TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism

Journal of Immunology

Volumn 169, Issue 5, 2002, Pages 2451-2460

  Harlin, Helena ^a   Podack, Eckhard ^a   Boothby, Mark ^a   Alegre, Maria Luisa ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD28 ANTIGEN; CD30 ANTIGEN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; DOSE RESPONSE; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE ACTIVATION; TRANSGENE;

EID: 0036721704     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.5.2451     Document Type: Article

References (40)

1. CD28/B7 system of T cell costimulation
2. Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines
3. Cross-linking of CD30 on activated human Th clones enhances their cytokine production and downregulates the CD30 expression
4. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40
5. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection
6. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses
7. Structure and expression of murine CD30 and its role in cytokine production
8. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
9. Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells
10. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice
11. CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2-sensitive pathway
12. The TNF receptor family member CD30 is not essential for negative selection
13. Apoptosis mediated by the TNF-related cytokine and receptor families
14. TNF receptor associated factors in cytokine signaling
15. Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily
16. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFKB activation
17. CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins
18. Induction of nuclear factor κB by the CD30 receptor is mediated by TRAF1 and TRAF2
19. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival
20. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-KB
21. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
22. ras
23. CD30 ligation induces nuclear factor-κB activation in human T cell lines
24. Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response
25. CD28 is not required for c-Jun N-terminal kinase activation in T cells
26. + T cells in vivo by IL-15
27. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production
28. CD28 signaling via VAV/SLP-76 adaptors: Regulation of cytokine transcription independent of TCR ligation
29. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor κB
30. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand
31. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
32. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
33. Differences between IL-4Rα-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
34. Requirement for IL-13 independently of IL-4 in experimental asthma
35. Interleukin-13: Central mediator of allergic asthma
36. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells
37. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
38. Cutting edge: Spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice
39. Suppression of an IL-13 autocrine growth loop in a human Hodgkin/Reed-Sternberg tumor cell line by a novel IL-13 antagonist
40. Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease