Defective activation of p21ras in peripheral blood mononuclear cells from patients with insulin dependent diabetes mellitus

Autoimmunity

Volumn 29, Issue 2, 1999, Pages 147-154

  Rapoport, Micha J ^b   Mor, Anat ^c   Vardi, Pnina ^a   Ramot, Yoram ^c   Levi, Ofer ^c   Bistritzer, Tzvy ^c  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b ASSAF HAROFEH MEDICAL CENTER   (Israel)

^c NONE

Author keywords

Diabetes; Human; Oncogenes; Signal transduction

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INSULIN; PHYTOHEMAGGLUTININ; PROTEIN P21; RAS PROTEIN; RELEASING FACTOR; T LYMPHOCYTE RECEPTOR;

ADULT; AGE; AGED; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; GENDER; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; METABOLIC REGULATION; MONONUCLEAR CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTO ONCOGENE; T LYMPHOCYTE;

EID: 0032959710     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908995385     Document Type: Article

References (19)

1. Pawson, T. Protein modules and signaling networks. Nature 1995; 373: 573-580.
2. Grand, R.J. and Owen, D. The biochemistry of ras p21. Biochem. J. 1991; 279: 609-631.
3. ras during T-cell activation and growth. Immunol. Today 1995; 16: 159-164.
4. Castano, L. and Eisenbarth, G.S. Type-I diabetes: a chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol. 1990; 8: 647-679.
5. Rapoport, M.J., Lazarus, A.H., Jaramillo, A., Speck, E. and Delovitch, T.L. Thymic T cell anergy in autoimmune non-obese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation. J. Exp. Med. 1993; 177: 1221-1226.
6. Giordano, C., De Maria, R., Todaro, M., Stassi, G., Mattina, A., Richiusa, P. et al. Study of T-cell activation in Type I diabetic patients and pre-Type I diabetic subjects by cytomeric analysis: antigen expression defect in vitro. J. Clin. Immunol. 1993; 13: 68-78.
7. Faustman, D., Li, X.P., Lin, H.Y., Fu, Y.E., Eisenbarth, G., Avruch, J. et al. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science 1991; 254: 1756-1761.
8. De Maria, R., Todaro, M., Stassi, G., Di Blasi, F., Giordano, M., Galluzzo, A. et al. Defective T cell receptor/CD3 complex signaling in human type I diabetes. Eur. J. Immunol. 1994; 24: 999-1002.
9. Rapoport, M.J., Weiss, L., Mor, A., Bistritzer, T., Ramot, Y. and Slavin, S. Prevention of autoimmune diabetes by Linomide in NOD mice is associated with upregulation of the T cell receptor mediated activation of p21ras. J. Immunol. 1996; 157: 4721-4725.
10. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979; 28: 1039-1057.
11. Graves, J.D., Lucas, S.C., Alexander, D.R. and Cantrell, D.A. Guanine nucleotide regulation of inositol phospholipid hydrolysis and CD3-antigen phosphorylation in permeabilized T lymphocytes. Biochem. J. 1990; 265: 407-413.
12. Kahn, C.R. Insulin action, diabetogenes, and the cause of Type II diabetes. Diabetes 1994; 43: 1066-1084.
13. Reynet, C. and Kahn, C.R. RAD: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science 1993; 262, 1441-1444.
14. Rapoport, M.J., Jaramillo, A., Zipris, D., Lazarus, A.H., Serreze, D.V., Leiter, E.H. et al. Interleukin 4 reverses Tcell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 1993; 178: 87-99.
15. Zipris, D., Lazarus, A.H., Crow, A.R., Haddzija, M. and Delovitch, T.L. Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune non-obese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis. J. Immunol. 1991; 146: 3763-3771.
16. Brugering, B.M.T., Medema, R.H., Maassen, J.A., van de Wetering, M.L., van der Eb, A.J., McCormick, F. et al. Insulin stimultaion of gene expression mediated by p21 ras activation. EMBO J. 1991; 10: 1103-1109.
17. ras/mitogen-activated protein kinase in Nb2-llC rat lymphoma cells. Endocrine 1996; 4: 65-71.
18. Herman, M.A., Sandborg, C.I. and Wang, Z. Decreased IL-4 production in new onset Type I insulin dependent diabetes mellitus. J. Immunol. 1996; 157: 4690-4696.
19. Rapoport, M.J., Mor, A., Bistritzer,T., Ramot, Y., Levi, O., Slavin, S. et al. Protooncogenes and autoimmunity. Isr J. Med. Sci. 1997; 4: 262-266.