A candidate gene approach within the susceptibility region PCaP on 1q42.2-43 excludes deleterious mutations of the PCTA-1 gene to be responsible for hereditary prostate cancer

European Urology

Volumn 42, Issue 3, 2002, Pages 301-307

  Maier, C ^a   Rosch K ^a   Herkommer, K ^a   Bochum, S ^a   Cancel Tassin, G ^b   Cussenot, O ^b   Haussler J ^a   Assum, G ^a   Vogel, W ^a   Paiss, T ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b Centre de Recherche pour les Pathologies Prostatiques   (France)

Author keywords

Galectin 8; Hereditary prostate cancer; PCaP; PCTA 1

Indexed keywords

PROSTATE CARCINOMA TUMOR ANTIGEN 1; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHROMOSOME 1Q; CONTROLLED STUDY; FAMILIAL CANCER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

GALECTINS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERM-LINE MUTATION; HUMANS; MALE; PEDIGREE; PROSTATIC NEOPLASMS; RISK FACTORS;

EID: 0036718398     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0302-2838(02)00280-4     Document Type: Article

References (44)

1. Hereditary prostate cancer: A study of World War II veteran twins
2. Cancer in twins: Genetic and non-genetic familial risk factors
3. Evidence for autosomal dominant inheritance of prostate cancer
4. Mendelian inheritance of familial prostate cancer
5. Segregation analysis of prostate cancer in Sweden: Support for dominant inheritance
6. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search
7. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36
8. Predisposing gene for early-onset prostate cancer
9. Evidence for a prostate cancer susceptibility locus on the X chromosome
10. Linkage analysis of 153 prostate cancer families over a 30 cM region containing the putative susceptibility locus HPCX
11. Evidence for a prostate cancer-susceptibility locus on chromosome 20
12. A candidate prostate cancer susceptibility gene at chromosome 17p
13. Genetics of prostate cancer: Too many loci, too few genes
14. Germline mutations in the ribonuclease L gene in families showing linkage with HPCI
15. ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer
16. Role of HPC2/ELAC2 in hereditary prostate cancer
17. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer
18. PCAP is the major known prostate cancer predisposing locus in families from south and west Europe
19. Das familiäre prostatakarzinom in Deutschland
20. Galectin-8: A new rat lectin, related to galectin-4
21. Galectin-8: On the road from structure to function
22. Galectins
23. Galectins: A family of animal beta-galactoside-binding lectins
24. Control of galectin gene expression
25. Metastasis of human colon cancer is altered by modifying expression of the beta-galactoside-binding protein galectin 3
26. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
27. Apoptosis of T cells mediated by galectin-1
28. Expression of galectin-3 modulates T-cell growth and apoptosis
29. Galectin-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bc12 family
30. Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin
31. Galectin-7 over-expression is associated with the apoptotic process in UVB-induced sunburn keratinocytes
32. Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells
33. Expression of a specific glycosyl transferase enzyme regulates T-cell death mediated by galectin-1
34. Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis
35. Galectin-8 functions as a matricellular modulator of cell adhesion
36. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigene PCTA-1 a member of the galectin gene family
37. Expression of Po66-CBP, a type-8 galectin, in different healthy tumoral and peritumoral tissues
38. Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous system
39. Down-regulation of beta 1C integrin, an inhibitor of cell proliferation in prostate cancer
40. Regulation of mRNA and protein levels of betal integrin variants in human prostate carcinoma
41. p21 (KIP1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma
42. Mutations in the cystic fibrosis gene in patients with congenital absence of the vas deferens
43. Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA
44. Polyvariant cystic fibrosis transmembrane conductance regulator genes