-
1
-
-
0027285238
-
Lowdose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis
-
Shiroky JB, Neville C, Esdaile JM, Choquette D, Zummer M, Hzeltine M, et al. Lowdose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis. Arthritis Rheum 1993; 36: 795-803
-
(1993)
Arthritis Rheum
, vol.36
, pp. 795-803
-
-
Shiroky, J.B.1
Neville, C.2
Esdaile, J.M.3
Choquette, D.4
Zummer, M.5
Hzeltine, M.6
-
2
-
-
0025037994
-
The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis
-
Morgan SL, Baggott JE, Vaughn WH, Young PK, Austin JV, Krumdieck CL, Alarcon GS. The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis. Arthritis Rheum 1990; 33: 918
-
(1990)
Arthritis Rheum
, vol.33
, pp. 918
-
-
Morgan, S.L.1
Baggott, J.E.2
Vaughn, W.H.3
Young, P.K.4
Austin, J.V.5
Krumdieck, C.L.6
Alarcon, G.S.7
-
4
-
-
0029157365
-
Methotrexate action in rheumatoid arthritis: Stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells
-
Seitz M, Loetschler P, Dewald B, Towbin H, Rordorf C, Gallati H, Baggiolini M. Methotrexate action in rheumatoid arthritis: Stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells. Br J Rheumatol 1995; 34: 602-609
-
(1995)
Br J Rheumatol
, vol.34
, pp. 602-609
-
-
Seitz, M.1
Loetschler, P.2
Dewald, B.3
Towbin, H.4
Rordorf, C.5
Gallati, H.6
Baggiolini, M.7
-
5
-
-
0027507790
-
Elevated levels of TNF in the joints of adjuvant arthritic rats
-
Smith-Oliver T, Noel LS, Stimpson SS, Yarnall DP, Connolly KM. Elevated levels of TNF in the joints of adjuvant arthritic rats. Cytokine 1993; 5: 298-304
-
(1993)
Cytokine
, vol.5
, pp. 298-304
-
-
Smith-Oliver, T.1
Noel, L.S.2
Stimpson, S.S.3
Yarnall, D.P.4
Connolly, K.M.5
-
6
-
-
0030664737
-
The mechanism of action of methotrexate
-
Cronstein BN. The mechanism of action of methotrexate. Rheum Dis Clin North Am 1997; 23: 739-755
-
(1997)
Rheum Dis Clin North Am
, vol.23
, pp. 739-755
-
-
Cronstein, B.N.1
-
7
-
-
0030064262
-
Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro
-
Chong AS, Rezai K, Gebel HM, Finnegan A, Foster P, Xu X, Williams JW. Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro. Transplantation 1996; 61: 140-145
-
(1996)
Transplantation
, vol.61
, pp. 140-145
-
-
Chong, A.S.1
Rezai, K.2
Gebel, H.M.3
Finnegan, A.4
Foster, P.5
Xu, X.6
Williams, J.W.7
-
8
-
-
0029591467
-
The immunosuppressant leflunomide inhibitis lymphocyte proliferation by inhibiting pyrimidine biosynthesis
-
Cherwinski HM, Cohn RG, Cheung P, Webster DJ, Xu YZ, Caulfield JP, Young JM, Nakano G, Ransom JT. The immunosuppressant leflunomide inhibitis lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995; 275: 1043-1049
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1043-1049
-
-
Cherwinski, H.M.1
Cohn, R.G.2
Cheung, P.3
Webster, D.J.4
Xu, Y.Z.5
Caulfield, J.P.6
Young, J.M.7
Nakano, G.8
Ransom, J.T.9
-
9
-
-
0029913383
-
Regulation of B cell function by the immunosuppressive agent leflunomide
-
Siemasko KF, Chong AS, Williams JW, Bremer EG, Finnegan A. Regulation of B cell function by the immunosuppressive agent leflunomide. Transplantation 1996; 61: 635-641
-
(1996)
Transplantation
, vol.61
, pp. 635-641
-
-
Siemasko, K.F.1
Chong, A.S.2
Williams, J.W.3
Bremer, E.G.4
Finnegan, A.5
-
10
-
-
0029050136
-
Inhibition of dihydro-orotate dehydrogenase by the immunosuppressive agent leflunomide
-
Greene S, Watanabe K, Braatz-Trulson J, Lou L. Inhibition of dihydro-orotate dehydrogenase by the immunosuppressive agent leflunomide. Biochem Pharmacol 1995; 50: 861-867
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 861-867
-
-
Greene, S.1
Watanabe, K.2
Braatz-Trulson, J.3
Lou, L.4
-
11
-
-
0029022389
-
Combination therapy with cyclosporin and methotrexate in severe rheumatoid arthritis
-
The Methotrexate-Cyclosporin Combination Study Group
-
Tugwell P, Pincus T, Yocum D, Stein M, Gluck D, Kraag G, McKendry R, Tesser J, Baker P, Wells G. Combination therapy with cyclosporin and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporin Combination Study Group. N Engl J Med 1995; 333: 137-141
-
(1995)
N Engl J Med
, vol.333
, pp. 137-141
-
-
Tugwell, P.1
Pincus, T.2
Yocum, D.3
Stein, M.4
Gluck, D.5
Kraag, G.6
McKendry, R.7
Tesser, J.8
Baker, P.9
Wells, G.10
-
12
-
-
15144356729
-
Combination treatment of severe rheumatoid arthritis with cyclosporin and methotrexate for forty-eight weeks: An open-label extension study
-
The Methotrexate-Cyclosporin Combination Study Group
-
Stein CM, Pincus T, Yocum D, Tugwell P, Wells G, Gluck D, Kraager G, Torley H, Tesser J, McKendry R, Brooks RH. Combination treatment of severe rheumatoid arthritis with cyclosporin and methotrexate for forty-eight weeks: an open-label extension study. The Methotrexate-Cyclosporin Combination Study Group. Arthritis Rheum 1997; 40: 1843-1851
-
(1997)
Arthritis Rheum
, vol.40
, pp. 1843-1851
-
-
Stein, C.M.1
Pincus, T.2
Yocum, D.3
Tugwell, P.4
Wells, G.5
Gluck, D.6
Kraager, G.7
Torley, H.8
Tesser, J.9
McKendry, R.10
Brooks, R.H.11
-
13
-
-
0029939391
-
Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate
-
O'Dell JR, Haire C, Erikson N, Drymalski W, Palmer W, Maloley P, Klassen LW, Wees S, Moore GF. Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate. J Rheumatol Suppl 1996; 44: 72-74
-
(1996)
J Rheumatol Suppl
, vol.44
, pp. 72-74
-
-
O'Dell, J.R.1
Haire, C.2
Erikson, N.3
Drymalski, W.4
Palmer, W.5
Maloley, P.6
Klassen, L.W.7
Wees, S.8
Moore, G.F.9
-
14
-
-
0031660364
-
Therapeutic efficacy of multiple intravenous infusion of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
-
Maini RN, Breedveld FC, Kalden JR, Smolen JS, David D, Macfarlane JD, et al. Therapeutic efficacy of multiple intravenous infusion of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998; 41: 1552-1563
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1552-1563
-
-
Maini, R.N.1
Breedveld, F.C.2
Kalden, J.R.3
Smolen, J.S.4
David, D.5
Macfarlane, J.D.6
-
15
-
-
0033611472
-
A trial of etanercept, a recombinant tumor necrosis factor receptor Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
-
Weinblatt ME, Kremer JM, Bankhurst AD, Bulpitt KJ, Fleischmann RM, Fox RI, Jackson CG, Lange M, Burge DJ. A trial of etanercept, a recombinant tumor necrosis factor receptor Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999; 340: 253-259
-
(1999)
N Engl J Med
, vol.340
, pp. 253-259
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Bankhurst, A.D.3
Bulpitt, K.J.4
Fleischmann, R.M.5
Fox, R.I.6
Jackson, C.G.7
Lange, M.8
Burge, D.J.9
-
16
-
-
0033509841
-
Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis
-
Weinblatt ME, Kremer JM, Coblyn JS, Maier AL, Helfgott SM, Morrell M, Byrne VM, Kaymakcian MV, Strand V. Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 1999; 42: 1322-1328
-
(1999)
Arthritis Rheum
, vol.42
, pp. 1322-1328
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Coblyn, J.S.3
Maier, A.L.4
Helfgott, S.M.5
Morrell, M.6
Byrne, V.M.7
Kaymakcian, M.V.8
Strand, V.9
-
17
-
-
0008341512
-
Adding leflunomide (LEF) to patients with active rheumatoid arthritis (RA) while receiving methotrexate (MTX) improves physical function and health-related quality of life (HRQOL)
-
Furst DE, Luggen ME, Thompson AK, Coleman JO. Adding leflunomide (LEF) to patients with active rheumatoid arthritis (RA) while receiving methotrexate (MTX) improves physical function and health-related quality of life (HRQOL). Arthritis Rheum 2000; 43 (9): A 1664
-
(2000)
Arthritis Rheum
, vol.43
, Issue.9
-
-
Furst, D.E.1
Luggen, M.E.2
Thompson, A.K.3
Coleman, J.O.4
-
18
-
-
0000028735
-
The combination of leflunomide (LEF) and methotrexate (MTX) in patients with rheumatoid arthritis (RA) who are failing on MTX treatment alone: A double-blind placebo (PLC) controlled study
-
Kremer JM, Caldwell JR, Cannon GW, Genovese M, Cush JJ, Bathon J, Coleman JC. The combination of leflunomide (LEF) and methotrexate (MTX) in patients with rheumatoid arthritis (RA) who are failing on MTX treatment alone: A double-blind placebo (PLC) controlled study. Arthritis Rheum 2000; 43 (9): A948
-
(2000)
Arthritis Rheum
, vol.43
, Issue.9
-
-
Kremer, J.M.1
Caldwell, J.R.2
Cannon, G.W.3
Genovese, M.4
Cush, J.J.5
Bathon, J.6
Coleman, J.C.7
-
19
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double blind, randomised, multicentre trial
-
Smolen JS, Kalden JR, Rozman B, Kvien TL, Larsen A, Loew-Friedrich I, Oed C, Rosenburg R. Efficacy and safty of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double blind, randomised, multicentre trial. Lancet 1999; 353: 259-266
-
(1999)
Lancet
, vol.353
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Rozman, B.3
Kvien, T.L.4
Larsen, A.5
Loew-Friedrich, I.6
Oed, C.7
Rosenburg, R.8
-
20
-
-
0031950185
-
Methotrexate in rheumatoid arthritis: An update with focus on mechanisms involved in toxicity
-
VanEde AE, Laan RF, Blom HJ, de Abreu PA, van de Putte LB. Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity. Semin Arthritis Rheum 1998; 27: 277-292
-
(1998)
Semin Arthritis Rheum
, vol.27
, pp. 277-292
-
-
VanEde, A.E.1
Laan, R.F.2
Blom, H.J.3
De Abreu, P.A.4
Van de Putte, L.B.5
-
21
-
-
0032528186
-
Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T Cells
-
Genestier L, Paillot R, Fournel S, Ferraro C, Miossec P, Revillard J-P. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T Cells. J Clin Invest 1998; 102: 322-328
-
(1998)
J Clin Invest
, vol.102
, pp. 322-328
-
-
Genestier, L.1
Paillot, R.2
Fournel, S.3
Ferraro, C.4
Miossec, P.5
Revillard, J.-P.6
-
22
-
-
0031970066
-
Basistherapeutische kombinationstherapie bei chronischer polyarthritis: Ein überblick
-
Menninger H. Basistherapeutische Kombinationstherapie bei chronischer Polyarthritis: Ein Überblick. Z Rheumatol 1998; 57: 25-30
-
(1998)
Z Rheumatol
, vol.57
, pp. 25-30
-
-
Menninger, H.1
-
23
-
-
0025767122
-
Should methotrexate be discontinued before elective orthopedic surgery in patients with rheumatoid arthritis?
-
Bridges SL, Lopez-Mendez A, Han KH, Tracy IC, Alarcon GS. Should methotrexate be discontinued before elective orthopedic surgery in patients with rheumatoid arthritis? J Rheumatol 1991; 18: 984-988
-
(1991)
J Rheumatol
, vol.18
, pp. 984-988
-
-
Bridges, S.L.1
Lopez-Mendez, A.2
Han, K.H.3
Tracy, I.C.4
Alarcon, G.S.5
-
24
-
-
0029981838
-
Postoperative joint infections in rheumatoid arthritis patients on methotrexate therapy
-
Carpenter MT, West SG, Vogelsang SA, Casey Jones DE. Postoperative joint infections in rheumatoid arthritis patients on methotrexate therapy. Orthopedics 1996; 19: 207-210
-
(1996)
Orthopedics
, vol.19
, pp. 207-210
-
-
Carpenter, M.T.1
West, S.G.2
Vogelsang, S.A.3
Casey Jones, D.E.4
-
25
-
-
0026026468
-
Local infection complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate
-
Perhala RS, Wilke WS, Clough JD, Segal AM. Local infection complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate. Arthritis Rheum 1991; 34: 146-152
-
(1991)
Arthritis Rheum
, vol.34
, pp. 146-152
-
-
Perhala, R.S.1
Wilke, W.S.2
Clough, J.D.3
Segal, A.M.4
-
26
-
-
0027303840
-
Infuence of methotrexate on the frequency of post-operative infectious complications in patients with rheumatoid arthritis
-
Sany J, Anaya JM, Canovas F, Combe B, Jorgensen C, Saker S, Thaury MN, Gavroy JP. Infuence of methotrexate on the frequency of post-operative infectious complications in patients with rheumatoid arthritis. J Rheumatol 1993; 20: 1129-1132
-
(1993)
J Rheumatol
, vol.20
, pp. 1129-1132
-
-
Sany, J.1
Anaya, J.M.2
Canovas, F.3
Combe, B.4
Jorgensen, C.5
Saker, S.6
Thaury, M.N.7
Gavroy, J.P.8
-
27
-
-
0030759116
-
Perioperative use of methotrexate - A survey of clinical practice in the UK
-
Steuer A, Keat AC. Perioperative use of methotrexate - a survey of clinical practice in the UK. Br J Rheumatol 1997; 36: 1009-1011
-
(1997)
Br J Rheumatol
, vol.36
, pp. 1009-1011
-
-
Steuer, A.1
Keat, A.C.2
-
28
-
-
0028348017
-
Infection rate and use of antibiotics in patients with rheumatoid arthritis treated with methotrexate
-
Van der Veen MJ, van der Heide A, Kruize AA, Bijlsma JW. Infection rate and use of antibiotics in patients with rheumatoid arthritis treated with methotrexate. Ann Rheum Dis 1994; 53: 224-228
-
(1994)
Ann Rheum Dis
, vol.53
, pp. 224-228
-
-
Van der Veen, M.J.1
Van der Heide, A.2
Kruize, A.A.3
Bijlsma, J.W.4
-
29
-
-
0034537610
-
Safety of low dose methotrexate in elderly patients with rheumatoid arthritis
-
Hirshberg B, Muszkat M, Schlesinger O, Rubinow A. Safety of low dose methotrexate in elderly patients with rheumatoid arthritis. Postgrad Med J 2000; 76: 787-789
-
(2000)
Postgrad Med J
, vol.76
, pp. 787-789
-
-
Hirshberg, B.1
Muszkat, M.2
Schlesinger, O.3
Rubinow, A.4
-
31
-
-
0033947789
-
Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: Findings in a prospektive, randomized, double-blind clinical trial in fifteen patients
-
Kraan MC, de Koster BM, Elferink JG, Post WJ, Breedveld FC, Tak PP. Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospektive, randomized, double-blind clinical trial in fifteen patients. Arthritis Rheum 2000; 43: 1488-1495
-
(2000)
Arthritis Rheum
, vol.43
, pp. 1488-1495
-
-
Kraan, M.C.1
De Koster, B.M.2
Elferink, J.G.3
Post, W.J.4
Breedveld, F.C.5
Tak, P.P.6
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