Proapoptotic protein PACT is expressed at high levels in colonic epithelial cells in mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 3 46-3, 2002, Pages

  Gupta, Vishal ^a   Patel, Rekha C ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Apoptosis; Eukaryotic protein synthesis initiation factor 2 ; Interferon; Protein kinase; RNA activated protein kinase

Indexed keywords

ENZYME ACTIVATOR; INITIATION FACTOR 2; INTERFERON; PROTEIN KINASE; PROTEIN PACT; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; COLON MUCOSA; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM;

EID: 0036720910     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00498.2001     Document Type: Article

References (39)

1. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling
2. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation
3. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
4. Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression
5. Modulation of epithelial cell adhesion in gastrointestinal homeostasis
6. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
7. The double stranded RNA-activated protein kinase induced by interferon: dsRNA-PK
8. The double-stranded RNA-dependent protein kinase is also activated by heparin
9. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling
10. PKR, apoptosis and cancer
11. The war against the interferon-induced dsRNA-activated protein kinase: Can viruses win?
12. Regulation of the interferon-induced PKR: Can viruses cope?
13. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells
14. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
15. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2
16. The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases
17. Epithelial integrity, cell death and cell loss in mammalian small intestine
18. Apoptosis in small intestinal epithelial from p53-null mice: Evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation
19. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia
20. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
21. Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase
22. Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation
23. PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR
24. PACT, a protein activator of the interferon-induced protein kinase, PKR
25. Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast
26. Specific mutations near the amino terminus of double-stranded RNA-dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties
27. Modular structure of PACT: Distinct domains for binding and activating PKR
28. The intestinal epithelial stem cell: The mucosal governor
29. Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: Investigations of the mechanistic determinants of epithelial apoptosis in vivo
30. Protein phosphorylation in translational control
31. The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans
32. Interferon-induced antiviral actions and their regulation
33. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase
34. Notes from some crypt watchers: Regulation of renewal in the mouse intestinal epithelium
35. Lessons from genetically engineered animal models. VII. Apoptosis in intestinal epithelium: Lessons from transgenic and knockout mice
36. PKR, a sentinel kinase for cellular stress
37. Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation
38. The role of the dsRNA-activated kinase, PKR, in signal transduction
39. Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U 937 cells