Inhibition of human topoisomerase IIα by fluoroquinolones and ultraviolet A irradiation

Toxicological Sciences

Volumn 69, Issue 1, 2002, Pages 16-22

  Perrone, Carmen E ^a   Takahashi, Kyoko C ^b   Williams, Gary M ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b MOUNT HOLYOKE COLLEGE   (United States)

Author keywords

Fluoroquinolones; Human topoisomerase II ; Photogenotoxicity

Indexed keywords

8 CHLORO 1 CYCLOPROPYL 7 (2,8 DIAZABICYCLO[4.3.0]NON 8 YL) 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CIPROFLOXACIN; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; LOMEFLOXACIN; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REACTIVE OXYGEN METABOLITE;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; MUTAGENICITY; PHOTOCHEMISTRY; RADIATION EXPOSURE; ULTRAVIOLET A RADIATION;

ANTIGENS, NEOPLASM; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FLUOROQUINOLONES; HUMANS; MUTAGENS; PHOTOCHEMISTRY; PLASMIDS; ULTRAVIOLET RAYS;

VERTEBRATA;

EID: 0036737089     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.1.16     Document Type: Article

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