Hyperhomocysteinemia and endothelial function in young subjects: Effects of vitamin supplementation

Clinical Cardiology

Volumn 25, Issue 11, 2002, Pages 495-501

  Hirsch, Sandra ^a   De La Maza, M Pia ^a   Petermann, Margarita ^a   Barrera, Gladys ^a   Gattas, Vivian ^a   Escobar, Edgardo ^a   Yañez, Paulina ^b   Glasinovic, Andrea ^b   Bunout, Daniel ^c  

^a UNIVERSITY OF CHILE   (Chile)

^b Section of Gastroenterology   (Chile)

^c HOSPITAL SAN BORJA ARRIARÁN   (Chile)

Author keywords

Endothelial dysfunction; Folic acid; Homocysteine; Vitamin B12

Indexed keywords

ANTITHROMBIN III; CYANOCOBALAMIN; FIBRINOGEN; FOLIC ACID; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN; PLACEBO; PROTEIN C; PROTEIN S; PROTHROMBIN; PYRIDOXINE; THROMBIN;

ADULT; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENDOTHELIUM; FOLIC ACID BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; RANDOMIZED CONTROLLED TRIAL; REVIEW; ULTRASOUND; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 0036829911     PISSN: 01609289     EISSN: None     Source Type: Journal    
DOI: 10.1002/clc.4960251105     Document Type: Review

References (32)

1. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE: Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-236
2. Selhub J, Jacques PF, Bostom AG, D'Agostino R, Wilson P, Belanger AJ, O'Leary DH, Wolf PA, Schaefer EJ, Rosenberg I: Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995;332:286-291
3. Bostom AG, Rosenberg IH, Silbershatz H, Jacques PF, Selhub J, D'Agostino RB, Wilson PW, Wolf PA: Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women. Arch Intern Med 1999;24:1077-1080
4. Danesh J, Lewington S: Plasma homocysteine and coronary heart disease: Systematic review of published epidemiological studies. J Card Vasc Risk 1998;5:229-232
5. Hankey GJ, Eikelboom JW: Homocysteine and vascular disease. Lancet 1999;354:407-413
6. Welch GN, Loscalzo J: Mechanisms of disease: Homocysteine atherothrombosis. N Engl J Med 1998;338:1042-1050
7. Jakubowski H: Protein homocysteinylation: Possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 1999;13:2277-2283
8. Galasse SP, Selwyn AP, Ganz P: Atherosclerosis: Risk factors and the vascular endothelium. Am Heart J 1996;131:379-384
9. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE: Endothelium dependent dilatation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994;24:1468-1474
10. Lentz SR, Sobey CG, Piegors DJ, Bhopatkar M, Faraci FM, Malinow MR: Vascular dysfunction in monkeys with diet induced hyperhomocysteinemia. J Clin Invest 1996;98:24-29
11. Bellamy MF, McDowel IFW, Ramsey MW, Brownlee M, Bones C, Newcombe RG, Lewis MJ: Hyperhomocysteinemia after oral methionine load acutely impairs endothelial function in healthy adults. Circulation 1998;98:1848-1852
12. Nappo F, De Rosa N, Marfella R, De Lucia D, Ingrosso D, Pema AF, Farzati B, Giugliano D: Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. J Am Med Assoc 1999;281:2113-2118
13. Vemeulen EGJ, Stehouver CDA, Twisk JWR, van den Berg M, de Jong SC, Mackaay AJC, van Campen CMC: Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: A randomized, placebocontrolled trial. Lancet 2000;355:517-522
14. Esterbauer H, Striegl G, Puhl H, Rotheneder M: Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 1989;6:67-75
15. Sorensen KE Celermajer DS, Spiegelhalter DJ: Non-invasive measurement of human endothelium dependent arterial responses: Accuracy and reproducibility. Br Heart J 1995;6:67-75
16. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH: The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340:1449-1454
17. Robinson K, Arheart K, Refsum H, Brattström L, Boers G, Ueland P, Rubba P, Palma-Reis R, Meleady R, Daly L, Witteman J, Graham I, for the European COMAC Group: Low circulating folate and vitamin B6 concentrations risk factor for stroke, peripheral vascular disease, and coronary artery disease. Circulation 1998;97:437-443
18. Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V: Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-1231
19. Kaptan K, Beyan C, Ural AU, Cetin T, Avcu F, Gulsen M, Finci R, Yalcin A: Helicobacter pylori - Is it a novel causative agent in vitamin B12 deficiency? Arch Intern Med 2000;160:1349-1353
20. Figueroa G, Acuña R, Troncoso M, Portell DP, Toledo MS, Valenzuela J: Helicobacter pylori infection in Chile. Clin Infect Dis 1997;25:96-102
21. Hanratty CG, McAuley DF, McGrath LT, Young IS. Johnston GD: Hyperhomocysteinaemia in young adults is not associated with impaired endothelial function. Clin Sci (Colch) 2001;100:67-72
22. Celermajer DS, Sorenson KE, Ryalls M, Robinson J, Thomas Q, Leonard JV, Deanfild JE: Impaired endothelial function occurs in the systemic arteries of children with homozygous homocysteinuria but not in their heterozygous parents. J Am Coll Cardiol 1993;22:854-858
23. Hanratry CG, McGrath LT, McAuley DF, Young IS, Johnston GD: The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85:326-330
24. Usui M, Matsuoka H, Miyazaki H, Ueda S, Imaizumi T: Endothelial dysfunction by acute hyperhomocysteinemia: Restoration by folic acid. Clin Sci 1999;96:235-239
25. Chao CL, Chien KL, Lee YT: Effect of short-term vitamin (folic acid, vitamin B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia. Am J Cardiol 1999;84:1359-1361
26. Woo KS, Chook P, Lolin YI, Sanderson JE, Metreweli C, Celermajer DS: Folic acid improves arterial endothelial function in adults with hyperhomocystinemia. J Am Coll Cardiol 1999;34:2002-2006
27. Chambers JC, Ueland PM, Obeid OA, Wrigley J, Refsum H, Kooner JS: Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000;102:2479-2483
28. Thambyajah J, Landray MJ, McGlynn FJ, Jones HJ, Wheeler DC, Townend JN: Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure? Circulation 2000;102:871-875
29. Lentz SR, Piegors DJ, Malinow MR, Heistad DD: Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys. Circulation 2001;1031:1006-1011
30. Harman D: Free radical theory of aging. Mutation Res 1992;275:257-266
31. Freyburger G, Labrouche S, Sassoust G, Rouanet F, Javorschi S, Parrot F: Mild hyperhomocysteinemia and hemostatic factors in patients with arterial vascular diseases. Thromb Haemost 1997;77:466-471
32. Lentz SR, Sadler JE: Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 1991;88:1906-1914