Multiple organ failure in patients with cardiogenic shock is associated with high plasma levels of interleukin-6

Critical Care Medicine

Volumn 30, Issue 9, 2002, Pages 1987-1994

  Geppert, Alexander ^a   Steiner, Angela ^a   Zorn, Gerlinde ^a   Delle Karth, Georg ^a   Koreny, Maria ^a   Haumer, Markus ^a   Siostrzonek, Peter ^a   Huber, Kurt ^a   Heinz, Gottfried ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cardiogenic shock; Cytokines; Interleukin 6; Multiple organ failure; Sepsis; Septic shock

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ARTICLE; CARDIOGENIC SHOCK; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; FEMALE; HUMAN; IMMUNOPATHOGENESIS; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0036741303     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200209000-00007     Document Type: Article

References (37)

1. Bone RC: Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: What we do and do not know about cytokine regulation. Crit Care Med 1996; 24:163-172
2. Pinsky MR, Matuschak GM: Multiple systems organ failure: Failure of host defense homeostasis. Crit Care Clin 1989; 5:199-220
3. Damas P, Canivet JL, de Groote D, et al: Sepsis and serum cytokine concentrations. Crit Care Med 1997; 25:405-412
4. Casey LC, Balk RA, Bone RC: Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993; 119:771-778
5. Presterl E, Staudinger T, Pettermann M, et al: Cytokine profile and correlation to the APACHE III and MPM II scores in patients with sepsis. Am J Respir Crit Care Med 1997; 156:825-832
6. Pinsky MR, Vincent JL, Deviere J, et al: Serum cytokine levels in human septic shock: Relation to multiple-system organ failure and mortality. Chest 1993; 103:565-575
7. Ueyama M, Maruyama I, Osame M, et al: Marked increase in plasma interleukin-6 in burn patients. J Lab Clin Med 1992; 120: 693-698
8. Hoch RC, Rodriguez R, Manning T, et al: Effects of accidental trauma on cytokine and endotoxin production. Crit Care Med 1993; 21:839-845
9. de Beaux AC, Goldie AS, Ross JA, et al: Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg 1996; 83:349-353
10. Levine B, Kalman J, Mayer L, et al: Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990; 323:236-241
11. Torre-Amione G, Kapadia S, Benedict C, et al: Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 1996; 27:1201-1206
12. Neumann FJ, Ott I, Gawaz M, et al: Cardiac release of cytokines and inflammatory responses in acute myocardial infarction. Circulation 1995; 92:748-755
13. Pudil R, Pidrman V, Krejsek J, et al: Cytokines and adhesion molecules in the course of acute myocardial infarction. Clin Chim Acta 1999; 280:127-134
14. Brunkhorst FM, Clark AL, Forycki ZF, et al: Pyrexia, procalcitonin, immune activation and survival in cardiogenic shock: The potential importance of bacterial translocation. Int J Cardiol 1999; 72:3-10
15. Hasper D, Hummel M, Kleber FX, et al: Systemic inflammation in patients with heart failure. Eur Heart J 1998; 19:761-765
16. de Werra I, Jaccard C, Corradin SB, et al: Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: Comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med 1997; 25:607-613
17. Goldberg RJ, Samad NA, Yarzebski J, et al: Temporal trends in cardiogenic shock complicating acute myocardial infarction. N Engl J Med 1999; 340:1162-1168
18. Goldberg RJ, Gore JM, Alpert JS, et al: Cardiogenic shock after acute myocardial infarction: Incidence and mortality from a community-wide perspective, 1975 to 1988. N Engl J Med 1991; 325:1117-1122
19. Hochman JS, Boland J, Sleeper LA, et al: Current spectrum of cardiogenic shock and effect of early revascularization on mortality: Results of an International Registry SHOCK Registry Investigators. Circulation 1995; 91: 873-881
20. Califf RM, Bengtson JR: Cardiogenic shock. N Engl J Med 1994; 330:1724-1730
21. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis: The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
22. Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis- Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710
23. Plenz G, Song ZF, Reichenberg S, et al: Left-ventricular expression of interleukin-6 messenger-RNA higher in idiopathic dilated than in ischemic cardiomyopathy. Thorac Cardiovasc Surg 1998; 46:213-216
24. Yamauchi-Takihara K, Ihara Y, Ogata A, et al: Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation 1995; 91:1520-1524
25. Liao J, Keiser JA, Scales WE, et al: Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver. Am J Physiol 1995; 268:R896-R901
26. Yan SF, Tritto I, Pinsky D, et al: Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6. J Biol Chem 1995; 270:11463-11471
27. Koga S, Ogawa S, Kuwabara K, et al: Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes. J Clin Invest 1992; 90:1007-1015
28. Metinko AP, Kunkel SL, Standiford TJ, et al: Anoxia-hyperoxia induces monocyte-derived interleukin-8. J Clin Invest 1992; 90:791-798
29. Karakurum M, Shreeniwas R, Chen J, et al: Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J Clin Invest 1994; 93:1564-1570
30. Hasdai D, Holmes DR Jr, Califf RM, et al: Cardiogenic shock complicating acute myocardial infarction: Predictors of death. GUSTO Investigators. Global Utilization of Streptokinase and Tissue-Plasminogen Activator for Occluded Coronary Arteries. Am Heart J 1999; 138:21-31
31. Hochman JS, Sleeper LA, Webb JG, et al: Early revascularization in acute myocardial infarction complicated by cardiogenic shock: SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. N Engl J Med 1999; 341:625-634
32. Janssens U, Graf C, Graf J, et al: Evaluation of the SOFA score: A single-center experience of a medical intensive care unit in 303 consecutive patients with predominantly cardiovascular disorders. Sequential Organ Failure Assessment. Intensive Care Med 2000; 26:1037-1045
33. Ridruejo E, Laurini J, Cingolani O: Fulminant hepatic failure: Atypical form of cardiac failure presentation. Medicina 2000; 60:491-494
34. Vilas-Boas F, Monachini MC, Farias A, et al: Acute liver failure secondary to cardiogenic shock in patients with congestive heart failure. Arq Bras Cardiol 1994; 62:427-430
35. Finkel MS, Oddis CV, Jacob TD, et al: Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992; 257:387-389
36. Meldrum DR, Donnahoo KK: Role of TNF in mediating renal insufficiency following cardiac surgery: Evidence of a postbypass cardiorenal syndrome. J Surg Res 1999; 85:185-199
37. Bertges DJ, Fink MP, Delude RL: Hypoxic signal transduction in critical illness. Crit Care Med 2000; 28:N78-N86