Decreased Insulin Receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: Effects of serine kinase inhibitors and IR activators

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 9, 2002, Pages 4088-4093

  Li, Ming ^a,b,c,d,e   Youngren, Jack F ^a,b,c,d,e   Dunaif, Andrea ^a,b,c,d,e   Goldfine, Ira D ^a,b,c,d,e   Maddux, Betty A ^a,b,c,d,e   Zhang, Bei B ^a,b,c,d,e   Evans, Joseph L ^a,b,c,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d Telik Inc   (United States)

^e Medical Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; ENZYME ACTIVATOR; ENZYME INHIBITOR; INSULIN; INSULIN RECEPTOR; MERCK L7; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN SERINE KINASE; TLK 16998; UNCLASSIFIED DRUG;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; AUTOPHOSPHORYLATION; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN BIOPSY;

ADOLESCENT; ADULT; AZO COMPOUNDS; CELL LINE; CELLS, CULTURED; ENZYME INHIBITORS; FEMALE; FIBROBLASTS; HUMANS; INSULIN RESISTANCE; KINETICS; NAPHTHALENES; PHOSPHORYLATION; POLYCYSTIC OVARY SYNDROME; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, INSULIN; REFERENCE VALUES;

EID: 0036738335     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020363     Document Type: Article

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