Neutrophil response to Neisseria meningitidis: Inhibition of adhesion molecule expression and phagocytosis by recombinant bactericidal/permeability-increasing protein (rBPI21)

Journal of Infectious Diseases

Volumn 179, Issue 5, 1999, Pages 1288-1292

  Heyderman, R S ^a,b,c,d   Ison, C A ^a,b,c   Peakman, M ^a,b,c   Levin, M ^a,b,c   Klein, N J ^a,b,c  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d Dept Anat Sch Med Sci U   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERICIDAL PERMEABILITY INCREASING PROTEIN; CD11B ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; L SELECTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; HUMAN; LEUKOCYTE ACTIVATION; MENINGOCOCCEMIA; NEISSERIA MENINGITIDIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTYPE;

ADULT; BACTEREMIA; CELL ADHESION MOLECULES; HUMANS; L-SELECTIN; MACROPHAGE-1 ANTIGEN; MEMBRANE PROTEINS; MENINGOCOCCAL INFECTIONS; NEISSERIA MENINGITIDIS; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHAGOCYTOSIS;

EID: 0032969253     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314706     Document Type: Article

References (18)

1. 1. Jones DM. Epidemiology of meningococcal disease in Europe and the USA. In: Cartwright K, ed. Meningococcal disease. Chichester, UK: John Wiley & Sons, 1995:71-114.
2. 2. Brandtzaeg P. Pathogenesis of meningococcal disease. In: Cartwright K, ed. Meningococcal disease. Chichester, UK: John Wiley & Sons, 1995:71-114.
3. 3. McIntyre TM, Modur V, Prescott SM, Zimmerman GA. Molecular mechanisms of early inflammation. Thromb Haemost 1997;78:302-5.
4. 4. McNeil G, Virji M. Phenotypic variants of meningococci and their potential in phagocytic interactions: the influence of opacity proteins, pili, PilC and surface sialic acids. Microb Pathog 1997;22:295-304.
5. 5. Ison CA, Heyderman RS, Klein NJ, Peakman M, Levin M. Whole blood model of meningococcal bacteremia - a method for exploring host:bacterial interactions. Microb Pathog 1995;18:97-107.
6. 6. Klein NJ, Ison CA, Peakman M, et al. The influence of capsulation and lipooligosaccharide structure on neutrophil adhesion molecule expression and endothelial injury by Neisseria meningitidis. J Infect Dis 1996;173: 172-9.
7. 7. Gedde-Dahl TW, Bjark P, Høiby EA, Høst JH, Brunn JN. Severity of meningococcal disease: assessment by factors and scores and implications for patient management. Rev Infect Dis 1990;12:973-91.
8. 8. Sotto MN, Langer B, Hoshino-Shimizu S, de Brito T. Pathogenesis of cutaneous lesions in acute meningococcemia in humans: light, immunofluorescent, and electron microscopic studies of skin biopsy specimens. J Infect Dis 1976;133:506-14.
9. 9. Horwitz AH, Leigh SD, Abrahamson S, et al. Expression and characterisation of cyteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein. Protein Expr Purif 1996;8:28-40.
10. 10. Sjursen H, Bjerknes R, Halstensen A, Naess A, Sornes S, Solberg CO. Flow cytometric assay for the measurement of serum opsonins to Neisseria meningitidis serogroup B, serotype 15. J Immunol Methods 1989;116: 235-43.
11. 11. Guttormsen HK, Bjerknes R, Halstensen A, Naess A, Høiby A, Solberg CO. Cross-reacting serum opsonins to meningococci after vaccination. J Infect Dis 1993;167:1314-9.
12. 12. Westlin WF, Gimbrone MA. Neutrophil-mediated damage to human vascular endothelium: role of cytokine activation. Am J Pathol 1993;142:117-28.
13. 13. Prins JM, Speelman P, Kuijper EJ, Dankert J, Van Deventer SJH. No increase in endotoxin release during antibiotic killing of meningococci. J Antimicrob Chemother 1997;39:13-18.
14. 14. Heyderman RS, Klein NJ, Ison CA, et al. The induction of human endothelial tissue factor expression by Neisseria meningitidis. Microb Pathog 1997; 22:265-74.
15. 15. Ross SC, Rosenthal PJ, Berberich HM, Densen P. Killing of Neisseria meningitidis by human neutrophils: implications for normal and complement-deficient individuals. J Infect Dis 1987;155:1266-75.
16. 16. Delvig AA, Michaelsen TE, Aase A, Høiby EA, Rosenqvist E. Vaccine-induced IgG antibodies to the linear epitope on the PorB outer membrane protein promote opsonophagocytosis of Neisseria meningitidis by human neutrophils. Clin Immunol Immunopathol 1997;84:27-35.
17. 17. DeLeo FR, Renee J, McCormick S, et al. Neutrophils exposed to bacterial lipopolysaccharide upregulate NAPDH oxidase assembly. J Clin Invest 1998;101:455-63.
18. 18. Giroir BP, Quint PA, Barton P, et al. Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis. Lancet 1997;350: 1439-43.