Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma IMR32 cells expressing somatostatin receptors

Peptides

Volumn 23, Issue 9, 2002, Pages 1557-1565

  Sun, Lichun ^a   Fuselier, Joseph A ^a   Murphy, William A ^a   Coy, David H ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Human neuroblastoma cell; IMR32; n myc; Oncogene; Peptide nucleic acid (PNA); Somatostatin analog; Somatostatin receptor

Indexed keywords

DC 44 79; DC 46 15; DC 46 17; DC 46 3; DC 46 9; JF 07 69; JF 08 55A; JF 08 55B; JF 08 67; JF 08 69; JF 08 77; JF 08 79; JF 08 83; JF 08 85; JF 09 11; JF 09 49; MESSENGER RNA; PEPTIDE NUCLEIC ACID; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; NEUROBLASTOMA; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA SEQUENCE; TUMOR GROWTH;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL DIVISION; COLORING AGENTS; GROWTH HORMONE; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDE NUCLEIC ACIDS; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RECEPTORS, SOMATOSTATIN; RNA, MESSENGER; SOMATOSTATIN; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0036710005     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(02)00096-7     Document Type: Article

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