PKC-ζ prevents oxidant-induced iNOS upregulation and protects the microtubules and gut barrier integrity

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 4 46-4, 2002, Pages

  Banan, A ^a   Zhang, L ^b   Fields, J Z ^b   Farhadi, A ^a   Talmage, D A ^a   Keshavarzian, A ^b  

^a RUSH UNIVERSITY   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Growth factors; Inflammatory bowel disease; Molecular biology; Nitrogen metabolites; Oxidative stress; Tubulin cytoskeleton

Indexed keywords

ANTIOXIDANT; EPIDERMAL GROWTH FACTOR; HYDROGEN PEROXIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ZETA; TUBULIN;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOARCHITECTURE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROTUBULE; MONOLAYER CULTURE; NITRATION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION; REGULATORY MECHANISM; STOMACH INJURY; STOMACH PROTECTION; WILD TYPE;

EID: 0036784217     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00143.2002     Document Type: Article

References (67)

1. Protein kinase C-α modulates growth and differentiation in Caco-2 cells
2. Protein kinase C modulator effects on parathyroid hormone-induced intracellular calcium and morphologic changes in UMR 106-H5 osteoblastic cells
3. Assembly of the tight junction. The role of diacylglycerol
4. Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: Evidence for oxidative and cytoskeletal mechanisms
5. Role of the microtubule cytoskeleton in protection by epidermal growth factor and transforming growth factor-α against oxidant-induced barrier disruption in a human colonic cell line
6. The beta 1 isoform of protein kinase C mediates the protective effects of epidermal growth factor on the dynamic assembly of F-actin cytoskeleton and normalization of calcium homeostasis in human colonic cells
7. The β1 isoform of protein kinase C mediates epidermal growth factor protection of the microtubules and barrier integrity of intestinal monolayers against oxidant damage
8. The atypical PKC-ζ isoform is required in protection of microtubules and intestinal barrier integrity
9. Key role of general protein kinase C activation in EGF-induced protection of the microtubule cytoskeleton and intestinal epithelial barrier against oxidant injury
10. Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction
11. Targeted molecular inhibition of phospholipase C-γ prevents EGF-mediated protection of the microtubule cytoskeleton and intestinal epithelial barrier function against oxidant injury
12. iNOS upregulation mediates oxidant-induced disruption of F-actin and the permeability barrier of intestinal monolayers
13. Polyamines are required for microtubule formation during mucosal ulcer healing
14. Protection against ethanol injury by prostaglandins in a human intestinal cell line: Role of microtubules
15. Relationship between polyamines, cytoskeletal distribution, and gastric mucosal ulcer healing in rats
16. Increased oxidation and nitration injury in intestinal mucosa of patients with inflammatory bowel disease
17. Carbonylation and disassembly of the F-actin in oxidant-induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor-α in a human intestinal cell line
18. G protein kinase C-alpha activity inversely modulates invasion and growth of intestinal cells
19. Role of protein kinase C in modulating epidermal growth factor- and phorbol ester-induced mammary epithelial cell growth in vitro
20. Expression of four protein kinase C isoforms in rat fibroblasts
21. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye binding
22. Nitric oxide synthase regulatory sites
23. The role of protein kinase C isozymes in TNF-α-induced cytotoxicity to a rat intestinal epithelial cell line
24. Essential role of NF-kappa B activation in silica-induced inflammatory mediator production in macrophages
25. Distinct functions of protein kinase C-alpha and protein kinase C-beta during retinoic acid-induced differentiation of F 9 cells
26. Arachidonate initiated protein kinase C activation regulates HeLa cell spreading on a gelatin substrate by inducing F-actin formation and exocytotic upregulation of beta 1 integrin
27. Cellular variability in the development of tight junction after activation of protein kinase C
28. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
29. Microtubule organization and its involvement in the biogenic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells
30. Immunocytochemical localization of eight PKC isoenzymes overexpressed in NIH 3T3 fibroblasts
31. Protein kinase C signaling and oxidative stress
32. Critical values for Dunnett's new multiple range test
33. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin
34. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
35. The intestinal permeability barrier: A hypothesis as to its regulation and involvement in Crohn's disease
36. Crohn's disease - A permeability disorder of the tight junction?
37. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts
38. Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrosulfate: Assessment of effect-reversibility and imaging of transepithelial transport routes by laser confocal microscopy
39. Reactive species in ischemic rat lung injury: Contribution of peroxynitrite
40. Protein kinase C activation during corneal endothelial wound repair
41. Poly (ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells
42. Increased colonic free radicals and oxidation and nitration injury to key cytoskeletal proteins in inflammatory bowel disease
43. Leaky gut in alcoholic cirrhosis: A possible mechanism for alcohol induced liver damage
44. Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe
45. Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
46. Towards an understanding of microtubule function and cell organization: An overview
47. Increased transforming growth factor-alpha levels in human colon carcinoma cell lines over-expressing protein kinase C
48. Evidence for oxidant-induced injury to epithelial cells during inflammatory bowel disease
49. The alpha isoform of protein kinase C inhibits histamine-stimulated adenylate cyclase activity in a particulate fraction of the human gastric cancer cell line HGT-1
50. Introduction of the β isozyme of protein kinase C accelerates induced differentiation of murine erythroleukemia cells
51. The human intestinal epithelial cell line Caco-2: Pharmacological and pharmacokinetics applications
52. Protein kinase C-α and -β in NIH 3T3 cells induce opposite effects on growth morphology, anchorage dependence, and tumorigenicity
53. Protein kinase C-delta increases tight junction permeability in LLC-PK1 cells
54. Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts by protein kinase C
55. Protein kinase C isoenzymes in human neuroblasts: Involvement of PKC-α in cell differentiation
56. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease
57. Differential induction of phosphotidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by EGF and TGF-alpha in normal human skin fibroblasts and keratinocytes
58. Assessment of inflammatory events in epithelial permeability: A rapid screening method using fluorescein dextrans
59. Activation of protein kinase C is associated with post-mitotic events in intestinal epithelial cells in situ
60. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
61. Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activator
62. PKC-dependent regulation of transepithelial resistance: Roles of MLC and MLC kinase
63. Hyperperme-ability of intestinal epithelial monolayers induced by NO: Effect of low extracellular pH
64. Thrombin and phorbol myristate acetate stimulate cytoskeletal polymerization in quiescent cells: A potential link to mitogenesis
65. Epidermal growth factor inhibits carbachol stimulated canine parietal cell function via protein kinase C
66. Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats
67. Defective microtubule reorganization in phorbol ester-resistant U937 variant: Reconstitution of the normal cell phenotype with nocodazole treatment