Concern over the amyloid vaccine: Amyloid heterogeneity and Fc receptor signaling

Neurobiology of Aging

Volumn 23, Issue 5, 2002, Pages 667-670

  Bruce Keller, Annadora J ^a   Estus, Steven ^b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; COMPLEMENT COMPONENT C3; FC RECEPTOR; INTERLEUKIN 6;

ALZHEIMER DISEASE; ANTIBODY PRODUCTION; BEHAVIOR; BRAIN REGION; CELL LOSS; DISEASE COURSE; DRUG EFFECT; HUMAN; IMMUNIZATION; IMMUNOCYTOCHEMISTRY; MEMORY; MICROGLIA; NONHUMAN; NOTE; OXIDATIVE STRESS; PRIORITY JOURNAL; SENILE PLAQUE; SIGNAL TRANSDUCTION;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; HUMANS; IMMUNOTHERAPY, ACTIVE; RECEPTORS, FC; SIGNAL TRANSDUCTION;

EID: 0036752021     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(02)00032-5     Document Type: Note

References (38)

1. Aderem A., Underhill D.M. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 17:1999;593-623.
2. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G.et al. Inflammation and Alzheimer's disease. Neurobiol. Aging. 21:2000;383-421.
3. Bacskai B.J., Kajdasz S.T., Christie R.H., Carter C., Games D., Seubert P.et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat. Med. 7:2001;369-372.
4. Bajtay Z., Falus A., Erdei A., Gergely J. Fc gamma R-dependent regulation of the biosynthesis of complement C3 by murine macrophages: the modulatory effect of IL-6. Scand. J. Immunol. 35:1992;195-201.
5. Benveniste E.N., Nguyen V.T., O'Keefe G.M. Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem. Int. 39:2001;381-391.
6. Berezovskaya O., Maysinger D., Fedoroff S. The hemapoietic cytokine, colony stimulating factor 1, is also a growth factor in the CNS: congenetal absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int. J. Dev. Neurosci. 13:1995;285-299.
7. Butterfield D.A., Drake J., Pocernich C., Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol. Med. 7:2001;548-554.
8. Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82:2002;47-95.
9. Emmerling M.R., Watson M.D., Raby C.A., Spiegel K. The role of complement in Alzheimer's disease pathology. Biochim. Biophys. Acta. 1502:2000;158-171.
10. Ernst R.L., Hey J.W. The US economic and social costs of Alzheimer's disease revisited. Am. J. Pub. Health. 84:1994;1264.
11. Forman H.J., Torres M. Redox signaling in macrophages. Mol. Aspects Med. 22:2001;189-216.
12. Hock B.J., Lamb B.T. Transgenic mouse models of Alzheimer's disease. Trends Genet. 17:2001;S7-S12.
13. Hsiao K. Transgenic mice expressing Alzheimer amyloid precursor proteins. Exp. Gerontol. 33:1998;883-889.
14. Irizarry M.C., McNamara M., Fedorchak K., Hsiao K., Hyman B.T. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol. 56:1997;965-973.
15. Irizarry M.C., Soriano F., McNamara M., Page K.J., Schenk D., Games D.et al. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17:1997;7053-7059.
16. Iversen L.L., Mortishire-Smith R.J., Pollack S.J., Shearman M.S. The toxicity in vitro of beta-amyloid protein. Biochem. J. 311:1995;1-16.
17. Klegeris A., Schwab C., Bissonnette C.J., McGeer P.L. Induction of complement C9 messenger RNAs in human neuronal cells by inflammatory stimuli: relevance to neurodegenerative disorders. Exp. Gerontol. 36:2001;1179-1188.
18. Klein W.L., Krafft G.A., Finch C.E. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci. 24:2001;219-224.
19. Lazarov-Spiegler O., Solomon A.S., Zeev-Brann A.B., Hirschberg D.L., Lavie V., Schwartz M. Transplantation of activated macrophages overcomes central nervous system regrowth failure. FASEB J. 10:1996;1296-1302.
20. McGeer P.L., Itagaki S., Tago H., McGeer E.G. Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci. Lett. 79:1987;195-200.
21. McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease. Neurology. 47:1996;425-432.
22. Melendez A.J., Bruetschy L., Floto R.A., Harnett M.M., Allen J.M. Functional coupling of FcgammaRI to nicotinamide adenine dinucleotide phosphate (reduced form) oxidative burst and immune complex trafficking requires the activation of phospholipase D1. Blood. 98:2001;3421-3428.
23. Morgan D., Diamond D.M., Gottschall P.E., Ugen K.E., Dickey C., Hardy J.et al. Amyloid beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408:2000;982-985.
24. Morikawa M., Harada N., Nunomura Y., Koike T., Hashimoto S., Soma G.et al. Fc gamma receptor-mediated biological activities of human leukemic cell lines and their modulation by transforming growth factor-beta 1 and interleukin-6. Cytokine. 5:1993;255-263.
25. Mucke L., Masliah E., Yu G.Q., Mallory M., Rockenstein E.M., Tatsuno G.et al. High-level neuronal expression of amyloid beta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20:2000;4050-4058.
26. Nauseef W. The NADPH-dependent oxidase of phagocytes. Proc. Assoc. Am. Physicians. 111:1999;373-382.
27. Pratico D., Delanty N. Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am. J. Med. 109:2000;577-585.
28. Prewitt C.M., Niesmann I.R., Kane C.J.M., Houle J.D. Activated macrophage/microglial cells can promote the regeneration of sensory axons into the injured spnial cord. Exp. Neurol. 148:1997;433-443.
29. Rabchevsky A.G., Streit W.J. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth. J. Neurosci. Res. 47:1997;34-48.
30. Sankarapandi S., Zweier J., Mukherjee G., Quinn M., Huso D. Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway. Arch. Biochem. Biophys. 353:1998;312-321.
31. Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guido T.et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 400:1999;173-177.
32. Shastry B.S. Molecular and cell biological aspects of Alzheimer disease. J. Hum. Genet. 46:2001;609-618.
33. Shimohama S., Tanino H., Kawakami N., Okamura N., Kodama H., Yamaguchi T.et al. Activation of NADPH oxidase in Alzheimer's disease brains. Biochem. Biophys. Res. Commun. 273:2000;5-9.
34. Sorbi S., Forleo P., Tedde A., Cellini E., Ciantelli M., Bagnoli S.et al. Genetic risk factors in familial Alzheimer's disease. Mech. Ageing Dev. 122:2001;1951-1960.
35. Stangel M., Compston A. Polyclonal immunoglobulins (IVIg) modulate nitric oxide production and microglial functions in vitro via Fc receptors. J. Neuroimmunol. 112:2001;63-71.
36. Tang T., Rosenkranz A., Assmann K.J., Goodman M.J., Gutierrez-Ramos J.C., Carroll M.C.et al. A role for Mac-1 (CD11b/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J. Exp. Med. 186:1997;1853-1863.
37. Toku K., Tanaka J., Yano H., Desaki J., Zhang B., Yang L.et al. Microglial cells prevent nitric oxide-induced neuronal apoptosis in vitro. J. Neurosci. Res. 53:1998;415-425.
38. van Spriel A.B., Leusen J.H., van Egmond M., Dijkman H.B., Assmann K.J., Mayadas T.N.et al. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood. 97:2001;2478-2486.