Different molecular motions in lyophilized protein formulations as determined by laboratory and rotating frame spin-lattice relaxation times

Journal of Pharmaceutical Sciences

Volumn 91, Issue 10, 2002, Pages 2203-2210

  Yoshioka, Sumie ^a   Aso, Yukio ^a   Kojima, Shigeo ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

1H solid state pulsed NMR; High resolution 13C solid state NMR; Lyophilized formulation; Molecular mobility; NMR relaxation time

Indexed keywords

BOVINE IMMUNOGLOBULIN; CARBENE; CARBON; DEXTRAN; GLASS; PROTON; RUBBER;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CORRELATION ANALYSIS; DRUG DETERMINATION; DRUG FORMULATION; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; HUMIDITY; LABORATORY TEST; MOLECULAR DYNAMICS; PROTON NUCLEAR MAGNETIC RESONANCE; RELAXATION TIME; SOLID STATE; TEMPERATURE DEPENDENCE; TIME;

EID: 0036784662     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10212     Document Type: Article

References (19)

1. Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes
2. Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in poly(vinyl pyrrolidone)
3. Bond cleavage reactions in solid aqueous carbohydrate solutions
4. Solid-state stability of human insulin II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: Stabilization against covalent dimer formation
5. Usefulness of the Kohlrausch-Williams-Watts stretched exponential function to describe protein aggregation in lyophilized formulations and the temperature dependence near the glass transition temperature
6. Effect of high molecular mobility of poly(vinyl alcohol) on protein stability of lyophilized γ-globulin formulations
7. Dependence of the molecular mobility and protein stability of freeze-dried γ-globulin formulations on the molecular weight of dextran
8. The relationship between protein aggregation and molecular mobility below the glass transition temperature of lyophilized formulations containing a monoclonal antibody
9. The glass transition of amylopectin measured by DSC, DMTA and NMR
10. A study of the glass transition of amylopectin-sugar mixtures
11. 1H NMR
12. Relation between a transition in molecular mobility and collapse phenomena in glucose-water systems
13. Determination of the glass transition temperature of food polymers using low field NMR
14. A study of the molecular motion in glucose/water mixtures using deuterium nuclear magnetic resonance
15. Formulation and stability of freeze-dried proteins: Effects of moisture and oxygen on the stability of freeze-dried formulations of human growth hormone
16. The Effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature
17. 13C solid-state NMR
18. 1 values by a method which suppresses artifacts
19. 13C CP/MAS NMR spectroscopy