Activation of protein kinase A during human sperm capacitation and acrosome reaction

Journal of Andrology

Volumn 23, Issue 5, 2002, Pages 709-716

  Lefièvre, Linda ^a   Jha, Kula N ^a   De Lamirande, Eve ^a   Visconti, Pablo E ^a   Gagnon, Claude ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Calcium ionophore A23187; Cyclic adenosine monophosphate; Phosphodiesterases; Signal transduction

Indexed keywords

CALCIMYCIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; IONOPHORE; PHOSPHODIESTERASE;

ACROSOME REACTION; ARTICLE; CELL FRACTIONATION; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; INTRACELLULAR MEMBRANE; MALE; METABOLISM; PHYSIOLOGY; SPERMATOZOON; SPERMATOZOON CAPACITATION; TISSUE DISTRIBUTION; CONTROLLED STUDY; HUMAN CELL; MOLECULAR DYNAMICS; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACROSOME REACTION; CALCIMYCIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; HUMANS; INTRACELLULAR MEMBRANES; IONOPHORES; MALE; PHOSPHORIC DIESTER HYDROLASES; SPERM CAPACITATION; SPERMATOZOA; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION; HUMAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0036708433     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. The culture of mouse embryos in vitro
2. Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals
3. Correlation between intracellular cAMP content, kinematic parameters and hyperactivation of human spermatozoa after incubation with pentoxifylline
4. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor
5. Two simple methods for detecting the acrosome reaction of human sperm
6. Modulation of human sperm acrosome reaction by effectors of the adenylate cyclase/cAMP second messenger pathway
7. Involvement of reactive oxygen species in human sperm acrosome reaction induced by A23187, lysophosphatidylcholine, and biological fluid ultrafiltrates
8. Human sperm hyperactivation and capacitation as parts of an oxidative process
9. Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization
10. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
11. The biological functions of A-kinase anchor proteins
12. Enhancement of motility and acrosome reaction in human spermatozoa: Differential activation by type-specific phosphodiesterase inhibitors
13. A molecular mechanism for long-term sensitization in Aplysia
14. Regulatory subunits of cAMP-dependent protein kinase are degraded after conjugation to ubiquitin: A molecular mechanism underlying long-term synaptic plasticity
15. Calcium-dependent increase in adenosine 3′, 5′-monophosphate and induction of the acrosome reaction in guinea pig spermatozoa
16. Cyclic adenosine 3′, 5′-monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility
17. The cyclic GMP-specific phosphodiesterase inhibitor, sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction
18. Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa
19. Lowered levels of bicarbonate in seminal plasma cause the poor sperm motility in human infertile patients
20. Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase
21. ++-dependent 3′, 5′-cyclic adenosine monophosphate increase in human sperm
22. Differential localization of two isoforms of the regulatory subunit RIIα of cAMP-dependent protein kinase in human sperm: Biochemical and cytochemical study
23. Difference in the role of cyclic adenosine 3′, 5′-monophosphate during capacitation of bovine sperm by heparin or oviduct fluid
24. Signaling through scaffold, anchoring, and adaptor proteins
25. Regulation of cyclic adenosine monophosphate synthesis in human ejaculated spermatozoa. II. The role of calcium and bicarbonate ions on the activation of adenylyl cyclase
26. Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA
27. Identification, quantification, and cellular localization of PDE calmodulin-stimulated cyclic nucleotide phosphodiesterase
28. Calcium mobilization and influx during sperm exocytosis
29. Cyclic nucleotide metabolism in mouse epididymal spermatozoa during capacitation in vitro
30. The spermatozoon as a machine: Compartmentalized metabolic and signaling pathways bridge cellular structure and function
31. Subcellular localization of the regulatory subunits of cyclic adenosine 3′, 5′monophosphate-dependent protein kinase in bovine spermatozoa
32. Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation
33. Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by cAMP-dependent pathway
34. Novel signaling pathways involved in sperm acquisition of fertilizing capacity
35. Mammalian fertilization
36. The transcriptional activity of NFkappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism