Tumour morphology - Interplay between chromosome aberrations and founder cell differentiation

Histology and Histopathology

Volumn 17, Issue 4, 2002, Pages 1207-1212

  Gisselsson, David ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chromosome instability; Differentiation; Morphology; Stem cell; Telomere

Indexed keywords

TELOMERASE; TRANSCRIPTION FACTOR;

BLOOD DISEASE; CELL CLONING; CELL DIFFERENTIATION; CELL DIVISION; CELL HETEROGENEITY; CELL LINE; CELL LINEAGE; CELL POPULATION; CELL TRANSFORMATION; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME MUTATION; CYTOGENETICS; ENZYME ACTIVITY; GENE EXPRESSION; GENE STRUCTURE; GENE TRANSLOCATION; GENOME; HUMAN; MALIGNANT TRANSFORMATION; MITOSIS; MORPHOLOGY; MUTATION; NEOPLASM; ONCOGENE; PROTEIN EXPRESSION; REVIEW; SENESCENCE; SOLID TUMOR; STEM CELL; TUMOR; TUMOR CELL; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL DIFFERENTIATION; CELL NUCLEUS; CHROMOSOME ABERRATIONS; CYTOGENETICS; EVOLUTION; HUMANS; MUTATION; NEOPLASMS;

EID: 0036790748     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (35)

1. Artandi S.E, Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L. and DePinho R.A. (2000). Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406, 641-645.
2. Ashar H.R., Fejzo M.S., Tkachenko A., Zhou X., Fletcher J.A., Weremowicz S., Morton C.C. and Chada K. (1995). Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82, 57-65.
3. Biernaux C., Sels A., Huez G. and Stryckmans P. (1996). Very low level of major BCR-ABL expression in blood of some healthy individuals. Bone Marrow Transplant 17, 45-47.
4. Boukamp P. (1995). Transdifferentiation induced by gene transfer. Semin Cell Biol 6, 157-163.
5. Cleary M..L. (1991) Oncogenic conversion of transcription factors by chromosomal translocations. Cell 66, 619-622.
6. Cohen-Jonathan E., Bernhard E..J. and McKenna W.G. (1999). How does radiation kill cells. Curr. Opin. Chem Biol. 3, 77-83.
7. Crozat A., Åman P., Mandahl N. and Ron D. (1993). Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363, 640-644.
8. Debiec-Rychter M., Van Valckenborgh I., Van den Broeck C., Hagemeijer A., Van de Ven W.J., Kas K., Van Damme B. and Voz M.L. (2001). Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. Lab. Invest. 81, 1289-1297.
9. Enzinger F.M. and Weiss S.W. (1994). Soft tissue tumors. 3 edn. Mosby-Year Book, Inc. St. Louis.
10. Gisselsson D., Pettersson L., Höglund M., Heidenblad M., Gorunova L., Wiegant J., Mertens F., Dal Cin P., Mitelman F. and Mandahl N. (2000). Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity. Proc. Natl. Acad. Sci. USA 97, 5357-5362
11. Gisselsson D., Jonson T., Petersén Å., Strömbeck B., Dal Cin P., Höglund M., Mitelman F, Mertens F. and Mandahl M. (2001a). Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumours. Proc. Natl. Acad. Sci. USA, 98, 12683-12688.
12. Gisselsson D., Björk J., Höglund M., Mertens F., Dal Cin P., Åkerman M. and Mandahl N. (2001b). Abnormal nuclear shape in solid tumors reflects mitotic instability. Am. J. Pathol. 158, 199-206.
13. Gorunova L., Höglund M., Andrén-Sandberg A., Dawiskiba S., Jin Y., Mitelman F. and Johansson B. (1998). Cytogenetic analysis of pancreatic carcinomas: intratumor heterogeneity and nonrandom pattern of chromosome aberrations. Genes Chromosomes Cancer 23, 81-99
14. Grignani F., Ferrucci P.F., Testa U., Talamo G., Fagioli M., Alcalay M., Mencarelli A., Peschle C., Nicoletti I. and Pelicci P.G. (1993). The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74, 423-431.
15. Hatano M., Roberts C.W., Minden M., Crist W.M. and Korsmeyer S.J. (1991). Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science 253, 79-82.
16. Heim S. and Mitelman F. (1995). Cancer Cytogenetics. Wiley-Liss. New York.
17. Hibbard M.K., Kozakewich H.P., Dal Cin P., Sciot R., Tan X., Xiao S. and Fletcher J.A. (2000). PLAG1 fusion oncogenes in lipoblastoma. Cancer Res. 4869-4672.
18. Hiom K., Melek M. and Gellert M. (1998). DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 94, 463-470.
19. Jin Y., Höglund M., Jin C., Martins C., Wennerberg J., Åkervall J., Mandahl N., Mitelman F. and Mertens F. (1998). FISH characterization of head and neck carcinomas reveals that amplification of band 11q13 is associated with deletion of distal 11q. Genes Chromosomes Cancer 22, 312-320.
20. Kas K., Voz M.L., Roijer E., Åstrom A.K., Meyen E., Stenman G. and Van de Ven W.J. (1997). Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat. Genet. 15, 170-174.
21. Klein G. and Klein E. (1986). Conditioned tumorigenicity of activated oncogenes. Cancer Res. 46, 3211-3224.
22. Kolquist K.A., Ellisen L.W., Counter C.M., Meyerson M., Tan L.K., Weinberg R.A., Haber D.A. and Gerald W.L. (1998). Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat. Genet. 19, 182-186.
23. Kuppers R. and Dalla-Favera R. (2001). Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580-5594.
24. Lleonart M.E., Martin-Duque P., Sanchez-Prieto R., Moreno A. and Ramon y Cajal S. (2000). Tumor heterogeneity: morphological, molecular and clinical implications. Histol. Histopathol. 17, 881-898.
25. Mandahl N. (1996). Cytogenetics and molecular genetics of bone and soft tissue tumors. Adv. Cancer Res. 69, 63-99
26. McClintock B. (1938). The production of homozygous deficient tissues with mutant characteristics by means of the aberrant behavior of ring-shaped chromosomes. Genetics 23, 215-376.
27. McClintock B. (1940). The stability of broken ends of chromosomes in Zea mays. Genetics 26, 234-282.
28. Miura I., Takahashi N., Kobayashi Y., Saito K. and Miura A.B. (2000). Molecular cytogenetics of stem cells: target cells of chromosome aberrations as revealed by the application of fluorescence in situ hybridization to fluorescence-activated cell sorting. Int. J. Hematol. 72, 310-317.
29. Olsson I., Bergh G., Ehinger M. and Gullberg U. (1996). Cell differentiation in acute myeloid leukemia. Eur. J. Haematol. 57, 1-16.
30. Pejovic T., Heim S., Mandahl N., Baldetorp B., Elmfors B., Flodérus U.M., Furgyik S., Helm G., Himmelmann A., Willén H. and Mitelman F. (1992). Chromosome aberrations in 35 primary ovarian carcinomas. Genes Chromosomes Cancer 4, 58-68.
31. Rowley J.D., Golomb H.M. and Dougherty C. (1977). 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia. Lancet 1, 549-550.
32. Rudolph K.L., Millard M., Bosenberg M.W. and DePinho R.A. (2001). Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28, 155-159.
33. Saunders W.S., Shuster M., Huang X., Gharaibeh B., Enyenihi A.H., Petersen I. and Gollin S.M. (2000). Chromosomal instability and cytoskeletal defects in oral cancer cells. Proc. Natl. Acad. Sci. USA 97, 303-308.
34. Schoenmakers E.F.P.M., Wanschura S., Mols R., Bullerdiek J., Van den Berghe H. and Van de Ven W.J.M. (1995). Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat. Genet. 10, 436-444.
35. Shteper P.J. and Ben-Yehuda D. (2001). Molecular evolution of chronic myeloid leukaemia. Semin. Cancer Biol. 11, 313-323.