CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast

Molecular Carcinogenesis

Volumn 35, Issue 1, 2002, Pages 6-12

  Mercapide, Javier ^a   Zhang, Shi Yu ^b   Fan, Xing ^a   Furió Bacete, Vicente ^c   Schneider, José ^d,e   De La Osa, Íñigo López ^c   Patchefsky, Arthur S ^b   Klein Szanto, Andrés J P ^b   Castresana, Javier S ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b FOX CHASE CANCER CENTER   (United States)

^c HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^d UNIVERSIDAD REY JUAN CARLOS   (Spain)

^e Centro de Patologia de la Mama   (Spain)

Author keywords

Breast cancer; CCND1; ERBB2; Genetics; Invasive lobular carcinoma; PTEN

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GENE PRODUCT; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GRADING; CCND1 GENE; DEREGULATION; ERBB2 GENE; GENE; GENE AMPLIFICATION; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; ONCOGENE C ERB; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PTEN GENE; SINGLE STRAND CONFORMATION POLYMORPHISM;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; CELL CYCLE PROTEINS; CYCLIN D1; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; KI-67 ANTIGEN; NEOPLASM INVASIVENESS; PHOSPHORIC MONOESTER HYDROLASES; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PTEN PHOSPHOHYDROLASE; RECEPTOR, ERBB-2; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0036733593     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10069     Document Type: Article

References (27)

1. Invasive lobular carcinoma of the breast: Incidence and variants
2. Somatic genetic changes in human breast cancer
3. Genetic alterations in breast cancer
4. E2F-1: A proliferative marker of breast neoplasia
5. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
6. PTEN tumor suppressor is linked to the cell cycle control through the retinoblastoma protein
7. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
8. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
9. Identification of a novel PTEN mutation (L139X) in a patient with Cowden disease and Sjogren's syndrome
10. Amplification and over-expression of cyclin D1 in breast cancer detected by immunohistochemical staining
11. Cyclin D1 (PRAD1) protein expression in breast cancer: Approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene
12. Cyclin-D1 gene amplification and protein expression in benign breast disease and breast carcinoma
13. Correlation of c-erbB2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading
14. ERBB2 amplification in breast cancer with a high rate of proliferation
15. Int-2 and c-erbB-2 gene amplification detected in 70 frozen human breast carcinomas by quantitative polymerase chain reaction
16. Detection of mutations in gynecologic tumors by means of a simple, nonradioactive minigel method of PCR-SSCP analysis
17. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers
18. Cyclin D1 and retinoblastoma gene expression in human breast carcinoma: Correlation with tumor proliferation and oestrogen receptor status
19. A comparison of cell cycle markers in well-differentiated lobular and ductal carcinomas
20. Immunohistochemistry of cyclin D1 in human breast cancer
21. Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value
22. Cyclin D1 gene amplification and overexpression are present in ductal carcinoma in situ of the breast
23. Cyclin E, a potential prognostic marker for breast cancer
24. A study of the PTEN/MMAC1 gene in 136 breast cancer families
25. Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer
26. ERBB2 oncogene in human breast cancer and its clinical significance
27. Comparative allelotype of in situ and invasive human breast cancer: High frequency of microsatellite instability in lobular breast carcinomas