Immune pathogenesis of multiple sclerosis. Brain autoimmune reactivity and its control by neuronal function

Multiple Sclerosis

Volumn 4, Issue 3, 1998, Pages 136-137

  Wekerle, Hartmut ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

Autoantigens; Multiple sclerosis; T cells; Tlymphocytes

Indexed keywords

ENCEPHALITOGENIC PROTEIN; MYELIN;

ARTICLE; AUTOIMMUNE DISEASE; BRAIN; BRAIN DISEASE; CEREBROSPINAL FLUID; CONTROL SYSTEM; HUMAN; MULTIPLE SCLEROSIS; NERVE CELL; NERVE CELL DEGENERATION; T LYMPHOCYTE;

EID: 0031656947     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245859800400309     Document Type: Article

References (17)

1. Ebers GC, Sadovnick AD. (1994) The role of genetic factors in multiple sclerosis susceptibility. J Neuroimmunol 54: 1-17.
2. Lassman H, Vass K. (1995) Are current immunological concepts of multiple sclerosis reflected by the immunopathology of its lesions? Springer Semin Immunopathol 17: 77-87.
3. Wekerle H et al. (1994) Animal models. Ann Neurol 36: S47-S53.
4. Wekerle H et al. (1996) The shaping of the brain-specific T lymphocyte repertoire in the thymus. Immunol Rev 149: 231-243.
5. Hafler DA et al. (1996) TCR usage in human and experimental demyelinating disease. Immunol Today 17: 152-159.
6. Wekerle H. (1992) Myelin specific, autoaggressive T cell clones in the normal immune repertoire: Their nature and their regulation. Int Rev Immunol 9: 231-241.
7. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16:
8. Hickey WF. (1991) Migration of hematogenous cells through the blood-brain barrier and the initiation of CNs inflammation. Brain Pathol 1: 97-106.
9. + T cells specific for an astrocyte protein, S100b. J Neural Transm 49 Supplementum: 43-51.
10. Bernard CCA et al. (1997) Myelin oligodendrocyte glycoprotein: A novel candidate autoantigen in multiple sclerosis. J Mol Med 75: 77-88.
11. Genain CP et al. (1994) In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J Clin Invest 94: 1339-1345.
12. Meinl E et al. (1997) Encephalitogenic potential of myelin basic protein-specific T cells isolated from normal rhesus macaques. Am J Pathol 150: 445-453.
13. Neumann H, Wekerle H. (1998) Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration. J Neuropathol Exp Neurol 58: 1-9.
14. Neumann H et al. (1996) Neuronal control of MHC class II inducibility in rat astrocytes and microglia. Eur J Neurosci 8: 2582-2590.
15. Neumann H, Cavalié A, Jenne DE, Wekerle H (1995) Induction of MHC class I genes in neurons. Science 269: 549-552.
16. Neumann H et al. (1997) MHC class I gene expression in single neurons of the central nervous system: Differential regulation by interferon-γ and tumor necrosis factor-α. J Exp Med 185: 305-316.
17. Trapp BD et al. (1998) Axonal transection in the lesion of multiple sclerosis. N Engl J Med 338: 278-285.