int-2 and c-erbB-2 gene amplification detected in 70 frozen human breast carcinomas by quantitative polymerase chain reaction

Anticancer Research

Volumn 17, Issue 4 B, 1997, Pages 3133-3136

  An, H X ^a   Niederacher, D ^a,b   Dominik, S I ^a   Kuschel, B ^a   Yan, H ^a   Dall, P ^a   Schnurch H G ^a   Bender, H G ^a   Beckmann, M W ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Breast cancer; c erbB 2; Gene amplification; Int 2; PCR

Indexed keywords

DNA; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

BREAST CARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; DNA DETERMINATION; FLUORESCENCE ANALYSIS; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; ONCOGENE C ERB; ONCOGENE NEU; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; TUMOR GROWTH;

EID: 0030801179     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (9)

1. El-Ashry D and Lippman ME: Molecular Biology of breast carcinoma. World J Surg 18: 12-20, 1994.
2. Berns, EMJJ, Klijn JGM, van Staveren IL, Portengen H, Noordegraaf E and Foekens JA: Prevalence of amplification of the oncogenes c-myc, her2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors. Eur J Cancer 28: 697-700, 1992.
3. Hruza C, Dobianer K, Beck A, Czerwenka K, Hanak H, Klein M, Leodolter S, Michael M, Müllauer-Ertl S, Preiser J, ROsen A, Salzer H, Sevelda P and Spona J: Her-2 and int-2 amplification estimated by quantitative PCR in paraffinembedded ovarian cancer tissues samples. Eur J Cancer 29A: 1593-1597, 1993.
4. Beckmann MW, Tutschek B, Krüger KH, Niederacher D, Risse BC, Ruppert C, Schnürch H-G and Bender HG: Biochemical and immunohistochemical detection of the epidermal growth factor receptor (EGF-R) in breast tumour specimens. Int J Oncol 3: 389-397, 1993.
5. Shibata D: Extraction of DNA from paraffin-embedded tissue for analysis by polymerase chain reaction: new tricks from an old friend. Hum Pathol 25: 561-563, 1994.
6. An H-X, Niederacher D, Beckmann MW, Göhring U-J, Scharl A, Picard F, van Roeyen C, Schnürch H-G and Bender HG: ERBB2 amplification detected by fluorescent differential polymerase chain reaction in paraffin-embedded breast carcinama tissues. Int J Cancer 64: 291-297, 1995.
7. Hubbard AL, Doris CP, Thompson AM, Chetty U and Anderson TJ: Critical determination of the frequency of c-erbB-2 amplification in breast cancer. Br J Cancer 70: 434-439, 1994.
8. Niederacher D, An H-X, Picard F, Rossbach T and Beckmann MW: Rapid detection of genetic alteration on chromosome 17q21 in sporadic human breast carcinoma by quantitative PCR and microsatellite analysis using fluorescent DNA technology. P Am Assoc Cane Res 36: 545, 1995.
9. Muss HB, Thor AD, Berry DA, Kute T, Liu ET, Koerner F, Cirrincione CT, Budman DR, Wood WC and Barcos M: c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. N Engl J Med 330: 11260-12667, 1993.