-
1
-
-
0021782007
-
Trapidil derivatives as potent inhibitors of cyclic AMP phosphodiesterase from heart and coronary arteries
-
Bartel S, Tenor H, and Krause EG (1985) Trapidil derivatives as potent inhibitors of cyclic AMP phosphodiesterase from heart and coronary arteries. Biomed Biochim Acta 44:K31-K35.
-
(1985)
Biomed Biochim Acta
, vol.44
-
-
Bartel, S.1
Tenor, H.2
Krause, E.G.3
-
2
-
-
0017184389
-
A rapid and sensitive method for the quantification of microgram quantities of protein using the principle of protein-dye binding
-
Bradford M (1976) A rapid and sensitive method for the quantification of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72:248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.1
-
3
-
-
0028057469
-
Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells
-
Carroll MP and May WS (1994) Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. J Biol Chem 269:1249-1256.
-
(1994)
J Biol Chem
, vol.269
, pp. 1249-1256
-
-
Carroll, M.P.1
May, W.S.2
-
4
-
-
0002782772
-
Trapidil prevents rat vascular smooth muscle cell proliferation in vitro and in vivo
-
Cercek B, Ebrahimi R, Dimayuga P, Khorsandi M, and Forrester JS (1991) Trapidil prevents rat vascular smooth muscle cell proliferation in vitro and in vivo. J Am Coll Cardiol 17:72A.
-
(1991)
J Am Coll Cardiol
, vol.17
-
-
Cercek, B.1
Ebrahimi, R.2
Dimayuga, P.3
Khorsandi, M.4
Forrester, J.S.5
-
5
-
-
0028589148
-
Platelet-derived growth factor receptor signals
-
Claesson-Welsh L (1994) Platelet-derived growth factor receptor signals. J Biol Chem 269:32023-32026.
-
(1994)
J Biol Chem
, vol.269
, pp. 32023-32026
-
-
Claesson-Welsh, L.1
-
6
-
-
0027716596
-
Inhibition by cAMP of Ras-dependent activation of Raf
-
Cook SJ and McCormick FM (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science (Washington DC) 262:1069-1072.
-
(1993)
Science (Washington DC)
, vol.262
, pp. 1069-1072
-
-
Cook, S.J.1
McCormick, F.M.2
-
7
-
-
0027165150
-
The mitogen-activated protein kinase signal transduction pathway
-
Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556.
-
(1993)
J Biol Chem
, vol.268
, pp. 14553-14556
-
-
Davis, R.J.1
-
8
-
-
0027374550
-
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells
-
Graves LM, Bornfeldt KE, Raines EW, Potts BC, MacDonald SG, Ross R, and Krebs EG (1993) Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci USA 90:10300-10304.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10300-10304
-
-
Graves, L.M.1
Bornfeldt, K.E.2
Raines, E.W.3
Potts, B.C.4
MacDonald, S.G.5
Ross, R.6
Krebs, E.G.7
-
10
-
-
0025250142
-
Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cAMP- and cAMP-elevating vasodilators
-
Halbrügge M, Friedrich C, Eigenthaler M, Schanzenbacher P, and Walter U (1990) Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cAMP-and cAMP-elevating vasodilators. J Biol Chem 265:3088-3093.
-
(1990)
J Biol Chem
, vol.265
, pp. 3088-3093
-
-
Halbrügge, M.1
Friedrich, C.2
Eigenthaler, M.3
Schanzenbacher, P.4
Walter, U.5
-
11
-
-
0029842850
-
Pharmacokinetics of trapidil, an antagonist of platelet-derived growth factor, in healthy subjects and in patients with liver cirrhosis
-
Harder S, Thürmann PA, Hellstern A, and Benjaminov A (1996) Pharmacokinetics of trapidil, an antagonist of platelet-derived growth factor, in healthy subjects and in patients with liver cirrhosis. Br J Clin Pharmacol 42:443-449.
-
(1996)
Br J Clin Pharmacol
, vol.42
, pp. 443-449
-
-
Harder, S.1
Thürmann, P.A.2
Hellstern, A.3
Benjaminov, A.4
-
12
-
-
0025213191
-
Influence of trapidil and trapidil derivatives on the content of cyclic nucleotides in human intima cells cultured from atherosclerotic plaques
-
Heinroth-Hoffmann I, Krüger J, Tertov VV, Orekhov AN, and Mest H-J (1990) Influence of trapidil and trapidil derivatives on the content of cyclic nucleotides in human intima cells cultured from atherosclerotic plaques. Drug Dev Res 19:321-327.
-
(1990)
Drug Dev Res
, vol.19
, pp. 321-327
-
-
Heinroth-Hoffmann, I.1
Krüger, J.2
Tertov, V.V.3
Orekhov, A.N.4
Mest, H.-J.5
-
13
-
-
0031933969
-
Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade
-
Hoshiya M and Awazu M (1998) Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade. Hypertension 31:665-671.
-
(1998)
Hypertension
, vol.31
, pp. 665-671
-
-
Hoshiya, M.1
Awazu, M.2
-
14
-
-
0030835725
-
Activation of cAMP-PKA signalling in vivo inhibits smooth muscle cell proliferation induced by vascular injury
-
Indolfi C, Avvedimento EV, Di-Lorenzo E, Esposito G, Rapacciuolo A, Giuliano P, Grieco D, Cavuto L, Stingonge AM, Ciullo I, Condorelli G, and Chiarello M (1997) Activation of cAMP-PKA signalling in vivo inhibits smooth muscle cell proliferation induced by vascular injury. Nat Med 3:775-779.
-
(1997)
Nat Med
, vol.3
, pp. 775-779
-
-
Indolfi, C.1
Avvedimento, E.V.2
Di-Lorenzo, E.3
Esposito, G.4
Rapacciuolo, A.5
Giuliano, P.6
Grieco, D.7
Cavuto, L.8
Stingonge, A.M.9
Ciullo, I.10
Condorelli, G.11
Chiarello, M.12
-
15
-
-
0027326410
-
Protein kinase C-α activates RAF-1 by direct phosphorylation
-
Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, and Rapp U (1993) Protein kinase C-α activates RAF-1 by direct phosphorylation. Nature (Lond) 364:249-252.
-
(1993)
Nature (Lond)
, vol.364
, pp. 249-252
-
-
Kolch, W.1
Heidecker, G.2
Kochs, G.3
Hummel, R.4
Vahidi, H.5
Mischak, H.6
Finkenzeller, G.7
Marme, D.8
Rapp, U.9
-
16
-
-
0025275867
-
Trapidil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit
-
Liu MW, Roubin GS, Robinson KA, Black AJR, Hearn JA, Siegel RJ, and King III SB (1990) Trapidil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit. Circulation 81:1089-1093.
-
(1990)
Circulation
, vol.81
, pp. 1089-1093
-
-
Liu, M.W.1
Roubin, G.S.2
Robinson, K.A.3
Black, A.J.R.4
Hearn, J.A.5
Siegel, R.J.6
King III, S.B.7
-
17
-
-
0029025036
-
The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors
-
Malarkey K, Belham CM, Paul A, Graham A, McLees A, Scott PH, and Plevin R (1995) The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors. Biochem J 309:361-375.
-
(1995)
Biochem J
, vol.309
, pp. 361-375
-
-
Malarkey, K.1
Belham, C.M.2
Paul, A.3
Graham, A.4
McLees, A.5
Scott, P.H.6
Plevin, R.7
-
18
-
-
0028618228
-
Trapidil (Triazolopyrimidine), a platelet derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study
-
Maresta A, Balducelli M, Cantini L, Casari A, Chioin R, Fabbri M, Fontanelli A, Monici Preti PA, Repetto S, De Servi S, and Varani E (1994) Trapidil (Triazolopyrimidine), a platelet derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Circulation 90:2710-2715.
-
(1994)
Circulation
, vol.90
, pp. 2710-2715
-
-
Maresta, A.1
Balducelli, M.2
Cantini, L.3
Casari, A.4
Chioin, R.5
Fabbri, M.6
Fontanelli, A.7
Monici Preti, P.A.8
Repetto, S.9
De Servi, S.10
Varani, E.11
-
19
-
-
0029829858
-
High expression of the focal adhesion- and microfilament-associated protein VASP in vascular smooth muscle and endothelial cells of the intact human vessel wall
-
Markert T, Krenn V, Leebmann J, and Walter U (1996) High expression of the focal adhesion-and microfilament-associated protein VASP in vascular smooth muscle and endothelial cells of the intact human vessel wall. Basic Res Cardiol 91:337-343.
-
(1996)
Basic Res Cardiol
, vol.91
, pp. 337-343
-
-
Markert, T.1
Krenn, V.2
Leebmann, J.3
Walter, U.4
-
20
-
-
0027996763
-
Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: Reconstitution of the signalling pathway in vitro
-
Marquart B, Frith D, and Stabel S (1994) Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro. Oncogene 9:3213-3218.
-
(1994)
Oncogene
, vol.9
, pp. 3213-3218
-
-
Marquart, B.1
Frith, D.2
Stabel, S.3
-
21
-
-
0021174069
-
Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil
-
Mazurov AV, Menshikov MY, Leytin VL, Tkachuk VA, and Repin VS (1984) Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil. FEBS Lett 172:167-171.
-
(1984)
FEBS Lett
, vol.172
, pp. 167-171
-
-
Mazurov, A.V.1
Menshikov, M.Y.2
Leytin, V.L.3
Tkachuk, V.A.4
Repin, V.S.5
-
22
-
-
0029976573
-
cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition
-
McKenzie F and Pouysségur J (1996) cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition. J BM Chem 271:13476-13483.
-
(1996)
J BM Chem
, vol.271
, pp. 13476-13483
-
-
McKenzie, F.1
Pouysségur, J.2
-
23
-
-
0001010670
-
Signal transduction from membrane to cytoplasm: Growth factors and membrane-bound oncogene products increase RAF-1 phosphorylation and associated protein kinase activity
-
Morrison D, Kaplan DR, Rapp U, and Roberts TM (1988) Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase RAF-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci USA 85:8855-8859.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 8855-8859
-
-
Morrison, D.1
Kaplan, D.R.2
Rapp, U.3
Roberts, T.M.4
-
24
-
-
0028214075
-
Inhibition of PDGF receptor binding and PDGF-stimulated biological activity in vitro and of intimal lesion formation in vivo by 2-bromomethyl-5-chlorobenzene sulfonylphthalimide
-
Mullins D, Hamud F, Reim R, and Davis HR (1994) Inhibition of PDGF receptor binding and PDGF-stimulated biological activity in vitro and of intimal lesion formation in vivo by 2-bromomethyl-5-chlorobenzene sulfonylphthalimide. Arterioscler Thromb 14:1047-1055.
-
(1994)
Arterioscler Thromb
, vol.14
, pp. 1047-1055
-
-
Mullins, D.1
Hamud, F.2
Reim, R.3
Davis, H.R.4
-
26
-
-
0002481918
-
Preventive effects of trapidil (PDGF antagonist) on restenosis after PTCA
-
Nishikawa H, Ono N, and Motoyasu M (1992) Preventive effects of trapidil (PDGF antagonist) on restenosis after PTCA. Circulation 86:1-53.
-
(1992)
Circulation
, vol.86
, pp. 1-53
-
-
Nishikawa, H.1
Ono, N.2
Motoyasu, M.3
-
27
-
-
0021272656
-
Effects of trapidil and nitroglycerin on coronary circulation in conscious dogs
-
Noguchi K, Tomoike H, Kawachi Y, Nabeyama S, Shimokawa H, Maruoka Y, and Nakamura N (1984) Effects of trapidil and nitroglycerin on coronary circulation in conscious dogs. Arzneim-Forsch 34:872-876.
-
(1984)
Arzneim-Forsch
, vol.34
, pp. 872-876
-
-
Noguchi, K.1
Tomoike, H.2
Kawachi, Y.3
Nabeyama, S.4
Shimokawa, H.5
Maruoka, Y.6
Nakamura, N.7
-
28
-
-
0030570452
-
NF-kappa B is induced in the nuclei of cultured rat aortic smooth muscle cells by stimulation of various growth factors
-
Obata H, Biro S, Arima N, Kaieda H, Kihara T, Eto H, Miyata M, and Tanaka H (1996) NF-kappa B is induced in the nuclei of cultured rat aortic smooth muscle cells by stimulation of various growth factors. Biochem Biophys Res Commun 224:27-32.
-
(1996)
Biochem Biophys Res Commun
, vol.224
, pp. 27-32
-
-
Obata, H.1
Biro, S.2
Arima, N.3
Kaieda, H.4
Kihara, T.5
Eto, H.6
Miyata, M.7
Tanaka, H.8
-
29
-
-
0020464965
-
A new approach to treatment of atherosclerosis and trapidil as an antagonist to plateletderived growth factor
-
Ohnishi H, Yamaguchi K, Shimada S, Suzuki Y, and Kumagi A (1982) A new approach to treatment of atherosclerosis and trapidil as an antagonist to plateletderived growth factor. Life Sci 31:2595-2602.
-
(1982)
Life Sci
, vol.31
, pp. 2595-2602
-
-
Ohnishi, H.1
Yamaguchi, K.2
Shimada, S.3
Suzuki, Y.4
Kumagi, A.5
-
30
-
-
0026724049
-
Trapidil (triazolopyrimidine), a platelet-derived growth factor (PDGF) antagonist, in preventing restenosis after percutaneous transluminal coronary angioplasty
-
Okamoto S, Inden M, Setsuda M, Konishi T, and Nakano T (1992) Trapidil (triazolopyrimidine), a platelet-derived growth factor (PDGF) antagonist, in preventing restenosis after percutaneous transluminal coronary angioplasty. Am Heart J 123:1439-1444.
-
(1992)
Am Heart J
, vol.123
, pp. 1439-1444
-
-
Okamoto, S.1
Inden, M.2
Setsuda, M.3
Konishi, T.4
Nakano, T.5
-
31
-
-
0029900434
-
G-protein-coupled receptors and signaling pathways regulating growth responses
-
Post GR and Brown JH (1996) G-protein-coupled receptors and signaling pathways regulating growth responses. FASEB J 10:741-749.
-
(1996)
FASEB J
, vol.10
, pp. 741-749
-
-
Post, G.R.1
Brown, J.H.2
-
32
-
-
0027534090
-
Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis
-
Reines EW and Ross R (1993) Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis. Br Heart J 69:S30-S37.
-
(1993)
Br Heart J
, vol.69
-
-
Reines, E.W.1
Ross, R.2
-
33
-
-
0000417998
-
-
Fuster V, Ross R, and Topol EJ, eds Lippincott-Raven, Philadelphia
-
Ross R and Fuster V (1996) The pathogenesis of atherosclerosis, in Atherosclerosis and Coronary Artery Disease (Fuster V, Ross R, and Topol EJ, eds) pp 411-460, Lippincott-Raven, Philadelphia.
-
(1996)
The Pathogenesis of Atherosclerosis, in Atherosclerosis and Coronary Artery Disease
, pp. 411-460
-
-
Ross, R.1
Fuster, V.2
-
34
-
-
0027391553
-
Prostacyclin-dependent cyclic AMP formation in endothelial cells
-
Schröder H and Schrör K (1993) Prostacyclin-dependent cyclic AMP formation in endothelial cells. Naunyn-Schmiedebergs Arch Pharmacol 347:101-104.
-
(1993)
Naunyn-Schmiedebergs Arch Pharmacol
, vol.347
, pp. 101-104
-
-
Schröder, H.1
Schrör, K.2
-
35
-
-
0027530823
-
PDGF-induced mitogenic signaling is not mediated through protein kinase C and c-fos pathway in VSM cells
-
Sharma RV and Bhalla RC (1993) PDGF-induced mitogenic signaling is not mediated through protein kinase C and c-fos pathway in VSM cells. Am J Physiol 264:C71-C79.
-
(1993)
Am J Physiol
, vol.264
-
-
Sharma, R.V.1
Bhalla, R.C.2
-
36
-
-
0026453081
-
Activation of the c-Raf protein kinase by protein kinase C phosphorylation
-
Sözeri O, Vollmer K, Liyanage M, Frith D, Kour G, Mark GE III, and Stabel S (1992) Activation of the c-Raf protein kinase by protein kinase C phosphorylation. Oncogene 7:2259-2262.
-
(1992)
Oncogene
, vol.7
, pp. 2259-2262
-
-
Sözeri, O.1
Vollmer, K.2
Liyanage, M.3
Frith, D.4
Kour, G.5
Mark III, G.E.6
Stabel, S.7
-
37
-
-
0020958785
-
Suppression of fibroblast proliferation in vitro and of neointimal hyperplasia in vivo by the triazolopyrimidine, trapidil
-
Tiell ML, Sussmann II, Gordon PB, and Sanders RN (1983) Suppression of fibroblast proliferation in vitro and of neointimal hyperplasia in vivo by the triazolopyrimidine, trapidil. Artery 12:33-50.
-
(1983)
Artery
, vol.12
, pp. 33-50
-
-
Tiell, M.L.1
Sussmann, I.I.2
Gordon, P.B.3
Sanders, R.N.4
-
38
-
-
0027772672
-
Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate
-
Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, and Sturgill TW (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science (Washington DC) 262:1065-1069.
-
(1993)
Science (Washington DC)
, vol.262
, pp. 1065-1069
-
-
Wu, J.1
Dent, P.2
Jelinek, T.3
Wolfman, A.4
Weber, M.J.5
Sturgill, T.W.6
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