Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells

Haematologica

Volumn 87, Issue 9, 2002, Pages 903-907

  Sanz, Cristina ^a   Horita, Machiko ^a   Fernandez Luna, José Luis ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

DREAM; Fas; Hrk; STI571

Indexed keywords

BCR ABL PROTEIN; CALSENILIN; CASPASE 3; FAS ANTIBODY; FAS ANTIGEN; GENE PRODUCT; HRK PROTEIN; IMATINIB; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA BINDING; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE INACTIVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LEUKEMIA CELL LINE; MULTIGENE FAMILY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN INDUCTION; TRANSCRIPTION REGULATION;

ANTIGENS, CD95; APOPTOSIS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CASPASE 3; CASPASES; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; JURKAT CELLS; K562 CELLS; KV CHANNEL-INTERACTING PROTEINS; LEUKEMIA; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 0036739531     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281:1312-6.
2. Nunez G, Benedict MA, Hu Y, Inohara N. Caspases: the proteases of the apoptotic pathway. Oncogene 1998; 17:3237-45.
3. Huang DC, Strasser A. BH3-only proteins-essential initiators of apoptotic cell death. Cell 2000; 103:839-42.
4. Korsmeyer SJ. BCL-2 gene family and the regulation of programmed cell death. Cancer Res 1999; 59 Suppl 7: 1693s-700s.
5. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998; 281:1322-6.
6. Sanz C, Benito A, Inohara N, Ekhterae D, Nunez G, Fernandez-Luna JL. Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells. Blood 2000; 95:2742-7.
7. +-regulated transcriptional repressor. Nature 1999; 398:80-4.
8. Sanz C, Mellstrom B, Link WA, Naranjo JR, Fernandez-Luna JL. Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells. EMBO J 2001; 20: 2286-92.
9. Friesen C, Fulda S, Debatin KM. Cytotoxic drugs and the CD95 pathway. Leukemia 1999;13:1854-8.
10. Findley HW, Zhou M. The clinical significance of Fas expression in leukemia: questions and controversies. Leukemia 1999; 13:147-9.
11. Kantarjian H, Sawyers C, Hochhaus A, Guilhot F, Schiffer C, Gambacorti-Passerini C, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. The International STI571 CML Study Group. N Engl J Med 2002; 346:645-52.
12. L. J Exp Med 2000; 191:977-84.
13. Droin N, Bichat F, Rebe C, Wotawa A, Sordet O, Hammann A, et al. Involvement of caspase-2 long isoform in Fasmediated cell death of human leukemic cells. Blood 2001; 97:1835-44.
14. Micheau O, Solary E, Hammann A, Martin F, Dimanche-Boitrel MT. Sensitization of cancer cells treated with cytotoxic drugs to fas-mediated cytotoxicity. J Natl Cancer Inst 1997; 89:783-9.
15. Scaffidi C, Schmitz I, Zha J, Korsmeyer SJ, Krammer PH, Peter ME. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem 1999; 274:22532-8.
16. Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, et al. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem 2001; 276:19197-204.
17. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15:2922-33.
18. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94:481-90.
19. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94:491-501.