Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults

Lancet

Volumn 353, Issue 9165, 1999, Pages 1662-1667

  Nicolson, Roderick I ^a,d   Fawcett, Angela J ^a   Berry, Emma L ^a   Jenkins, I Harri ^b   Dean, Paul ^a   Brooks, David J ^b,c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d Western Bank ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN BLOOD FLOW; CEREBELLUM CORTEX; CEREBELLUM DISEASE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DYSLEXIA; FINGER; HUMAN; LEARNING; LEARNING DISORDER; MALE; MOTOR DYSFUNCTION; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0033562441     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(98)09165-X     Document Type: Article

References (35)

1. Report of research group on dyslexia and world illiteracy. World Federation of Neurology: Dallas, TX, USA, 1968.
2. Jorm AF, Share DL, McLean R, Matthews D. Cognitive factors at school entry predictive of specific reading retardation and general reading backwardness: a research note. J Child Psychol Psychiatry 1986; 27: 45-54.
3. Nicolson RI, Fawcett AJ. Comparison of deficits in cognitive and motor skills among children with dyslexia. Ann Dyslexia 1994; 44: 147-64.
4. Bradley L, Bryant PE. Categorising sounds and learning to read: a causal connection. Nature 1983; 301: 419-21.
5. Stanovich KE. Explaining the differences between the dyslexic and the garden-variety poor reader: the phonological-core variable-difference model. Ann Dyslexia 1988; 38: 154-77.
6. Rudel RG. The definition of dyslexia: language and motor deficits. In: Duffy FH, Geschwind N, eds. Dyslexia: a neuroscientific approach to clinical evaluation. Boston: Little Brown, 1985: 33-53.
7. Wolff P, Michel GF, Ovrut M, Drake C. Rate and timing precision of motor coordination in developmental dyslexia. Dev Psychol 1990; 26: 349-59.
8. Nicolson RI, Fawcett AJ. Automaticity: a new framework for dyslexia research? Cognition 1990; 35: 159-82.
9. Yap RL, Van der Leij A. Testing the automatization deficit hypothesis of dyslexia via a dual task paradigm. J Learn Disabil 1994; 27: 60-65.
10. Wolf M. Naming speed and reading: the contribution of the cognitive neurosciences. Read Res Quart 1991; 26: 123-41.
11. Nicolson RI, Fawcett AJ. Reaction times and dyslexia. Q J Exp Psychol 1994; 47A: 29-48.
12. Holmes G. The cerebellum of man. Brain 1917; 40: 461-535.
13. Eccles JC, Ito M, Szentagothai J. The cerebellum as a neuronal machine. New York: Springer-Verlag, 1967.
14. Ito M. A new physiological concept on cerebellum. Rev Neurol 1990; 146: 564-69.
15. Frank J, Levinson HN. Dysmetria, dyslexia and dyspraxia: hypothesis and study. J Am Acad Child Psychiatry 1973; 12: 690-701.
16. Leiner HC, Leiner AL, Dow RS. Reappraising the cerebellum: what does the hindbrain contribute to the forebrain? Trends Neurosci 1993; 16: 444-47.
17. Paulesu E, Frith CD, Frackowiak RSJ. The neural correlates of the verbal component of working memory. Nature 1993; 362: 342-45.
18. Akshoomoff NA, Courchesne E. A new role for the cerebellum in cognitive operations. Behav Neurosci 1992; 106: 731-38.
19. Allen G, Buxton RB, Wong EC, Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science 1997; 275: 1940-43.
20. Silveri MC, Leggio MG, Molinari M. The cerebellum contributes to linguistic production: a case of agrammatic speech following a right cerebellar lesion. Neurology 1994; 44: 2047-50.
21. Nicolson RI, Fawcett AJ, Dean P. Time estimation deficits in developmental dyslexia: evidence for cerebellar involvement. Proc Roy Soc B Biol Sci London 1995; 259: 43-47.
22. Ivry RB, Keele SW. Timing functions of the cerebellum. J Cogn Neurosci 1989; 1: 136-52.
23. Fawcett AJ, Nicolson RI, Dean P. Impaired performance of children with dyslexia on a range of cerebellar tasks. Ann Dyslexia 1996; 46: 259-83.
24. Dow RS, Moruzzi G. The physiology and pathology of the cerebellum. Minneapolis: University of Minnesota Press, 1958.
25. 1H magnetic resonance spectroscopy. Lancet 1998; 351: 1849-52.
26. Eden GF, Vanmeter JW, Rumsey JM, Maisog JM, Woods RP, Zeffiro TA. Abnormal processing of visual-motion in dyslexia revealed by functional brain imaging. Nature 1996; 382: 6-69.
27. Paulesu E, Frith U, Snowling M, et al. Is developmental dyslexia a disconnection syndrome - evidence from PET scanning. Brain 1996; 119: 143-57.
28. Jenkins IH, Brooks DJ, Nixon PD, Frackowiak RSJ, Passingham RE. Motor sequence learning - a study with positron emission tomography. JNeurosci 1994; 14: 3775-90.
29. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd edn, revised. Washington DC: American Psychiatric Association, 1987.
30. The Wellcome department of cognitive neurology. Statistical parametric mapping SPM96. London: Wellcome Institute, 1996.
31. Friston KJ, Holmes AP, Worley KJ, Poline J-B, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional brain mapping: a general linear approach. Hum Brain Mapp 1995; 5: 189-210.
32. Fawcett AJ, Nicolson RI. Speed of processing, motor skill, automaticity and dyslexia. In: Fawcett AJ, Nicolson RI, eds. Dyslexia in children: multidisciplinary perspectives. Hemel Hempstead: Harvester Wheatsheaf, 1994.
33. Evans AC, Collins DL, Mills SR, Brown RD, Kelly RL, Peters TM. 3D statistical neuroanatomical models from 305 MRI volumes. In: Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference, 1993: 1813-17.
34. Talairach J, Tournaux P. Co-planar sterotaxic atlas of the human brain. New York: Thiéme, 1988.
35. Fawcett AJ, Nicolson RI. Performance of dyslexic children on cognitive and cerebellar tests. J Mot Behavior 1999; 31: 68-78.