Exhaled nitric oxide does not reflect the severity of acute lung injury: An experimental study in a rat model of extracorporeal circulation

Critical Care Medicine

Volumn 30, Issue 9, 2002, Pages 2096-2102

  Zegdi, Rachid ^a   Fabre, Olivier ^a   Cambillau, Michèle ^a   Détruit, Hélène ^a   Fornès, Paul ^a   Rajnoch, Charissa ^a   Shen, Ming ^a   Hervé, Philippe ^a   Carpentier, Alain ^a   Fabiani, Jean Noël ^a  

^a HÔPITAL BROUSSAIS   (France)

Author keywords

Acute lung injury; Breath test; Chemiluminescence analyzer; Critical care; Extracorporeal circulation; Nitric oxide

Indexed keywords

HEME OXYGENASE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CHEMOLUMINESCENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DISEASE SEVERITY; ENZYME ACTIVITY; EXHALATION; EXPERIMENTAL MODEL; EXTRACORPOREAL CIRCULATION; LUNG FLUID; LUNG INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0036741283     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200209000-00024     Document Type: Article

References (41)

1. Fowler AA, Hamman RF, Good JT, et al: Adult respiratory distress syndrome: Risk with common predispositions. Ann Intern Med 1983; 98:593-597
2. Christenson JT, Aeberhard J-M, Badel P, et al: Adult respiratory distress syndrome after cardiac surgery. Cardiovasc Surg 1996; 4:15-21
3. Asimakopoulos G, Taylor KM, Smith PL, et al: Prevalence of acute respiratory distress syndrome after cardiac surgery. J Thorac Cardiovasc Surg 1999; 117:620-621
4. Ratliff NB, Young WG, Hackel DB, et al: Pulmonary injury secondary to extracorporeal circulation. An ultrastructural study. J Thorac Cardiovasc Surg 1973; 65:425-432
5. Anyanwu E, Dittrich H, Gieseking R, et al: Ultrastructural changes in the human lung following cardiopulmonary bypass. Basic Res Cardiol 1982; 77:309-322
6. Stewart TE, Valenza F, Ribeiro SP, et al: Increased nitric oxide in exhaled gas as an early marker of lung inflammation in a model of sepsis. Am J Respir Crit Care Med 1995; 151:713-718
7. Tassiopoulos AK, Carlin RE, Gao Y, et al: Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities. J Vasc Surg 1997; 26:647-656
8. Convention européenne sur la protection des animaux vertébrés utilisés à des fins expérimentales ou à d'autres fins scientifiques. J Officiel Communautés Européennes 1999; L222-L237
9. Deleted in proof
10. Mullane KM, Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration in ischemic myocardium. J Pharmacol Methods 1985; 14:157-167
11. Tenhunen R, Marver HS, Schmid R: The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Biochemistry 1968; 61:748-755
12. Maines MD: Carbon monoxide and nitric oxide homology: Differential modulation of heme oxygenases in brain and detection of protein and activity. Methods Enzymol 1996; 268:473-488
13. Turnage RH, Kadesky KM, Bartula L, et al: Intestinal reperfusion up-regulates inducible nitric oxide synthase activity within the lung. Surgery 1995; 118:288-293
14. Arkovitz MS, Wispe JR, Garcia VF, et al: Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia. J Pediatr Surg 1996; 31:1009-1015
15. Gillinov AM, DeValeria PA, Winkelstein JA, et al: Complement inhibition with soluble complement receptor type 1 in cardiopulmonary bypass. Ann Thorac Surg 1993; 55:619-624
16. Dreyer WJ, Michael LH, Millman EE, et al: Neutrophil sequestration and pulmonary dysfunction in a canine model of open heart surgery with cardiopulmonary bypass. Evidence for a CD18-dependent mechanism. Circulation 1995; 92:2276-2283
17. Ballaux PK, Gourlay T, Ratnatunga CP, et al: A review of cardiopulmonary bypass models for rats. Perfusion 1999; 14:411-417
18. Fabre O, Zegdi R, Vincentelli A, et al: A recovery model of partial cardiopulmonary bypass in the rat. Perfusion 2001; 16:215-220
19. Maines MD: The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37:517-554
20. Choi AMK, Alam J: Heme oxygenase 1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 1996; 15:9-19
21. Otterbein LE, Mantell LL, Choi AMK: Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol 1999; 276:L688-L694
22. Otterbein LE, Kolls JK, Mantell LL, et al: Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J Clin Invest 1999; 103:1047-1054
23. Kharitonov SA, Yates D, Robbins RA, et al: Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343:133-135
24. Silkoff PE, Caramori M, Tremblay L, et al: Exhaled nitric oxide in human lung transplantation: A noninvasive marker of acute rejection. Am J Respir Crit Care Med 1998; 157:1822-1828
25. Massaro AF, Gaston B, Kita D, et al: Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995; 152:800-803
26. Gabbay E, Walters EH, Orsida B, et al: In stable lung transplant recipients, exhaled nitric oxide levels positively correlate with airway neutrophilia and bronchial epithelial iNOS. Am J Respir Crit Care Med 1999; 160:2093-2099
27. Jatakanon A, Lim S, Kharitonov SA, et al: Correlation between exhaled nitric oxide, sputum eosinophils, and metacholine responsiveness in patients with mild asthma. Thorax 1998; 53:91-95
28. Kobzik L, Bredt DS, Lowenstein CJ, et al: Nitric oxide synthase in human and rat lung: Immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 1993; 9:371-377
29. Albertine KH, Wang ZM, Michael JR: Expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and endothelin-1 in lungs of subjects who died with ARDS. Chest 1999; 116:101S-102S
30. Brett SJ, Evans TW: Measurement of endogenous nitric oxide in the lungs of patients with the acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 157:993-997
31. Cucchiaro G, Tatum AH, Brown MC, et al: Inducible nitric oxide synthase in the lung and exhaled nitric oxide after hyperoxia. Am J Physiol 1999; 277:L636-L644
32. Carlin RE, Ferrario L, Boyd JT, et al: Determinants of nitric oxide in exhaled gas in the isolated rabbit lung. Am J Respir Crit Care Med 1997; 155:922-927
33. Cremona G, Higenbottam T, Takao M, et al: Exhaled nitric oxide in isolated pig lungs. J Appl Physiol 1995; 78:59-63
34. Morris SM, Billiar TR: New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol 1994; 266:E829-E839
35. Que LG, Kantrow SP, Jenkinson CP, et al: Induction of arginase isoforms in the lung during hyperoxia. Am J Physiol 1998; 275:L96-L102
36. Hunt JF, Fang K, Malik R, et al: Endogenous airway acidification: Implications for asthma pathophysiology. Am J Respir Crit Care Med 2000; 161:694-699
37. Gaston B, Drazen JM, Loscalzo J, et al: The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994; 149:538-551
38. Liaudet L, Soriano FG, Szabo C: Biology of nitric oxide signaling. Crit Care Med 2000; 28(Suppl):N37-N52
39. Pearl JM, Nelson DP, Wellmann SA, et al: Acute hypoxia and reoxygenation impairs exhaled nitric oxide release and pulmonary mechanics. J Thorac Cardiovasc Surg 2000; 119:931-938
40. Brett SJ, Quilan GJ, Mitchell J, et al: Production of nitric oxide during surgery involving cardiopulmonary bypass. Crit Care Med 1998; 26:272-278
41. Beghetti M, Silkoff PE, Caramori M, et al: Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass-induced injury. Ann Thorac Surg 1998; 66:532-534