DNA-targeted 2-nitroimidazoles: Studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation

Radiation Research

Volumn 158, Issue 3, 2002, Pages 302-310

  Buchko, Garry W ^a   Weinfeld, Michael ^a  

^a CROSS CANCER INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 NITROIMIDAZOLE DERIVATIVE; 5 [3 (2 NITRO 1 IMIDAZOLYL)BUTYL]PHENANTHRIDINIUM BROMIDE; 5 [3 (2 NITRO 1 IMIDAZOLYL)PROPYL]PHENANTHRIDINIUM BROMIDE; DNA; MISONIDAZOLE; NITROIMIDAZOLE DERIVATIVE; PHENANTHRIDINE DERIVATIVE; PHOSPHORUS 32; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ARTICLE; AUTORADIOGRAPHY; CATTLE; CHEMICAL STRUCTURE; DNA DAMAGE; GENE TARGETING; HISTOGRAM; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIZATION;

EID: 0036721345     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2002)158[0302:DTNSOT]2.0.CO;2     Document Type: Article

References (45)

1. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
2. The influence of oxygen on the radiosensitivity of mammalian tissues
3. Hypoxia in tumors: A paradigm for the approach to biochemical and physiological heterogeneity
4. Electron-affinic sensitization. I. A structural basis for chemical radiosensitizers in bacteria
5. Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles
6. Radiation and high-dose metronidazole in supratentorial glioblastomas
7. Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
8. Gamma radiolysis of thymine in oxygen-free aqueous solution in the presence of electron affinic radiosensitizers: Identification of stable products
9. Radiosensitizers as probes of DNA damage and cell killing
10. Influence of nitrogen, oxygen, and nitroimidazole radiosensitizers on DNA damage induced by ionizing radiation
11. Sites and structure of γ radiation-induced DNA strand breaks
12. γray induced deoxyribonucleic acid strand breaks. 3′ glycolate termini
13. Base sequence damage in DNA from X-irradiated monkey CV-1 cells
14. Enzyme action at 3′ termini of ionizing radiation-induced DNA strand breaks
15. 32P-postlabeling detection of radiation-induced DNA damage: Identification and estimation of thymine glycols and phosphoglycolate termini
16. Misonidazole-platinum complexes as potential radiosensitizers
17. Radiation sensitization and chemopotentiation: RSU-1069, a compound more efficient than misonidazole in vitro and in vivo
18. Targeting radiosensitizers to DNA by attachment of an intercalating group: Nitroimidazole-linked phenanthridines
19. DNA-targeted 2-nitroimidazoles: In vitro and in vivo studies
20. Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions
21. 32P-postlabelling assay for apurinic sites in DNA
22. Postlabelling methods for the detection of apurinic sites and radiation-induced DNA damage
23. Influence of anoxic sensitizers on the radiation damage in biologically active DNA in aqueous solution
24. Radiation-induced hydroxylation of thymine promoted by electron-affinic compounds
25. Effect of ethidium bromide intercalation on DNA radiosensitivity
26. Neocarzinostatin-induced hydrogen atom abstraction from C-4′ and C-5′ of the T residue at a d(GT) step in oligonucleotides: Shuttling between deoxyribose attack sites based on isotope selection effects
27. Radiosensitizing and cytotoxic properties of DNA targeted phenanthridine-linked nitroheterocycles of varying electronic affinities
28. The time interval after pulsed irradiation within which injury to bacteria can be modified by dissolved oxygen
29. Irradiation of Serratia marcescens by single and double pulses of high-intensity electrons: Oxygen kinetics and lifetime of oxygen-sensitive species
30. Time-resolved oxygen effects in irradiated bacteria and mammalian cells: A rapid-mix study
31. Radiosensitization of mammalian cells in vitro by nitroacridines
32. Electron transfer and radical-addition in the radiosensitization and chemotherapy of hypoxic cells
33. DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3′-phosphoglycolate termini
34. Dual action of tirapazamine in the induction of DNA strand breaks
35. Formation of modified cleavage termini from the reaction of chromium (V) with DNA
36. Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system
37. Construction of a vector containing a site-specific DNA double-strand break with 3′-phosphoglycolate termini and analysis of the products of end-joining in CV-1 cells
38. 3′-blocking damage of DNA as a mutagenic lesion caused by hydrogen peroxide in Escherichia coli
39. 3′-phosphodiesterase and 3′→5′ exonuclease activities of yeast Apn 2 protein and requirement of these activities for repair of oxidative DNA damage
40. Repair of oxidative damage to DNA: Enzymology and biology
41. Further purification and characterization of the DNA 3′-phosphatase from rat-liver chromatin which is also a polynucleotide 5′-hydroxyl kinase
42. Purification and substrate specificity of polydeoxyribonucleotide kinases isolated from calf thymus and rat liver
43. 3′-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends
44. Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3′-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation