New frontiers in molecular pediatric cardiology

Current Opinion in Pediatrics

Volumn 14, Issue 5, 2002, Pages 627-633

  Dees, Ellen ^a   Baldwin, H Scott ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; ENDOTHELIN A RECEPTOR; MESSENGER RNA; NEUROPILIN 1; PROTEIN; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG;

ALAGILLE SYNDROME; CELL MIGRATION; CLINICAL FEATURE; CONGENITAL HEART DISEASE; DIGEORGE SYNDROME; GENE MAPPING; GENETIC DISORDER; GENETIC LINKAGE; HEART DEVELOPMENT; HEART MUSCLE CELL; HOLT ORAM SYNDROME; HUMAN; MUTATION; NEURAL CREST; NONHUMAN; NOONAN SYNDROME; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; SIGNAL TRANSDUCTION;

AGE FACTORS; ANIMALS; CARDIOLOGY; CHILD; HEART DEFECTS, CONGENITAL; HUMANS; MICE; MOLECULAR BIOLOGY; ORGANOGENESIS; PEDIATRICS;

EID: 0036784444     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-200210000-00011     Document Type: Review

References (37)

1. Tbx1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome
2. Congenital heart disease in mice deficient for the DiGeorge syndrome region
3. Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice
4. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
5. Holt-Oram syndrome is caused by mutations in Tbx5, a member of the Brachyury (T) gene family
6. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
7. Mutations in human Tbx5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome
8. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
9. Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients
10. The DSL domain in mutant JAG1 ligand is essential for the severity of the liver defect in Alagille syndrome
11. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
12. A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
13. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension
14. BMP type II receptor is required for gastrulation and early development of mouse embryos
15. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
16. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis
17. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
18. PTPN11 mutations in Noonan syndrome: Molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity
19. The anterior heart-forming field: Voyage to the arterial pole of the heart
20. The outflow tract of the heart is recruited from a novel heart-forming field
21. Conotruncal myocardium arises from a secondary heart field
22. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm
23. Neural crest and cardiovascular patterning
24. Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption
25. PlexinA2 and semaphorin signaling during cardiac neural crest development
26. Visualization and functional characterization of the developing murine cardiac conduction system
27. The role of Engrailed in establishing the dorsoventral axis of the chick limb
28. Sodium-calcium exchanger (NCX-1) and calcium modulation: NCX protein expression patterns and regulation of early heart development
29. Inhibitory effects of ouabain on early heart development and cardiomyogenesis in the chick embryo
30. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization
31. Myocyte proliferation in end-stage cardiac failure in humans
32. Evidence that human cardiac myocytes divide after myocardial infarction
33. Myocyte renewal and ventricular remodelling
34. Regulation of muscle transcription by the MyoD family. The heart of the matter
35. Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts
36. Chimerism of the transplanted heart
37. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart