Induction of permanent mixed chimerism and skin allograft tolerance across fully MHC-mismatched barriers by the additional myelosuppressive treatments in mice primed with allogeneic spleen cells followed by cyclophosphamide

Journal of Immunology

Volumn 165, Issue 1, 2000, Pages 34-41

  Tomita, Yukihiro ^a   Yoshikawa, Masahiro ^b   Zhang, Qi Wei ^a   Shimizu, Ichiro ^a   Okano, Shinji ^b   Iwai, Toshiro ^a   Yasui, Hisataka ^a   Nomoto, Kikuo ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BUSULFAN; CYCLOPHOSPHAMIDE;

ALLOGENEIC RESTRICTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CHIMERA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLOGRAFT; SPLEEN CELL;

EID: 0034234606     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.1.34     Document Type: Article

References (44)

1. Schwartz, R., and W. Dameshek. 1959. Drug-induced Immunological tolerance. Nature 183:1682.
2. Meeker, W. R., R. M. Condie, R. A. Good, and R. L. Varco. 1960. Alteration of homograft response by antimetabolites. Ann. NY Acad. Sci. 87:203
3. Calne, R.Y. 1960. The rejection of renal homografts: Inhibition in dogs by 6-mercaptopurine. Lancet 1:417
4. Uphoff, D.E. 1961. Drug-induced immunological "tolerance" for homo-transplantation. Transplant. Bull. 28:110.
5. McLaren, A. 1961. Induction of tolerance to skin homografts in adult mice treated with 6-mercaptopurine. Transplant. Bull. 28:479.
6. Berenbaum, M. C. 1963. Prolongation of homograft survival in mice with single doses of cyclophosphamide. Nature 200:84.
7. Santos, G. W., and A. H. Owens. 1965. A comparison of the effects of selected cytotoxic agents on allogeneic skin graft survival in rat. Bull. Johns Hopkins Hosp. 116:327.
8. Floersheim, G. L. 1972. Curative potencies against amanitin poisoning by cytochrome c. Science 177:808.
9. Aisenberg, A. C. 1967. Studies on cyclophosphamide-induced tolerance to sheep erythrocytes. J. Exp. Med. 125:833.
10. Nirmul, G., C. Severin, and R. N. Taub. 1971. Cyclophosphamide-induced immunologic tolerance to skin homografts. Surg. Forum 22:287.
11. Marquet, R., and G. Heystek. 1975. The induction and abolition of specific immunosuppression of heart allografts in rats by use of donor blood and cyclophosphamide. J. Immunol. 115:405.
12. Kelly, W. D., M. F. McKneally, F. Oliveras, C. Martinez, and R. A. Good. 1966. Cell-free antigenic material employed to produce tolerance to skin grafts: Tissue sources, preservation, dose requirements and the effects of combined use with azathioprine and sublethal irradiation. Ann. NY Acad. Sci.129:210.
13. Shin, T., H. Mayumi, K. Himeno, H. Sanui, and K. Nomoto. 1984. Drug-induced tolerance to allografts in mice. I. Difference between tumor and skin grafts. Transplantation 37:580.
14. Mayumi, H., T. Shin, K. Himeno, and K. Nomoto. 1985. Drug-induced tolerance to allografts in mice. II. Tolerance to tumor allografts of larger doses associated with rejection of skin allografts and tumor allografts of small doses. Immunobiology 169:147.
15. Mayumi, H., K. Himeno, T. Shin, and K. Nomoto. 1985. Drug-induced tolerance to allografts in mice. IV. Mechanisms and kinetics of cyclophosphamide-induced tolerance. Transplantation 39:209.
16. Mayumi, H., K. Himeno, K. Tanaka, N. Tokuda, J. Fan, and K. Nomoto. 1986. Drug-induced tolerance to allografts in mice. XII. The relationship between tolerance, chimerism, and graft-versus-host disease. Transplantation 42:417.
17. Tomita, Y., H. Mayumi, M. Eto, and K. Nomoto. 1990. Importance of suppressor T cells in cyclophosphamide-induced tolerance to the non-H-2-encoded alloantigens: Is mixed chimerism really required in maintaining a skin allograft tolerance? J. Immunol. 144:463.
18. + T cells in cyclophosphamide-induced tolerance to H-2-compatible, Mls-disparate antigens. J. Exp. Med. 171:97.
19. Tomita, Y., Y. Nishimura, N. Harada, M. Eto, K. Ayukawa, Y. Yoshikai, and K. Nomoto. 1990. Evidence for involvement of clonal anergy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion. J. Immunol. 145:4026.
20. Eto, M., H. Mayumi, Y. Tomita, Y. Yoshikai, Y. Nishimura, and K. Nomoto. 1990. Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion. J. Immunol. 145:1303.
21. Zhang, Q. W., H. Mayumi, M. Umesue, Y. Tomita, K. Nomoto, and H. Yasui. 1997. Fractionated dosing of cyclophosphamide for establishing long-lasting skin allograft survival, stable mixed chimerism, and intrathymic clonal deletion in mice primed with allogeneic spleen cells. Transplantation 63:1667.
22. Maeda, T., M. Eto, Y. Nishimura, K. Nomoto, Y. Y. Kong, and K. Nomoto. 1993. Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice. J. Immunol. 150:753.
23. Yoshikawa, M., Y. Tomita, T. Uchida, Q-W. Zhang, and K. Nomoto. 1999. Lack of pluripotent stem cell engraftment in cyclophosphamide-induced tolerance. Transplant. Proc. 31:898.
24. Yoshikawa, M., Y. Tomita, T. Uchida, Q-W. Zhang, I. Shimizu, and K. Nomoto. 1999. 200 mg/kg cyclophosphamide lacks ability to induce pluripotent stem cell engraftment in mice. Transplant. Proc. 31:1939.
25. Yoshikawa, M., Y. Tomita, T. Uchida, Q-W. Zhang, and K. Nomoto. 2000. Inability of cyclophosphamide-induced tolerance to permit engraftment of pluripotent stem cell contained in moderate number of syngeneic bone marrow cells. Immunobiology 201:552.
26. Tomita, Y., A. Khan, and M. Sykes. 1994. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen. J. Immunol. 153: 1087.
27. Kurlander, R. J., D. M. Ellison, and J. Hall. 1984. The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes. J. Immunol. 133:855.
28. Storb, R., D. Buckner, L. A. Dillingham, and E. D. Thomas. 1970. Cyclophosphamide regimens in rhesus monkeys with and without marrow infusion. Cancer Res. 30:2195.
29. Ria, F., G. Penna, and L. Adorini. 1998. Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells. Eur. J. Immunol. 28:2003.
30. Sykes, M., and D. H. Sachs. 1988. Mixed allogeneic chimerism as an approach to transplantation tolerance. Immunol. Today 9:23.
31. Slavin, S., S. Strober, Z. Fucks, and H. S. Kaplan. 1977. Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: Long-term survival of allogeneic bone marrow and skin grafts. J. Exp. Med. 169:493.
32. Ildstad, S.T., and D. H. Sachs. 1984. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 307:168.
33. Cobbold, S.P., G. Martin, S. Qin, and H. Waldmann. 1986. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 323:164.
34. Sharabi, Y., and D. H. Sachs. 1989. Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen. J. Exp. Med. 169:493.
35. Wekerle, T., M. H. Sayegh, J. Hill, Y. Zhao, A. Chandraker, K. G. Swenson, G. Zhao, and M. Sykes M. 1998. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J. Exp. Med. 187:2037.
36. Leong, L. Y., S. Qin, S. P. Cobbold, and H. Waldmann. 1992. Classical transplantation tolerance in the adult: The interaction between myeloablation and immunosuppression. Eur. J. Immunol. 22:2825.
37. Sykes, M., G. L. Szot, K. A. Swenson, and D. A. Pearson. 1997. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nature Med. 3:783.
38. Tomita, Y., D. H. Sachs, and M. Sykes. 1994. Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. Blood 83:939.
39. Miller, R. G. 1980. An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature 287:544.
40. Muraoka, S., and R. G. Miller. 1980. Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens. J. Exp. Med. 152:54.
41. Maier, T., J. H. Holda, and H. N. Claman. 1986. Natural suppressor (NS) cells: Member of the LGL regulatory family. Immunol. Today 7:312.
42. Qin, S., S. P. Cobbold, R. Benjamin, and H. Waldmann. 1989. Induction of classical transplantation tolerance in the adult. J. Exp. Med. 169:779.
43. Tomita, Y., D. H. Sachs, A. Khan, and M. Sykes. 1996. Additional mAb injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3 Gy whole body irradiation. Transplantation 61:469.
44. Tomita, Y., A. Khan, and M. Sykes. 1996. Mechanisms by which additional monoclonal antibody injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3 Gy whole body irradiation. Transplantation 61:477.