Sensitization by extracellular Ca2+ of rat P2X5 receptor and its pharmacological properties compared with rat P2X1

Molecular Pharmacology

Volumn 62, Issue 4, 2002, Pages 957-966

  Wildman, Scott S ^a   Brown, Sean G ^b   Rahman, Mary ^b   Noel, Carole A ^a   Churchill, Linda ^a   Burnstock, Geoffrey ^a,b   Unwin, Robert J ^a   King, Brian F ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; 2' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; 2',3' O (2,4,6 TRINITROPHENYL)ADENOSINE TRIPHOSPHATE; 3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BARIUM ION; CALCIUM ION; CIBACRON BLUE F3GA; DIADENOSINE TETRAPHOSPHATE; DIINOSINE PENTAPHOSPHATE; GUANOSINE TRIPHOSPHATE; ION CHANNEL; MAGNESIUM ION; PROTON; PURINE P2X RECEPTOR; PURINE P2X1 RECEPTOR; PURINE P2X5 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; RECOMBINANT RECEPTOR; SURAMIN; UNCLASSIFIED DRUG; ZINC ION;

AGONIST; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CELL PH; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG RESPONSE; DRUG SELECTIVITY; EXTRACELLULAR CALCIUM; FEMALE; INCUBATION TIME; MODULATION; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; ELECTROPHYSIOLOGY; IMMUNOHISTOCHEMISTRY; OOCYTES; RATS; RECEPTORS, PURINERGIC P2; TRANSFECTION; XENOPUS LAEVIS; ZINC;

EID: 0036783692     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.4.957     Document Type: Article

References (40)

1. Bailey MA, Hillman KA, and Unwin RJ (2000) P2 receptors in the kidney. J Auton Nerv Syst 81:264-270.
2. Bobanovic LK, Royle SJ, and Murrell-Lagnado RD (2002) P2X receptor trafficking in neurons is subunit specific. J Neurosci 22:4814-4824.
3. 4 nucleotide receptor. Br J Pharmacol 124:428-430.
4. 2 ATP-gated channels. J Biol Chem 275:10190-10195.
5. Brändle U, Guenther E, Irrle C, and Wheeler-Schilling TH (1998) Gene expression of the P2X receptors in the rat retina. Brain Res Mol Brain Res 59:269-272.
6. 1/2 receptors show a novel sensitivity to extracellular pH. J Pharmacol Exp Ther 300:673-680.
7. Burnstock G and King BF (1996) Numbering of cloned P2 receptors. Drug Dev Res 38:67-71.
8. 6 receptors along the normal rat nephron (Abstract). J Am Soc Nephrol 9:420A.
9. 6 receptors, and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495-2507.
10. 2+-dependent modulation of ATP-gated P2X receptors in nociceptors. Neuropharmacol 36:1303-1308.
11. 2+ by speeding recovery of P2X receptors from desensitization. J Neurosci 18:9238-9244.
12. 1 receptor membrane redistribution and down regulation visualized by using receptor-coupled green fluorescent protein chimeras. Neuropharmacol 39:2054-2066.
13. 1 in rat vas deferens. FEBS Lett 489:154-158.
14. Garcia-Guzman M, Soto F, Laube B, and Stühmer W (1996) Molecular cloning and functional expression of a novel rat heart P2X purinoceptor. FEBS Lett 388:123-127.
15. Gitterman DP and Evans RJ (2000) Properties of P2X and P2Y receptors are dependent on artery diameter in the rat mesenteric bed. Br J Pharmacol 131:1561-1568.
16. 7 receptors by immunohistochemistry in rat stratified squamous epithelia. Cell Tissue Res 296:599-605.
17. 5 isoforms. Mol Pharmacol 56:720-727.
18. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Séguéla P, Voigt M, and Humphrey PPA (2001a) International union of pharmacology. XXIV. Current status on the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53:107-118.
19. 2-green fluorescent protein receptors. Proc Natl Acad Sci USA 98:5288-5293.
20. 2, an ATP-gated ion channel. Biochem Biophys Res Commun 240:618-622.
21. King B, Chen CC, Akopian AN, Burnstock G, and Wood JN (1997) A role for calcineurin in the desensitization of the P2X3 receptor. Neuroreport 8:1099-1102.
22. 5 subunits. J Biol Chem 274:15415-15419.
23. Li GH, Lee EM, Blair D, Holding C, Poronnik P, Cook DI, Barden JA, and Bennett MR (2000) The distribution of P2X receptor clusters on individual neurons in sympathetic ganglia and their redistribution on agonist activation. J Biol Chem 275:29107-29112.
24. 2 receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons. J Pharmacol Exp Ther 296:1043-1050.
25. 3 form stable trimers: a novel structural motif ligand-gated ion channel. EMBO (Eur Mol Biol Organ) J 17:3016-3028.
26. Phillips JK and Hill CE (1999) Neuroceptor mRNA expression in the rat mesenteric artery develops independently of innervation. Int J Dev Neurosci 17:377-386.
27. Phillips JK, McLean AJ, and Hill CE (1998) Receptors involved in nerve-mediated vasoconstriction in small arteries of the rat hepatic mesentery. Br J Pharmacol 124:1403-1412.
28. Ralevic V and Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413-492.
29. Ruppelt A, Liang BT, and Soto F (2001) Cloning, functional characterization and developmental expression of a P2X receptor from chick embryo. Prog Brain Res 120:81-90.
30. Ryten M, Hoebertz A, and Burnstock G (2001) Sequential expression of three receptor subtypes for extracellular ATP in developing rat skeletal muscle. Devel Dynamics 221:331-341.
31. Schwiebert EM (2001) ATP release mechanisms, ATP receptor and purinergic signalling along the nephron. Clin Exp Pharm Phys 28:340-350.
32. Schwiebert EM and Kishore BK (2001) Extracellular nucleotide signaling along the renal epithelium. Am J Ren Physiol 280:F945-F963.
33. Skeberdis VA, Lan JY, Opitz T, Zheng X, Bennett MVL, and Zukin RS (2001) MGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C. Neuropharmacol 40:856 -865.
34. 1/5 receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles. J Auton Nerv Syst 81:249-263.
35. Taylor AL, Schwiebert LM, Smith JJ, King C, Jones JR, Sorscher EJ, and Schwiebert EM (1999) Epithelial P2X purinergic receptor channel expression and function. J Clin Invest 104:875-884.
36. Torres GE, Egan TM, and Voigt MM (1999) Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners. J Biol Chem 274:6653-6659.
37. 5 receptor subunits reveals a novel ATP-gated ion channel. Mol Pharmacol 54:989-993.
38. 6A in the isolated perfused rat kidney. Brit J Pharmacol 127:1463-1469.
39. 1 receptor, but operationally different (Abstract). Pfleug Arch Eur J Physiol 443:S229.
40. 3 receptors. Br J Pharmacol 128:486-492.