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Volumn 17, Issue 1, 1999, Pages 75-86

MET-88: SR Ca2+-uptake stimulator for treating chronic heart failure

Author keywords

Glycolysis; MET 88; Myocardial energy metabolism; Myocardial function; Remodeling; SR Ca2+ uptake

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); MILDRONATE;

EID: 0032796642     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.1999.tb00005.x     Document Type: Review
Times cited : (3)

References (24)
  • 1
    • 0030723182 scopus 로고    scopus 로고
    • Inhibition of carnitine synthesis protects against left ventricular dysfunction in rats with myocardial ischemia
    • Aoyagi T, Sugiura S, Eto Y, Yonekura K, et al. Inhibition of carnitine synthesis protects against left ventricular dysfunction in rats with myocardial ischemia. J Cardiovasc Pharmacol 1997;30:468-474.
    • (1997) J Cardiovasc Pharmacol , vol.30 , pp. 468-474
    • Aoyagi, T.1    Sugiura, S.2    Eto, Y.3    Yonekura, K.4
  • 2
    • 0031978533 scopus 로고    scopus 로고
    • Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts
    • Asaka N, Muranaka Y, Kirimoto T, et al. Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts. Fundam Clin Pharmacol 1998;12: 158-163.
    • (1998) Fundam Clin Pharmacol , vol.12 , pp. 158-163
    • Asaka, N.1    Muranaka, Y.2    Kirimoto, T.3
  • 3
    • 0007702358 scopus 로고
    • Cardioprotective profile of MET-88 in isolated perfused rat hearts
    • Asaka N, Muranaka Y, Kirimoto T, et al. Cardioprotective profile of MET-88 in isolated perfused rat hearts. Eur Heart J 1994;93(Suppl):93.
    • (1994) Eur Heart J , vol.93 , Issue.SUPPL. , pp. 93
    • Asaka, N.1    Muranaka, Y.2    Kirimoto, T.3
  • 4
    • 0000707075 scopus 로고    scopus 로고
    • Reduction of carnitine content by inhibition of its biosynthesis results in protection of isolated guinea pig hearts against hypoxic damage
    • Dahr PK, Grupp IL, Schwartz A, et al. Reduction of carnitine content by inhibition of its biosynthesis results in protection of isolated guinea pig hearts against hypoxic damage. J Cardiovasc Pharmacol Ther 1996; 1:235-242.
    • (1996) J Cardiovasc Pharmacol Ther , vol.1 , pp. 235-242
    • Dahr, P.K.1    Grupp, I.L.2    Schwartz, A.3
  • 5
    • 85047676023 scopus 로고
    • Simple, rapid, and effective method of producing aortocaval shunts in the rat
    • Garcia R, Diebold S. Simple, rapid, and effective method of producing aortocaval shunts in the rat. Cardiovasc Res 1990;24:430-432.
    • (1990) Cardiovasc Res , vol.24 , pp. 430-432
    • Garcia, R.1    Diebold, S.2
  • 6
    • 0031005481 scopus 로고    scopus 로고
    • Calcium handling proteins in the failing human heart
    • Hasenfuss G, Meyer M, Schillinger W, et al. Calcium handling proteins in the failing human heart. Basic Res Cardiol 1997;92(Suppl I):87-93.
    • (1997) Basic Res Cardiol , vol.92 , Issue.SUPPL. I , pp. 87-93
    • Hasenfuss, G.1    Meyer, M.2    Schillinger, W.3
  • 7
    • 0028101383 scopus 로고
    • 2+-ATPase in failing and nonfailing human myocardium
    • 2+-ATPase in failing and nonfailing human myocardium. Circ Res 1994;75:434-442.
    • (1994) Circ Res , vol.75 , pp. 434-442
    • Hasenfuss, G.1    Reinecke, H.2    Studer, R.3
  • 8
    • 0021339632 scopus 로고
    • Positive inotropic effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212) in the dog with experimentally-induced right-sided heart failure
    • Hashimoto K, Yabuuchi Y, Yamashita S, et al. Positive inotropic effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212) in the dog with experimentally-induced right-sided heart failure. Arzneim Forsh Drug Res 1984;34:390-393.
    • (1984) Arzneim Forsh Drug Res , vol.34 , pp. 390-393
    • Hashimoto, K.1    Yabuuchi, Y.2    Yamashita, S.3
  • 9
    • 0008039589 scopus 로고
    • Beneficial effects of MET-88, a new cardioprotective agent, on ventricular remodeling in rats with chronic heart failure secondary to myocardial infarction
    • Hayashi Y, Kirimoto T, Asaka N, et al. Beneficial effects of MET-88, a new cardioprotective agent, on ventricular remodeling in rats with chronic heart failure secondary to myocardial infarction. Jpn J Pharmacol 1995;67(Suppl I):P1-156.
    • (1995) Jpn J Pharmacol , vol.67 , Issue.SUPPL. I
    • Hayashi, Y.1    Kirimoto, T.2    Asaka, N.3
  • 10
    • 85047678642 scopus 로고
    • Modified technique for production of experimental right-sided congestive failure
    • Higgins CB, Pavelec R, Vatner SF. Modified technique for production of experimental right-sided congestive failure. Cardiovasc Res 1973;7:870-874.
    • (1973) Cardiovasc Res , vol.7 , pp. 870-874
    • Higgins, C.B.1    Pavelec, R.2    Vatner, S.F.3
  • 11
    • 0026587014 scopus 로고
    • Relation between glycolysis and calcium homeostasis in postischemic myocardium
    • Jeremy RW, Koretsune Y, Marban E, et al. Relation between glycolysis and calcium homeostasis in postischemic myocardium. Circ Res 1992;70:1180-1190.
    • (1992) Circ Res , vol.70 , pp. 1180-1190
    • Jeremy, R.W.1    Koretsune, Y.2    Marban, E.3
  • 12
    • 84910705812 scopus 로고
    • Experimental myocardial infarction: I. A method of coronary occlusion in small animals
    • Johns TNP, Olson BJ. Experimental myocardial infarction: I. A method of coronary occlusion in small animals. Ann Surg 1954;5:140.
    • (1954) Ann Surg , vol.5 , pp. 140
    • Johns, T.N.P.1    Olson, B.J.2
  • 13
    • 0345509691 scopus 로고    scopus 로고
    • The beneficial effects of MET-88 on cardiac hypertrophy by monocrotaline in rats
    • Kirimoto T, Asaka N, Hayashi Y, et al. The beneficial effects of MET-88 on cardiac hypertrophy by monocrotaline in rats. Jpn J Pharmacol 1997;73(Suppl I):132.
    • (1997) Jpn J Pharmacol , vol.73 , Issue.SUPPL. I , pp. 132
    • Kirimoto, T.1    Asaka, N.2    Hayashi, Y.3
  • 14
    • 23544445723 scopus 로고
    • MET-88, a new cardioprotective agent, improves experimentally induced heart failure in dogs
    • Kirimoto T, Hayashi Y, Miyake H, et al. MET-88, a new cardioprotective agent, improves experimentally induced heart failure in dogs. Jpn J Pharmacol 1995;67(Suppl I):S33-6.
    • (1995) Jpn J Pharmacol , vol.67 , Issue.SUPPL. I
    • Kirimoto, T.1    Hayashi, Y.2    Miyake, H.3
  • 15
    • 23544470780 scopus 로고    scopus 로고
    • The beneficial effects of MET-88 on changes in myocardial pH and infarct size during coronary artery occlusion and reperfusion in dogs
    • Kirimoto T, Hayashi Y, Miyake H, et al. The beneficial effects of MET-88 on changes in myocardial pH and infarct size during coronary artery occlusion and reperfusion in dogs. Jpn J Pharmacol 1996;71(Suppl I):P-349.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.SUPPL. I
    • Kirimoto, T.1    Hayashi, Y.2    Miyake, H.3
  • 16
    • 0029836940 scopus 로고    scopus 로고
    • Beneficial effect of MET-88, γ-butyrobetaine hydroxylase inhibitor, or energy metabolism in ischemic dog hearts
    • Kirimoto T, Nobori N, Asaka N, et al. Beneficial effect of MET-88, γ-butyrobetaine hydroxylase inhibitor, or energy metabolism in ischemic dog hearts. Arch Int Pharmacodyn Ther 1996;331:163-178.
    • (1996) Arch Int Pharmacodyn Ther , vol.331 , pp. 163-178
    • Kirimoto, T.1    Nobori, N.2    Asaka, N.3
  • 17
    • 85047678834 scopus 로고
    • On the possible role of long chain acylcarnitine accumulation in producing functional and calcium permeability changes in membranes during myocardial ischemia
    • Lamers JMJ, Jonge-Stinis JT, Verdouw PD, et al. On the possible role of long chain acylcarnitine accumulation in producing functional and calcium permeability changes in membranes during myocardial ischemia. Cardiovasc Res 1987;21:313-322.
    • (1987) Cardiovasc Res , vol.21 , pp. 313-322
    • Lamers, J.M.J.1    Jonge-Stinis, J.T.2    Verdouw, P.D.3
  • 18
    • 85047669725 scopus 로고    scopus 로고
    • Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts
    • Linck B, Eschenhage T, Scholz H, et al. Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts. Cardiovasc Res 1996;31: 625-632.
    • (1996) Cardiovasc Res , vol.31 , pp. 625-632
    • Linck, B.1    Eschenhage, T.2    Scholz, H.3
  • 19
    • 0024358286 scopus 로고
    • Response of isolated working hearts to fatty acids and carnitine palmitoyltransferase I inhibition during reduction of coronary flow in acutely and chronically diabetic rats
    • Lopaschuk GD, Spafford M. Response of isolated working hearts to fatty acids and carnitine palmitoyltransferase I inhibition during reduction of coronary flow in acutely and chronically diabetic rats. Circ Res 1989;65:378-387.
    • (1989) Circ Res , vol.65 , pp. 378-387
    • Lopaschuk, G.D.1    Spafford, M.2
  • 20
    • 0024262853 scopus 로고
    • Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine
    • Lopaschuk GD, Wall SR, Olley PM, et al. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res 1988;63:1036-1043.
    • (1988) Circ Res , vol.63 , pp. 1036-1043
    • Lopaschuk, G.D.1    Wall, S.R.2    Olley, P.M.3
  • 21
    • 0345078131 scopus 로고    scopus 로고
    • The beneficial effects of MET-88 on cardiac hypertrophy with volume overload in rats
    • Nakano M, Kirimoto T, Asaka N, et al. The beneficial effects of MET-88 on cardiac hypertrophy with volume overload in rats. Jpn J Pharmacol 1996;71(Suppl I):135.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.SUPPL. I , pp. 135
    • Nakano, M.1    Kirimoto, T.2    Asaka, N.3
  • 22
    • 84961058932 scopus 로고
    • Simple techniques for the surgical occlusion of coronary vessels in the rat
    • Selye H, Bajusz E, Grasso S, et al. Simple techniques for the surgical occlusion of coronary vessels in the rat. Angiology 1960;11:398.
    • (1960) Angiology , vol.11 , pp. 398
    • Selye, H.1    Bajusz, E.2    Grasso, S.3
  • 23
    • 0023853252 scopus 로고
    • 3-(2,2,2-Trimethylhydrazinium) propionate (THP): A novel γ-butyrobetaine hydroxylase inhibitor with cardioprotective properties
    • Simkhovich B, Shutenko Z, Meirena D, et al. 3-(2,2,2-Trimethylhydrazinium) propionate (THP): a novel γ-butyrobetaine hydroxylase inhibitor with cardioprotective properties. Biochem Pharmacol 1987;37:195-202.
    • (1987) Biochem Pharmacol , vol.37 , pp. 195-202
    • Simkhovich, B.1    Shutenko, Z.2    Meirena, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.