Total synthesis of (+)-pumiliotoxin 251D

European Journal of Organic Chemistry

Volumn , Issue 19, 2002, Pages 3315-3325

  Sudau, Alexander ^a   Münch, Winfried ^a   Bats, Jan W ^b   Nubbemeyer, Udo ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Aldol reactions; Alkaloids; Lactams; Olefinations; Total synthesis

Indexed keywords

ALKENE; AMIDE; INDOLIZIDINE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PUMILIOTOXIN;

ARTICLE; POLYMERIZATION; REDUCTION; STEREOCHEMISTRY; SYNTHESIS; X RAY ANALYSIS;

EID: 0036795058     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0690(200210)2002:19<3315::AID-EJOC3315>3.0.CO;2-2     Document Type: Article

References (60)

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56. 1 (Figure 2).
57. K. Ando, J. Org. Chem. 1999, 64, 6815-6821.
58. 1H-HMQC, and H,H-COSY spectra.
59. 3, no grainy suspension but a sticky precipitate was formed (no stirring possible), the reduction failed.
60. The HPLC behavior of PTX 251 D 28 strongly depends on the injected concentration, the product was purified considering its tendency of a decreasing retention time when the column was overloaded.