Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase

Nucleic Acids Research

Volumn 30, Issue 17, 2002, Pages 3778-3787

  Guliaev, Anton B ^a   Hang, Bo ^a   Singer, B ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,N6 ETHENOADENOSINE TRIPHOSPHATE; CARCINOGEN; CHLOROETHYLNITROSOUREA DERIVATIVE; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; EXOCYCLIC DOUBLE BOND;

ARTICLE; CHEMICAL BOND; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DNA ADDUCT; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HUMAN; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

EID: 0036715036     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf494     Document Type: Article

References (31)

1. DNA alkylation by the haloethy1nitrosoureas: Nature of modifications produced and their enzymatic repair or removal
2. Keynote address
3. Etheno DNA-base adducts from endogenous reactive species
4. 4-ethenocytosine by lipid peroxidation products and nucleic acid bases
5. 4-ethenocytosine or 8-oxoguanine
6. 6-ethenoadenine when present in DNA
7. 6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine DNA glycosylase (3-methyladenine DNA glycosylase)
8. 6-ethenoadenine and 3-methyladenine
9. Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase
10. 4-ethenocytosine, a potential product resulting from glycidaldehyde reaction
11. 6-ethano-2′-deoxyadenosine, a metabolic product of 1,3-bis(2-chloroethyl)nitrosourea, and its incorporation into oligomeric DNA
12. 6-ethenoadenine
13. 6-ethenoadenine in a DNA fragment
14. Purification and characterization of human 3-methyladenine-DNA glycosylase
15. Sequence-dependent conformational perturbation in DNA duplexes containing an εA·T mismatch using molecular dynamics simulation
16. VMD-visual molecular dynamics
17. CURVES5. 1
18. 2,3-ethanoguanine from haloethylnitrosourea-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II
19. 6-ethenodeoxyadenosine adduct (εA) opposite deoxyguanosine in a DNA duplex-εA(Syn)-dG(Anti) pairing at the lesion site
20. 6-ethenodeoxyadenosine adduct (εdA) opposite thymidine in a DNA duplex-nonplanar alignment of εdA(Anti) and dT(Anti) at the lesion site
21. Base excision repair enzyme family portrait: Integrating the structure and chemistry of an entire DNA repair pathway
22. DNA repair mechanisms for the recognition and removal of damaged DNA bases
23. What structural features determine repair enzyme specificity and mechanism in chemically modified DNA?
24. 4-ethenocytosine adduct opposite 2′-deoxycytidine: Implications for the recognition of exocyclic lesions by DNA glycosylases
25. Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair
26. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: Mechanisms for nucleotide flipping and base excision
27. Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli
28. Structural basis for the excision repair of alkylation-damaged DNA