Maternal antibody-mediated dyslexia? Evidence for a pathogenic serum factor in a mother of two dyslexic children shown by transfer to mice using behavioural studies and magnetic resonance spectroscopy

Journal of Neuroimmunology

Volumn 130, Issue 1-2, 2002, Pages 243-247

  Vincent, Angela ^a   Deacon, Robert ^a   Dalton, Paola ^a   Salmond, Claire ^a   Blamire, Andrew M ^b   Pendlebury, Sarah ^b   Johansen Berg, Heidi ^a   Rajogopalan, Bheeshma ^b   Styles, Peter ^b   Stein, John ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antibodies; Dyslexia; Magnetic resonance spectroscopy; Maternal to fetal transfer; Mouse behaviour; Neurodevelopmental disorders

Indexed keywords

CHOLINE; CREATININE; FETAL ANTIGEN; MATERNAL ANTIBODY;

ADULT; ARTICLE; BEHAVIOR; BLOOD SAMPLING; CEREBELLUM CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; DYSLEXIA; FAMILY HISTORY; FEMALE; FETUS DEVELOPMENT; FETUS WASTAGE; HUMAN; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOGENESIS; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL; PROGENY; RECURRENT DISEASE; SERUM FACTOR;

ANIMALS; AUTOANTIBODIES; BLOOD PROTEINS; BRAIN; CEREBELLAR ATAXIA; CHILD; DISEASE MODELS, ANIMAL; DYSLEXIA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, MATERNALLY-ACQUIRED; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED STRAINS; MIDDLE AGED; PREGNANCY;

EID: 0036709631     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00226-6     Document Type: Article

References (19)

1. Adinolfi M. Fetal exposure to maternal brain antibodies and neurological handicap. Galaburda A.M. Dyslexia and Development. 1993;155-167 Harvard Univ. Press, Massachusetts.
2. Cardon L.R., Smith S.D., Fulker D.W., Kimberling W.J., Pennington B.F., DeFries J.C. Quantitative trait locus for reading disability. Science. 266:1994;276-279.
3. Crawley J.N. What's Wrong With My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice. 2000;Wiley-Liss, New York.
4. Deacon R.M.J., Bannerman D.M., Kirby B.P., Croucher A., Rawlins J.N.P. Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery. Behav. Brain Res. 133:2002;57-68.
5. Drachman D.B. Myasthenia gravis. New Engl. J. Med. 330:1994;1797-1810.
6. Fawcett A.J., Nicolson R.I., Dean P. Impaired performance of children with dyslexia on a range of cerebellar tasks. Ann. Dyslexia. 46:1996;259-283.
7. Fisher S.E., Marlow A.J., Lamb J., Maestrini E., Williams D.F., Richardson A.J., Weeks D.E., Stein J.F., Monaco A.P. A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia. Am. J. Hum. Genet. 64:1999;146-156.
8. Frahm J., Bruhn H., Gyngell M.L., Merboldt K.D., Hanicke W., Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo. Magn. Reson. Med. 9:1989;79-93.
9. Galaburda A.M. Dyslexia and Development. 1993;Harvard Univ. Press, Cambridge, MA.
10. Guenther K., Deacon R.M., Perry V.H., Rawlins J.N. Early behavioural changes in scrapie-affected mice and the influence of dapsone. Eur. J. Neurosci. 14:2001;401-409.
11. Huh G.S., Boulanger L.M., Du H., Riquelme P.A., Brotz T.M., Shatz C.J. Functional requirement for class I MHC in CNS development and plasticity. Science. 290:2000;2155-2159.
12. Jacobson L., Polizzi A., Morriss-Kay G.M., Vincent A. An animal model of antibody-mediated neurodevelopmental disease: arythrogryposis multiplex congenita caused by antibodies to fetal acetylcholine receptor. J. Clin. Invest. 103:1999;1031-1038.
13. Livingston M.S., Rosen G.D., Drislane F.W., Galaburda A.M. Physiological and anatomical evidence for a magnocellular deficit in developmental dyslexia. Proc. Natl. Acad. Sci. U. S. A. 88:1991;7943-7947.
14. Nicolson R.I., Fawcett A.J., Berry E.L., Jenkins I.H., Dean P., Brooks D.J. Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet. 353:1999;1662-1667.
15. Rae C., Lee M.A., Dixon R.M., Blamire A.M., Thompson C.H., Styles P., Talcott J., Richardson A.J., Stein J.F. Metabolic abnormalities in developmental dyslexia detected by 1H magnetic resonance spectroscopy. Lancet. 351:1998;1849-1852.
16. Riemersma S., Vincent A., Beeson D., Newland C., Hawke S., Vernet-der-Garabedian B., Eymard B. Association of arthrogryposis multiplex congenita with maternal antibodies inhibiting fetal acetylcholine receptor function. J. Clin. Invest. 98:1997;2358-2363.
17. Stein J. The magnocellular theory of developmental dyslexia. Dyslexia. 7:2001;12-36.
18. Stein J.F., Talcott J.B. The magnocellular theory of dyslexia. Dyslexia. 5:1999;59-78.
19. Warren R.P., Cole P., Odell J.D., Pingree C.B., Warren W.L., White E., Yonk J., Singh V.K. Detection of maternal antibodies in infantile autism. J. Am. Acad. Child Adolesc. Psych. 29:1990;873-877.