In vivo effect of 5- and 8-methoxypsoralens and cimetidine on R,S-warfarin metabolism in rat

Journal of Applied Toxicology

Volumn 22, Issue 5, 2002, Pages 327-332

  Baldrick, Paul ^a   Richardson, Derek ^b   Wheeler, Alan W ^b  

^a UK   (United Kingdom)

^b Allergy Therapeutics Ltd   (United Kingdom)

Author keywords

5 methoxypsoralen; 8 methoxypsoralen; Cimetidine; CYP 2C11; CYP 2C6; Kinetics; Metabolic probes inhibitors; R.S warfarin

Indexed keywords

BERGAPTEN; CIMETIDINE; CYTOCHROME P450; CYTOCHROME P450 2C11; DRUG METABOLITE; GLYCOPROTEIN P; ISOENZYME; METHOXSALEN; QUINIDINE; WARFARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG INHIBITION; DRUG MECHANISM; DRUG METABOLISM; DRUG WITHDRAWAL; ENANTIOMER; ENZYME ACTIVITY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ANIMALS; ANTICOAGULANTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIMETIDINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; MALE; METHOXSALEN; RATS; RATS, WISTAR; STEREOISOMERISM; WARFARIN;

EID: 0036746746     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.867     Document Type: Article

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