Recombinant nematode anticoagulant protein c2, a novel inhibitor of tissue factor-factor VIIa activity, abrogates endotoxin-induced coagulation in chimpanzees

Thrombosis and Haemostasis

Volumn 88, Issue 4, 2002, Pages 627-631

  Moons, Arno H M ^a   Peters, Ron J G ^a   Ten Cate, Hugo ^a   Bauer, Kenneth A ^a   Vlasuk, George P ^a   Büller, Harry R ^a   Levi, Marcel ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Chimpanzees; Endotoxin; rNAPc2; Thrombin generation; Tissue factor factor VIIa

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7A INHIBITOR; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING INHIBITOR; ESCHERICHIA COLI ENDOTOXIN; PLACEBO; PROTHROMBIN; PROTHROMBIN ACTIVATION FRAGMENT 1 + 2; RECOMBINANT NEMATODE ANTICOAGULANT PROTEIN C2; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; TISSUE FACTOR PATHWAY INHIBITOR; UNCLASSIFIED DRUG; ANTI COAGULANT PROTEIN C2, ANCYLOSTOMA CANINUM; ANTI-COAGULANT PROTEIN C2, ANCYLOSTOMA CANINUM; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 7A; ENDOTOXIN; HELMINTH PROTEIN; RECOMBINANT PROTEIN; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CHIMPANZEE; CLONE; CONTROLLED STUDY; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENDOTOXEMIA; FIBRINOLYSIS; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE SEPSIS; METABOLIC ACTIVATION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG ANTAGONISM; METABOLISM; PAN TROGLODYTES; PROTEIN BINDING;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; DISEASE MODELS, ANIMAL; DISSEMINATED INTRAVASCULAR COAGULATION; ENDOTOXEMIA; ENDOTOXINS; FACTOR VIIA; HELMINTH PROTEINS; PAN TROGLODYTES; PROTEIN BINDING; RECOMBINANT PROTEINS; THROMBIN; THROMBOPLASTIN;

EID: 0036796103     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613266     Document Type: Article

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