Signals that dictate nuclear, nucleolar, and cytoplasmic shuttling of the γ134.5 protein of herpes simplex virus type 1

Journal of Virology

Volumn 76, Issue 18, 2002, Pages 9434-9445

  Cheng, Guofeng ^a   Brett, Marie Elena ^a   He, Bin ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DOUBLE STRANDED RNA; INITIATION FACTOR 2; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE; VIRUS PROTEIN;

ALPHA CHAIN; AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; VIRUS VIRULENCE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEOLUS; CELL NUCLEUS; CYTOPLASM; FATTY ACIDS, UNSATURATED; GENE DELETION; HELA CELLS; HERPESVIRUS 1, HUMAN; HUMANS; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; TRANSFECTION; VIRAL PROTEINS;

EID: 0036720419     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.18.9434-9445.2002     Document Type: Article

References (47)

1. Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome
2. ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures
3. Intrastrain variants of herpes simplex virus type 1 isolated from a neonate with fatal disseminated infection differ in the ICP34.5 gene, glycoprotein processing, and neuroinvasiveness
4. Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2
5. ICP34.5 influences herpes simplex virus type 1 maturation and egress from infected cells in vitro
6. The herpes simplex virus virulence factor ICP34.5 and the cellular protein MvD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34
7. 134.5 protein of herpes simplex virus 1 are required for viral resistance to interferon-α/β
8. 134.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates eIF-2α
9. - mutants of herpes simplex virus 1
10. 134.5, a gene nonessential for growth in culture
11. 134.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells
12. 134.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage
13. The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+
14. The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component
15. Nuclear targeting sequences - A consensus?
16. Status of the ICP34.5 gene in herpes simplex virus type 1 strain 17
17. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
18. Nuclear and nucleolar localization of an African swine fever virus protein, I14L, that is similar to the herpes simplex virus-encoded virulence factor ICP34.5
19. Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis
20. 134.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells
21. 134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells
22. 134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase
23. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
24. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
25. Regulation of a nuclear export signal by an adjacent inhibitory sequence: The effector domain of the influenza virus NS1 protein
26. C23 interacts with B23, a putative nucleolar-localization-signal-binding protein
27. Nucleolar and nuclear localization properties of a herpesvirus bZIP oncoprotein, MEQ
28. Sequence of MyD116 cDNA: A novel myeloid differentiation primary response gene induced by IL6
29. The RL neurovirulence locus in herpes simplex virus type 2 strain HG52 plays no role in latency
30. Functional dissection of the HIV-1 Rev trans-activator-derivation of a trans-dominant repressor of Rev function
31. An N-terminal arginine rich cluster and a proline-alanine-threonine repeat region determines the cellular localization of the herpes simplex virus type-1 ICP34.5 protein and its ligand, protein phosphatase 1
32. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2
33. The herpes simplex virus type 1 strain 17 open reading frame RL1 encodes a polypeptide of apparent M(r) 37K equivalent to ICP34.5 of herpes simplex virus type 1 strain F
34. Characterization of the herpes simplex virus type 1 strain 17+ neurovirulence gene RL1 and its expression in a bacterial system
35. A herpes simplex virus type 1 γ34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals
36. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
37. Functional analysis of the herpes simplex virus type 2 strain HG52 RL1 gene: The intron plays no role in virulence
38. Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing
39. Identification of an export control sequence and a requirement for the KH domains in ICP27 from herpes simplex virus type 1
40. A leucine-rich nuclear export signal, in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
41. The herpes simplex virus type 1 strain 17+ γ34.5 deletion mutant 1716 is avirulent in SCID mice
42. Identification of a signal for rapid export of proteins from the nucleus
43. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated
44. 134.5 deletion mutants in rodent models
45. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
46. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth
47. An African swine fever virus virulence-associated gene NL-S with similarity to the herpes simplex virus ICP34.5 gene