Attenuation of tissue thrombosis and hemorrhage by ala-TFPI does not account for its protection against E. coli: A comparative study of treated and untreated non-surviving baboons challenged with LD100 E. coli

Thrombosis and Haemostasis

Volumn 79, Issue 5, 1998, Pages 1048-1053

  Randolph, M M ^a   White, G L ^a   Kosanke, S D ^a   Bild, G ^b   Carr, C ^b   Galluppi, G ^b   Hinshaw, L B ^c   Taylor Jr , F B ^c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; FIBRIN; TISSUE FACTOR PATHWAY INHIBITOR;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BABOON; BLEEDING; CHEMICAL PARAMETERS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; KIDNEY PARENCHYMA; LUNG ALVEOLUS; LUNG EDEMA; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SEPSIS; TARGET ORGAN; THROMBOSIS;

EID: 0031977806     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615118     Document Type: Article

References (16)

1. Rapaport SI. The extrinsic pathway inhibitor: a regulator of tissue factor-dependent blood coagulation. Thromb Haemost 1991; 66 (1): 6-5.
2. Nemerson Y. The reaction between bovine brain tissue factor and factors VII and X. Biochem 1966; 5: 601-8.
3. Osterud B, Rapaport SI. Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiation blood coagulation. Proc Nat Acad Sci USA 1977; 74: 5260-4.
4. Drake TA, Morrissey JH, Edgington T. Selective cellular expression of tissue factor in human tissues: Implications for disorders of hemostasis and thrombosis. Amer J Pathol 1989; 1087-97.
5. Risberg B, Adreasson S, Eriksson E. Disseminated intravascular coagulation. Acta Anaesthesiol Scand 1991; 35: 60-71.
6. Sandset M, Warn-Cramer BJ, Rao Vijaya M, Maki SL, Rapaport SI. Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiological role of EPI as a natural anticoagulant. Proc Nat Acad Sci USA 1991; 88: 708-12.
7. Creasey AA, Chang ACK, Feigen L, Wun TC, Taylor FB, Hinshaw LB. Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock. Journal of Clin Invest 1993; 91: 2850-60.
8. Can C, Bild GS, Chang ACK, Peer GT, Palmier MO, Frazier RB, Gustafson ME, Wun PC, Creasey AA, Hinshaw LB, Taylor FB, Jr, Galluppi GR. Recombinant E. coli-derived tissue factor pathway inhibitor reduces coagulopathic and lethal effects in the baboon gram negative model of septic shock. Circ Shock 1995; 44: 126-37.
9. Hinshaw LB, Brackett DJ, Archer LT, Beller BK, Wilson MF. Detection of the hyperdynamic state of sepsis in the baboon during lethal E. coli infusion. J Trauma 1982; 23: 361-5.
10. Hougie C. Methods for estimating fibrinogen concentration - thrombin time test. In: Hematology. WJ Williams, E Beutler, AJ Erslev, MA Lichtman, eds. McGraw-Hill, New York 1983, p 1667.
11. Wellcome Research Laboratories. Fibrinogen Degradation Products: Thrombo-Wellcotest (Rapid Latex Kit), Purley, Surrey, UK, Southern Press, 1984.
12. Jaffe M. Über den Niederschlag welchen Pikrinsäure in normalem Harn erzeugt und über eine neue Reaktion des Kreatinins. Hoppe Seylers Zeitschrift Physikalische Chemie, 1986; 10: 391.
13. 100 E. coli sepsis and in the early diagnosis of DIC in the baboon. In. DIC: Pathogenesis, Diagnosis and Therapy of Disseminated Intravascular Fibrin Formation, G. Muller-Berghaus, ed. Elsevier Science Publishers, 1993; pp 19-32.
14. 2+ signals in J82 cells, transfected COS-1 cells, Madin-Darby canine kidney cells and in human endothelial cells induced to synthesize tissue factor. J Biol Chem 1995; 270 (9): 4650-60.
15. 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active. J. Biol Chem 1996; 271: 29034.
16. Taylor FB, Chang AK, Mather T, Blick KE, Catlett R, Lockhart MS, Esmon CT. DEGR-factor Xa blocks disseminated intravascular coagulation initiated by E. coli without preventing shock or organ damage, Blood 1991; 78: 364-71.