Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine

Molecular Pharmacology

Volumn 52, Issue 3, 1997, Pages 430-436

  Kim, Seong Hun ^a   Kim, Young Kyung ^b   Jeong, Sung Jin ^a   Haass, Christian ^c   Kim, Young Moon ^b   Suh, Yoo Hun ^a  

^a Seoul National University   (South Korea)

^b Inje University   (South Korea)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CALCIUM CHELATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; EGTAZIC ACID; MECAMYLAMINE; NICOTINE; NICOTINIC RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN PROTECTION; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DOSE RESPONSE; NERVE CELL NECROSIS; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN SECRETION; RAT; SENILE PLAQUE;

EID: 0030880424     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.3.430     Document Type: Article

References (40)

1. Selkoe, D. J. Alzheimer's disease: a central role for amyloid. J. Neuropathol. Exp. Neurol. 53:438-447 (1994).
2. Checler, F. Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65:1431-1444 (1995).
3. Mattson, M. P., B. Cheng, A. R. Culwell, F. S. Esch, I. Lieberburg, and R. E. Rydel. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10: 243-254 (1993).
4. Nitsch, R. M., B. E. Slack, R. J. Wurtman, and J. H. Growdon. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science (Washington D. C.) 258:304-307 (1992).
5. Buxbaum, J. D., M. Oishi, H. I. Chen, R. Pinkas-Kramarski, E. A. Jaffe, S. E. Gandy, and P. Greengard. Cholinergic agonists and interleukin-1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA 89:10075-10078 (1992).
6. Nitsch, R. M., B. E. Slack, S. A. Farber, P. R. Borghesani, J. G. Schulz, C. Kim, C. C. Felder, J. H. Growdon, and R. J. Wurtman. Receptor-coupled amyloid precursor protein processing. Ann. N. Y. Acad. Sci. 881:122-127 (1994).
7. Davis-Salinas, J., S. M. Saporito-Irwin, F. M. Donovan, D. D. Cunningham, and W. E. VanNostrand. Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid β-protein precursor. J. Biol. Chem. 269:22623-22627 (1994).
8. Lee, R. K. K., R. J. Wurtman, A. J. Cox, and R. M. Nitsch. Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc. Natl. Acad. Sci. USA 92:8083-8087 (1995).
9. 2c receptors stimulate amyloid precursor protein ectodomain secretion. J. Biol. Chem. 271:4188-4194 (1996).
10. Caporaso, G. L., S. E. Gandy, J. D. Buxbaum, T. V. Ramabbadran, and P. Greengard. Protein phosphorylation regulates secretion of Alzheimer's β/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. USA 89:3055-3059 (1992).
11. Hung, A. Y., C. Haass, R. M. Nitsch, W. Q. Qiu, M. Citron, R. J. Wurtman, J. H. Growdon, and D. J. Selkoe. Activation of protein kinase C inhibits cellular production of the amyloid β protein. J. Biol. Chem. 268:22959-22962 (1993).
12. Xu, H., P. Greengard, and S. Gandy. Regulated formation of Golgi secretory vesicles containing Alzheimer β-amyloid precursor protein. J. Biol. Chem. 270:23243-23245 (1995).
13. Buxbaum, J. D., A. A. Ruefli, C. A. Parker, A. M. Cypess, and P. Greengard. Calcium regulates processing of the Alzheimer's amyloid protein precursor in a protein kinase C-independent manner. Proc. Natl. Acad. Sci. USA 91:4489-4493 (1994).
14. Loefler, J., and G. Huber. Modulation of β-amyloid precursor protein secretion in differentiated and nondifferentiated cells. Biochem. Biophys. Res. Commun. 195:97-103 (1993).
15. McGehee, D. S., and L. W. Role. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu. Rev. Physiol. 57:521-546 (1995).
16. Levin, E. D. Nicotinic systems in cognitive function. Psychopharmacology 108:417-431 (1992).
17. Kellar, K. J., and S. Wonnacott. Nicotinic cholinergic receptors in Alzheimer's disease, in Nicotine Psychopharmacology: Molecular, Cellular and Behavioral Aspects (S. Wonnacott, M. A. H. Russel and I. P. Stolerman, eds.). Oxford University Press, Oxford, 341-373 (1990).
18. Bierer, L. M., V. Haroutunian, S. Gabriel, P. J. Knott, L. S. Carlin, D. P. Purohit, D. P. Perl, J. S. Philipknanof, and K. L. Davis. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J. Neurochem. 64:749-760 (1995).
19. Smith, C. J., and E. Giacobini. Nicotine, Parkinson's, and Alzheimer's disease. Rev. Neurosci. 3:25-42 (1992).
20. Newhouse, P. A., T. Sunderland, P. N. Tariot, C. L. Blumhardt, H. Weingartner, A. Mellow, and D. L. Murphey. Intravenous nicotine in Alzheimer's disease: a pilot study. Psychopharmacology 95:171-175 (1988).
21. Jones, G. M. M., B. J., R. Levy, D. M. Warburton, and J. A. Gray. Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology 108:485-494 (1992).
22. Selkoe, D. J., M. B. Podlisny, C. L. Joachim, E. A. Vickers, G. Lee, L. C. Fritz, and T. Oltersdorf. Beta-amyloid precursor protein of Alzheimer disease occurs as 110-to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc. Natl. Acad. Sci. USA 85:7341-7345 (1988).
23. Sisodia, S. S., E. H. Koo, P. N. Hoffman, G. Perry, and D. L. Price. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13:3136-3142 (1993).
24. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159 (1987).
25. Haass, C., M. G. Schlossmacher, A. Y. Hung, C. Vigo Pelfrey, A. Mellon, B. L. Ostaszewski, I. Lieberburg, E. H. Koo, D. Schenk, D. B. Teplow, and D. J. Selkoe. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature (Lond.) 359:322-325 (1992).
26. Citron, M., T. Oltersdorf, C. Haass, L. McConlogue, A. Y. Hung, P. Seubert, C. Vigo-Pelfrey, I. Lieberburg, and D. J. Selkoe. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature (Lond.) 360:672-674 (1992).
27. Sands, S. B., and M. E. Barish. Neuronal nicotinic acetylcholine receptor currents in phaeochromocytoma (PC12) cells: dual mechanisms of rectification. J. Physiol. 447:467-487 (1992).
28. Henderson, L. P., M. J. Gdovin, C. Liu, P. D. Gardner, and R. A. Maue. Nerve growth factor increases nicotinic Ach receptor gene expression and current density in wild-type and protein kinase A-deficient PC12 cells. J. Neurosci. 14:1153-1163 (1994).
29. Ripellino, J. A., D. Vassilacopoulou, and N. K. Robakis. Solubilization of full-length amyloid precursor proteins from PC12 cell membranes. J. Neurosci. Res. 39:211-218 (1994).
30. Efthimiopoulos, S., D. Vassilacopoulou, J. A. Ripellino, N. Tezapsidis, and N. K. Robakis. Cholinergic agonists stimulate secretion of soluble full length amyloid precursor protein in neuroendocrine cells. Proc. Natl. Acad. Sci. USA 93:8046-8050 (1996).
31. Sambamurti, K., J. Shioi, J. P. Anderson, M. A. Papolla, and N. Robakis. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J. Neurosci. Res. 33:319-329 (1992).
32. Vernino, S., M. Amador, C. W. Leutje, J. Patrick, and J. A. Dani. Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8:127-134 (1992).
33. Nitsch, R. M., S. A. Farber, J. H. Growdon, and R. J. Wurtman. Release of amyloid β-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proc. Natl. Acad. Sci. USA 90:5191-5193 (1993).
34. Querfurth, H. W., and D. J. Selkoe. Calcium ionophore increases amyloid β peptide production by cultured cells. Biochemistry 33:4550-4561 (1994).
35. Allsop, D., T. Yamamoto, F. Kametani, N. Miyazaki, and T. Ishii. Alzheimer amyloid β/A4 peptide binding sites and a possible "APP-secretase" activity associated with rat brain cortical membranes. Brain Res. 551:1-9 (1991).
36. Dyrks, T., U. Moenning, K. Beyreuther, and J. Turner. Amyloid precursor protein secretion and βA4 amyloid generation are not mutually exclusive. FEBS Lett. 349:210-214 (1994).
37. Akaike, A., Y. Tamura, T. Yokota, S. Shimohama, and J. Kimura. Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Res. 644:181-187 (1994).
38. Yamashito, H., and S. Nakamura. Nicotine rescues PC12 cells from death induced by nerve growth factor deprivation. Neurosci. Lett. 213:145-147 (1996).
39. Janson, A. M., K. Fuxe, L. F. Agnati, A. Jansson, B. Bjelke, E. Sundstrom, K. Anderson, A. Harfstrand, M. Goldstein, and C. Owman. Protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat. Prog. Brain Res. 79:257-265 (1989).
40. McGehee, D. S., M. J. S. Heath, S. Gelber, P. Devay, and L. W. Role. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science (Washington D. C.) 269:1692-1696 (1995).