HIV production form purified monocytes isolated form antiretroviral-naïve and protease inhibitor-treated HIV-1-infected patients

HIV Clinical Trials

Volumn 3, Issue 6, 2002, Pages 469-474

  Kazanjian, Powel ^a   Adams, Donna ^b   Tate, Stacey ^b   Newman, Gale ^b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

HIV production; Macrophages; Protease inhibitor

Indexed keywords

ANTIRETROVIRUS AGENT; GAG PROTEIN; INDINAVIR; NELFINAVIR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

ADULT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; MACROPHAGE; MALE; MONOCYTE; PRIORITY JOURNAL; SUPERNATANT; VIREMIA; VIROLOGY; VIRUS ACTIVATION; VIRUS LOAD; VIRUS REPLICATION; BLOOD; CASE CONTROL STUDY; ISOLATION AND PURIFICATION; MIDDLE AGED; PHYSIOLOGY;

ADULT; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MALE; MIDDLE AGED; MONOCYTES; VIRAL LOAD;

EID: 0036827089     PISSN: 15284336     EISSN: None     Source Type: Journal    
DOI: 10.1310/EF26-V3PC-AG5X-FCF4     Document Type: Article

References (32)

1. Gendelman HE, Orenstein JM, Baca LM, et al. The macrophage in the persistence and pathogenesis of HIV infection. AIDS. 1989;3:475-495.
2. Lewin SR, Kirihara J, Sonza S, et al. HIV-1 DNA and mRNA concentrations are similar in peripheral blood monocytes and alveolar macrophages in HIV-1 infected individuals. AIDS. 1998;12:719-727.
3. Martin JC, Bandres JC. Cells of the monocyte-macrophage lineage and pathogenesis of HIV-1 infection. J Acquir Immune Defic Syndr. 1999;22:413-429.
4. Koup R. Host factors in HIV transmission and disease pathogenesis. In: Program and abstracts of the 4th Conference on Retroviruses and Opportunistic Infections; 1997; Washington, DC. Abstract S37.
5. Fauci A. From knowledge about the virus to better treatment; host factors in pathogenesis of HIV. Implications for therapy. In: Program and abstracts of the 12th World AIDS Conference; 1998; Geneva, Switzerland. Abstract 157.
6. Alkhatib G, Combardiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1alpha, and MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 1996;272:1955-1958.
7. Agrawal L, Vieth E, Alkhatib G. Functional isolation of a novel HIV co-receptor (CCRX): a potential receptor for the macrophage-derived chemokine. In: Program and abstracts of the 7th National Conference on Retroviruses and Opportunistic Infections; 2000; San Francisco, California. Abstract 418.
8. Speck RF, Gosling J, Atchison RE, et al. Regulation of cellular tropism and co-receptor utilization of HIV-1. In: Program and abstracts of the 4th Conference on Retroviruses and Opportunistic Infections; 1997; Washington, DC. Abstract SI737.
9. Collman RG, Liu OH, Doms RA, et al. HIV-1 gp 120 and chemokines elicit distinct patterns of ion channel activation via CCR5 and CXCR4 in macrophages. In: Program and abstracts of the 7th National Conference on Retroviruses and Opportunistic Infections; 2000; San Francisco, California. Abstract 410.
10. Ylisastigui L, Vizzovona J, Drakopoulou E, et al. Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages. AIDS. 1998;12:977-984.
11. Pomerantz RJ, de la Monte SM, Donegan SP, et al. Human immunodeficiency virus (HIV) infection of the uterine cervix. Ann Intern Med. 1988;108:321-327.
12. Koening S, Gendelman, HE, Orenstein JM, et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science. 1986;233:1089-1093.
13. Cao YZ, Dieterich D, Thomas PA, et al. Identification and quantitation of HIV-1 in the liver of patients with AIDS. AIDS. 1992;6:65-70.
14. Smith PD, Fox CH, Masur H, et al. Quantitative analysis of mononuclear cells expressing human immunodeficiency virus type 1 RNA in esophageal mucosa. J Exp Med. 1994;180:1541-1546.
15. Moreno P, Rebollo MJ, Pulido F, et al. Alveolar macrophages are not an important source of viral production in HIV-1 infected patients. AIDS. 1996;10:682-684.
16. McIlroy D, Autran B, Cheynier R, et al. Infection frequency of dendritic cells and CD4+ T lymphocytes in spleens of human immunodeficiency virus-positive patients. J Virol. 1995;69:4737-4745.
17. Perelson AS, Neumann AU, Markowitz M, et al. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science. 1996;271:1582-1586.
18. Quiros E, Garcia F, Maroto MC, et al. Human immunodeficiency virus type-1 can be detected in monocytes by polymerase chain reaction. J Med Microbiol. 1995;42:411-414.
19. Lambotte O, Taoufik Y, de Goer MG, et al. Detection of infectious HIV in monocyte derived macrophages from patients on prolonged highly active antiretroviral therapy. JAIDS. 2000;23:114-119.
20. Perno CF, Newcomb FM, Davis DA, et al. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J Infect Dis. 1998;178:413-422.
21. Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5:512-517.
22. Havlir DV, Richman DD. Viral dynamics of HIV: implications for drug development and therapeutic strategies. Ann Intern Med. 1996;12:984-994.
23. Mellors J. Viral determinants of HIV disease progression. In: Program and abstracts of the 4th Conference on Retroviruses and Opportunistic Infections; 1997; Washington, DC. Abstract S38.
24. Silicano R. Cure of HIV: myth or reality? In: Program and abstracts of the 12th World AIDS Conference; 1998; Geneva, Switzerland. Abstract 158.
25. Smith PD, Meng G, Shaw GM, et al. Infection of gastrointestinal tract macrophages by HIV-1. J Leukoc Biol. 1997;62:72-77.
26. Brichacek B, Swindells S, Janoff EN, et al. Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine. J Infect Dis. 1996;174:1191-1199.
27. Stanley SK, Ostrowski MA, Justement JS, et al. Effect of immunization with a common recall antigen on viral expression in patients with human immunodeficiency virus type 1. N Engl J Med. 1996;334:1222-1230.
28. Zhang Z, Schuler T, Zupancic M, et al. Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science. 1999;286:1353-1357.
29. Naif HM, Li S, Alali M, et al. CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infection. J Virol. 1998;72:830-836.
30. Wang J, Roderiquez G, Oravecz T, et al. Cytokine regulation of human immunodeficiency virus type 1 entry and replication in human monocytes/macrophages through modulation of CCR5 expression. J Virol. 1998;72:7642-7647.
31. Butler SL, Hansen MST, Bushman FD. A quantitative assay for HIV cDNA integration in vivo: factors modulating early infection. In: Programs and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections; February 4-8, 2001; Chicago, Illinois. Abstract 285.
32. Zhang H, Dornadula G, Beumont M, et al. Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy. N Engl J Med. 1998;339:1803-1809.