Interferon-γ activates EGF receptor and increases TGF-α in T84 cells: Implications for chloride secretion

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 4 46-4, 2002, Pages

  Uribe, Jorge M ^a   McCole, Declan F ^a   Barrett, Kim E ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

Chloride secretion; Cytokines; Growth factors; Inflammation; Mucosal injury

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CARBACHOL; CHLORIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA INTERFERON; NEUTRALIZING ANTIBODY; PROTEIN TYROSINE KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; ATTENUATION; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0036784249     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00237.2002     Document Type: Article

References (35)

1. INF-gamma modulation of epithelial barrier function: Time course, reversibility, and site of cytokine binding
2. Interferon-gamma induces prostaglandin G/H synthase through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells
3. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
4. 84 cells
5. Interferon-gamma downregulates CFTR gene expression in epithelial cells
6. Immunomodulatory properties of interferon-gamma: An update
7. Expression of epidermal growth factor and epidermal growth factor receptor genes in healing colonic anastomoses in rats
8. Transforming growth factor-α abrogates glucocorticoid-stimulated tight junction formation and growth factor suppression in rat mammary epithelial cells
9. Somatotropin inhibits intestinal chloride secretion: Mechanisms and role in Crohn's disease therapy
10. A role for protein kinase Cε in the inhibitory effect of epidermal growth factor on calcium-stimulated chloride secretion in human colonic epithelial cells
11. Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells
12. - cotransport system
13. Mechanisms of chloride secretion induced by carbachol in a colonic epithelial cell line
14. Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin 8
15. 84 cell function
16. src
17. 84 cells: Implications for carbachol-stimulated chloride secretion
18. Cytokine signal transduction
19. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers
20. Transforming growth factor-α. A model for membrane-anchored growth factors
21. Carbachol transactivation of the EGF receptor in T84 cells requires TGF-α release
22. Epidermal growth factor-dependent activation of Src family kinases
23. Increased production of transforming growth factor alpha following acute gastric injury
24. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
25. Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
26. Association of the transmembrane TGF-α, precursor with a protein kinase complex
27. Cytokine regulated expression of platelet-derived growth factor gene and protein in cultured human astrocytes
28. Up-regulation of transforming growth factor α binding sites in experimental rabbit colitis
29. +-ATPase by interferon-gamma down-regulates intestinal epithelial transport and barrier function
30. Non-mitogenic actions of growth factors: An integrated view of their role in intestinal physiology and pathophysiology
31. 84 human colonic epithelial cells
32. Phosphatidylinositol 3-kinase mediates the inhibitory effect of epidermal growth factor on calcium-dependent chloride secretion
33. EGF receptor
34. Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
35. Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion