, P.J. Bames (eds) The Lung: Scientific Foundation. Lippincott-Raven Inc., Philadelphia, pp 371-382
29. Kikuchi T, Crystal RG 1999 Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells. Hum Gene Ther 10:1375-1387
30. Hersh J, Crystal RG, Bewig B 1995 Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector. Gene Ther 2:124-131
31. Rosenfeld MA, Siegfried W, Yoshimura K, Yoneyama K, Fukayama M, Stier LE, Paakko PK, Gilardi P, Stratford-Perricaudet LD, Perricaudet M, Jallat S, Pavirani A, Lecocq J-P, Crystal RG 1991 Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science 252:431-434
32. Rosenfeld MA, Yoshimura K, Trapnell BC, Yoneyama K, Rosenthal ER, Dalemans W, Fukayama M, Bargon J, Stier LE, Strafford-Perricaudet L, Perricaudet M, Guggino WB, Pavirani A, Lecocq J-P, Crystal RG 1992 In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium, Cell 68:143-155
33. Crystal RG, McElvaney NG, Rosenfeld MA, Chu CS, Mastrangeli A, Hay JG, Brody SL, Jaffe HA, Eissa NT, Danel C 1994 Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat Genet 8:42-51
34. Tosi MF, Zakem H, Berger M 1990 Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J Clin Invest 86:300-308
35. Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP, Frank DW 1999 Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. Nat Med 5:392-398
36. Dacheux D, Toussaint B, Richard M, Brochier G, Croize J, Attree I 2000 Pseudomonas aeruginosa cystic fibrosis isolates induce rapid, type III secretion-dependent, but ExoU-independent, oncosis of macrophages and polymorphonuclear neutrophils. Infect Immun 68:2916-2924
37. Zaborina O, Misra N, Kostal J, Kamath S, Kapatral V, El-Idrissi ME, Prabhakar BS, Chakrabarty AM 1999 P2Z-Independent and P2Z receptor-mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients. Infect Immun 67:5231-5242
38. Sawa T, Ohara M, Kurahashi K, Twining SS, Frank DW, Doroques DB, Long T, Gropper MA, Wiener-Kronish JP 1998 In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. Infect Immun 66:3242-3249
39. Eamshaw WC, Martins LM, Kaufmann SH 1999 Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68:383-424
40. Ashany D, Savir A, Bhardwaj N, Elkon KB 1999 Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. J Immunol 163:5303-5311
41. Worgall S, Kikuchi T, Singh R, Martushova K, Lande L, Crystal RG 2001 Protection against pulmonary infection with Pseudomonas aeruginosa following immunization with P. aeruginosa-pulsed dendritic cells. Infect Immun 69:4521-4527