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Synthesis and biological evaluation of 5-[3,5-bis(1,1-dimethyl-ethyl)-4-hydroxyphenyl]methyleneoxazoles, -thiazoles, and -imidazoles: Novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity
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Unangst, P.C., Connor, D.T., Cetenko, W.A., Sorenson, R.J., Kostlan, C.R., Sircar, J.C., Wright, C.D., Schrier, D.J., Dyer, R.D. Synthesis and biological evaluation of 5-[3,5-bis(1,1-dimethyl-ethyl)-4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: Novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity. J Med Chem 1994, 37: 322-8.
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Lornoxicam, a new NSAID with an improved tolerability profile
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Biochemical pharmacology of PD 136095, a novel inhibitor of arachidonic acid metabolism
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Dyer, R.D., Bornemeier, D.A., Cetenko, W.A., Ferin, M.A., Kuipers, P.J., Lesch, M.E., Schrier, D.J., Sircar, J.C., Wright, C.D. Biochemical pharmacology of PD 136095, a novel inhibitor of arachidonic acid metabolism. 6th Int Conf Inflamm Res Assoc (Sept 20-24, Pennsylvania) 1992, Abst P105.
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Fujimori, T., Connor, D.T., Cetenko, W.A., Marletta, M.A., Hupe, D.J., Dyer, R.D. A novel antiinflammatory compound extends the lag phase of prostaglandin H synthase-2 (PGHS-2) kinetics. FASEB J 1996, 10(6): Abst 1495.
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Phosphodiesterase (PDE)-3 and PDE-4 inhibition by the antiinflammatory drug darbufelone
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Schrier, D.J., Cetenko, W.A., Dyer, R.D., Kuchera, S., Imre, K., Lesch, M.E., Okonkwo, G.C.N., Sircar, J.C., Wright, C., Conroy, M.C. The antiinflammatory and analgesic effects of (Z)-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-imino-4- thiazolidinone (PD 136095), a novel dual inhibitor of 5-lipoxygenase and cyclooxygenase. 6th Int Conf Inflamm Res Assoc (Sept 20-24, Pennsylvania) 1992, Abst P112.
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Guglietta, A., Lesch, C.A., Kraus, E.R., Dyer, R., Schrier, D., Sanchez, B. Effect of PGHS-2 inhibitors and other antiinflammatory drugs on healing of acetic acid-induced ulcer in rats. Dig Dis Week (May 10-16, Washington DC) 1997, Abst 4329.
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Early preclinical pharmacokinetics and antiinflammatory pharmacodynamics of PD 136095
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Guttendorf, R.J., Andress, L., Okonkwo, G., Lesch, M., Finkel, M., Schrier, D., Loewen, G. Early preclinical pharmacokinetics and antiinflammatory pharmacodynamics of PD 136095. 6th Int Conf Inflamm Res Assoc (Sept 20-24, Pennsylvania) 1992, Abst P122.
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Andress, L.D., Guttendorf, R.J. Pharmacokinetics (PK) and bioavailability of CI-1004, a novel antiinflammatory drug, in dogs. Pharm Res 1994, 11(10, Suppl.): Abst PPDM 8063.
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