Val193 and Phe195 of the γ134.5 protein of herpes simplex virus 1 are required for viral resistance to interferon-α/β

Virology

Volumn 290, Issue 1, 2001, Pages 115-120

  Cheng, Guofeng ^a   Brett, Marie Elena ^a   He, Bin ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; PHENYLALANINE; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN GAMMA1 34.5; PROTEIN KINASE; UNCLASSIFIED DRUG; VALINE; VIRUS PROTEIN; AMINO ACID; GAMMA 34.5 PROTEIN, HUMAN HERPESVIRUS 1; PROTEIN KINASE R;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; FIBROBLAST; HERPES SIMPLEX VIRUS 1; MOUSE; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS MUTANT; VIRUS REPLICATION; VIRUS RESISTANCE; ANIMAL; ANTIBIOTIC RESISTANCE; BINDING SITE; CERCOPITHECUS; CYTOLOGY; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MOUSE MUTANT; PHYSIOLOGY; VERO CELL;

HERPES; HUMAN HERPESVIRUS 1;

AMINO ACIDS; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; DRUG RESISTANCE, VIRAL; EIF-2 KINASE; FIBROBLASTS; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; MICE; MICE, KNOCKOUT; PHENYLALANINE; VALINE; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0035841360     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.1148     Document Type: Article

References (34)

1. Interferon inhibits herpes simplex virus-specific translation: A reinvestigation
2. Unexpected correlation in the sensitivity of 19 herpes simplex virus strains to types I and II interferons
3. Intrastrain variants of herpes simplex virus type 1 isolated from a neonate with fatal disseminated infection differ in the ICP34.5 gene, glycoprotein processing, and neuroinvasiveness
4. ICP34.5 influences herpes simplex virus type 1 maturation and egress from infected cells in vitro
5. Activation of the ppp(A2′p)nA system in interferon-treated, herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2′p)nA-dependent RNase
6. 134.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates elF-2α
7. - mutants of herpes simplex virus 1
8. 134.5, a gene nonessential for growth in culture
9. The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component
10. The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+
11. 134.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells
12. 134.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage
13. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
14. Specific effect of interferon on the herpes simplex virus type 1 transactivation event
15. 1-interferon genes in human leukemia and derived cell lines
16. 134.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells
17. 134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells
18. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
19. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo
20. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
21. Inhibition of herpes simplex virus type 1 specific translation in cells treated with poly(rl).POLY(RC)
22. 134.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals
23. Herpes simplex virus triggers and then disarms a host antiviral response
24. Herpes simplex virus ICP0 mutants are hypersensitive to interferon
25. The BgIII-N fragment of herpes simplex virus type 2 contains a region responsible for resistance to antiviral effects of interferon
26. Inhibition of herpes simplex virus type 1 immediate-early gene expression by alpha interferon is not VP16 specific
27. Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells
28. Characterization of the early steps of herpes simplex virus replication in interferon-treated human cells
29. Global analysis of herpes simplex virus type 1 transcription using an oligonucleotide-based DNA microarray
30. Mapping the genetic region coding for herpes simplex virus resistance to mouse interferon α/β
31. Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus
32. The comparative anti-herpes simplex virus effects of human interferons
33. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
34. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth