Recurrent miscarriage - A critical appraisal

Reproductive Medicine Review

Volumn 10, Issue 3, 2002, Pages 165-176

  Rai, R ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABORTION; ANTIPHOSPHOLIPID SYNDROME; CHROMOSOME REARRANGEMENT; DECIDUA; ENDOCRINE DISEASE; FERTILIZATION IN VITRO; HUMAN; IMMUNITY; OVARY POLYCYSTIC DISEASE; PREGNANCY; PRIORITY JOURNAL; RECURRENT ABORTION; REVIEW; SPONTANEOUS ABORTION; THROMBOPHILIA; X CHROMOSOME INACTIVATION;

EID: 0036826554     PISSN: 09622799     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0962279902000327     Document Type: Review

References (60)

1. Kline J. Conception to Birth - Epidemiology of Prenatal Development. Monographs in Epidemiology and Biostatistics. Oxford, Oxford University Press; 1989.
2. Semprini AE, Simoni G. Not so inefficient reproduction. Lancet 2000; 356: 257-258.
3. Warburton D, Fraser FC. Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit. Hum Genet 1964; 16: 1-25.
4. Stem JJ, Dorfmann AD, Gutiérrez-Najar AJ, Cerrillo M, Coulam CB. Frequency of abnormal karyotypes among abortuses from women with and without a history of recurrent spontaneous abortion. Fertil Steril 1996; 65: 250-253.
5. Ogasawara M, Aoki K, Okada S, Suzumori K. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 2000; 73: 300-304.
6. Carp H, Toder V, Aviram A, Daniely M, Mashiach S, Barkai G. Karyotype of the abortus in recurrent miscarriage. Fertil Steril 2001; 75: 678-682.
7. Stephenson MD, Awartani KA, Robinson WP. Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case-control study. Hum Reprod 2002; 17: 446-451.
8. Lomax B, Tang S, Separovic E, Phillips D, Hillard E, Thomson T et al. Comparative genomic hybridization in combination with flow cytometry improves results of cytogenetic analysis of spontaneous abortions. Am J Hum Genet 2000; 66: 1516-1521.
9. Stephenson MD, Awartani KA, Robinson WP. Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case-control study. Hum Reprod 2002; 17: 446-451.
10. Pellicer A, Rubio C, Vidal F, Minguez Y, Gimenez C, Egozcue J et al. In vitro fertilization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplantation embryos. Fertil Steril 1999; 71: 1033-1039.
11. Rubio C, Rodrigo L, Phelivan T, Simon C, Remohi JA, Pellicer A. Preimplantation genetic diagnosis in implantation failure and recurrent pregnancy loss. Hum Reprod 2002; 17(Abstract Book 1): 29.
12. Clifford K, Rai R, Watson H, Regan L. An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Hum Reprod 1994; 9: 1328-1332.
13. Munne S, Escudero T, Sandalinas M, Sable D, Cohen J. Gamete segregation in female carriers of Robertsonian translocations. Cytogenet Cell Genet 2000; 90: 303-308.
14. Honda H, Miharu N, Samura O, He H, Ohama K. Meiotic segregation analysis of a 14;21 Robertsonian translocation carrier by fluorescence in situ hybridization. Hum Genet 2000; 106: 188-193.
15. Sangha KK, Stephenson MD, Brown CJ, Robinson WP. Extremely skewed X-chromosome inactivation is increased in women with recurrent spontaneous abortion. Am J Hum Genet 1999;65:913-917.
16. Lanasa MC, Hogge WA, Kubik C, Blancato J, Hoffman EP. Highly skewed X-chromosome inactivation is associated with idiopathic recurrent spontaneous abortion. Am J Hum Genet 1999;65:252-254.
17. Mills JL, Simpson JL, Driscoll SG, Jovanovic-Peterson L, Van Allen M, Aarons JH et al. Incidence of spontaneous abortion among normal women and insulin-dependent diabetic women whose pregnancies were identified within 21 days of conception. N Engl J Med 1988; 319: 1617-1623.
18. Rushworth FH, Backos M, Rai R, Chilcott IT, Baxter N, Regan L. Prospective pregnancy outcome in untreated recurrent miscarriers with thyroid autoantibodies. Hum Reprod 2000; 15: 1637-1639.
19. Rai R, Backos M, Rushworth F, Regan L. Polycystic ovaries and recurrent miscarriage - a reappraisal. Hum Reprod 2000; 15: 612-615.
20. Regan L, Owen EJ, Jacobs HS. Hypersecretion of luteinising hormone, infertility, and miscarriage. Lancet 1990; 336: 1141-1144.
21. Balen AH, Tan SL, MacDougall J, Jacobs HS. Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum Reprod 1993; 8: 959-964.
22. Clifford K, Rai R, Watson H, Franks S, Regan L. Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial. Br Med J 1996; 312: 1508-1511.
23. Nardo LG, Rai R, Backos M, El Gaddal S, Regan L. High serum luteinizing hormone and testosterone concentrations do not predict pregnancy outcome in women with recurrent miscarriage. Fertil Steril 2002; 77: 348-352.
24. Dale PO, Tanbo T, Haug E, Abyholm T. The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome. Hum Reprod 1998; 13: 567-570.
25. Jakubowicz DJ, Iuorno MJ, Jakubowicz S, Roberts KA, Nestler JE. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87: 524-529.
26. Glueck CJ, Wang P, Kobayashi S, Phillips H, Sieve-Smith L. Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril 2002; 77: 520-525.
27. Rai RS, Regan L, Clifford K, Pickering W, Dave M, Mackie I et al. Antiphospholipid antibodies and Beta2-glycoprotein-I in 500 women with recurrent miscarriage: results of a comprehensive screening approach. Hum Reprod 1995; 10: 2001-2005.
28. Rai RS, Clifford K, Cohen H, Regan L. High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Hum Reprod 1995; 10: 3301-3304.
29. Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). Br Med J 1997; 314: 253-257.
30. Farquharson RG, Quenby S, Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol 2002; 100: 408-413.
31. De Wolf F, Carreras LO, Moerman P, Vermylen J, Van Assche A, Renaer M. Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant. Am J Obstet Gynecol 1982; 142: 829-834.
32. Empson M, Lassere M, Craig JC, Scott JR. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol 2002; 99: 135-144.
33. Mak IY, Brosens JJ, Christian M, Hills FA, Chamley L, Regan L et al. Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro. J Clin Endocrinol Metab 2002; 87: 2581-2588.
34. Katsuragawa H, Kanzaki H, Inoue T, Hirano T, Mori T, Rote NS. Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion. Biol Reprod 1997; 56: 50-58.
35. Di Simone N, Castellani R, Caliandro D, Caruso A. Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules. Fertil Steril 2002; 77: 805-811.
36. Sebire NJ, Fox H, Backos M, Rai R, Paterson C, Regan L. Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. Hum Reprod 2002; 17: 1067-1071.
37. Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haemost 1984; 52: 176-182.
38. Rushton DI. Placental pathology in spontaneous miscarriage. In Beard RW, Sharp F (eds) Early Pregnancy Loss: Mechanisms and Treatment. London: RCOG, 1988: pp. 149-158.
39. Sanson B-J, Freiderich PW, Simioni P, Zanardi S, Huisman MV, Girolami A, Cate J-W, Prins MH. The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women. Thromb Haemost 1996; 75: 387-388.
40. Rai R, Shlebak A, Cohen H, Backos M, Holmes Z, Marriott K et al. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod 2001; 16: 961-965.
41. Brenner B, Sarig G, Weiner Z, Younis J, Blumenfeld Z, Lanir N. Thrombophilic polymorphisms are common in women with fetal loss without apparent cause. Thromb Haemost 1999; 82: 6-9.
42. Gris JC, Ripart NS, Maugard C, Tailland ML, Brun S, Courtieu C et al. Respective evaluation of the prevalence of haemostasis abnormalities in unexplained primary early recurrent miscarriages. The Nimes Obstetricians and Haematologists (NOHA) Study. Thromb Haemost 1997; 77: 1096-1103.
43. Preston FE, Rosendaal FR, Walker ID, Briet E, Berntorp E. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-916.
44. Rai R, Backos M, Elgaddal S, Shlebak A, Regan L. Factor V Leiden and recurrent miscarriage-prospective outcome of untreated pregnancies. Hum Reprod 2002; 17: 442-445.
45. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999; 340: 9-13.
46. Salooja N, Perry DJ. Thrombelastography. Blood Coagul Fibrinolysis 2001; 12: 327-337.
47. Loke YW, King A. Immunological aspects of human implantation. J Reprod Fertil (Suppl) 2000; 55: 83-90.
48. Quenby S, Bates M, Doig T, Brewster J, Lewis-Jones DI, Johnson PM et al. Pre-implantation endometrial leukocytes in women with recurrent miscarriage. Hum Reprod 1999; 14: 2386-2391.
49. Clifford K, Flanagan AM, Regan L. Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study. Hum Reprod 1999; 14: 2727-2730.
50. Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D, Beer AE. Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol. 1995; 34: 93-99.
51. Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 2000; 15: 713-718.
52. Takakuwa K, Arakawa M, Honda K, Imai T, Tamura M, Yasuda M et al. Alterations of lymphocyte subsets in patients with recurrent fetal wastage positive for antiphospholipid antibodies treated with Chinese herbal medicine. J Perinat Med 1997; 25: 385-387.
53. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14: 353-356.
54. von Wolff M, Thaler CJ, Strowitzki T, Broome J, Stolz W, Tabibzadeh S. Regulated expression of cytokines in human endometrium throughout the menstrual cycle: dysregulation in habitual abortion. Mol Hum Reprod 2000; 6: 627-634.
55. Lim KJ, Odukoya OA, Ajjan RA, Li TC, Weetman AP, Cooke ID. The role of T-helper cytokines in human reproduction. Fertil Steril 2000; 73: 136-142.
56. Bates MD, Quenby S, Takakuwa K, Johnson PM, Vince GS. Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss? Hum Reprod 2002; 17: 2439-2444.
57. Clifford K, Rai R, Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod 1997; 12: 387-389.
58. Rai R, Backos M, Baxter N, Chilcott I, Regan L. Recurrent miscarriage - an aspirin a day? Hum Reprod 2000; 15: 2220-2223.
59. Goldstein P, Berrier J, Rosen S, Sacks HS, Chalmers TC. A meta-analysis of randomized control trials of progestational agents in pregnancy. Br J Obstet Gynaecol 1989; 96: 265-274.
60. Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A et al. Global gene profiling in human endometrium during the window of implantation. Endocrinology 2002; 143: 2119-2138.