Lead exposure affects levels of galactolipid metabolic enzymes in the developing rat brain

Toxicology and Applied Pharmacology

Volumn 172, Issue 2, 2001, Pages 98-107

  Deng, Wenbin ^a   Poretz, R D ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Arylsulfatase A; Galactocerebroside; Lead toxicity; Myelin; Oligodendrocyte; Sulfatide

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; GALACTOLIPID; LEAD; LIPID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; FETUS; LEAD POISONING; LIPID BLOOD LEVEL; MYELINATION; NEUROTOXICITY; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRENATAL EXPOSURE; RAT; STEM CELL; TOXICITY TESTING;

EID: 0035870819     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9142     Document Type: Article

References (44)

1. Effects of low level lead exposure on cognitive function in children: A review of behavioral, neuropsychological and biological evidence
2. Developmental expression of 2′,3′-cyclic nucleotide 3′-phosphohydrolase in dissociated fetal rat brain cultures and rat brain
3. Frequency of arylsulfatase A pseudodeficiency associated mutations in a healthy population
4. The assay of aryisulfatase A and B in human urine
5. Neurodevelopmental effects of low-level lead exposure in children
6. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis
7. Lead levels in exposed herring gulls: Difference in the field and laboratory
8. Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability
9. New perspectives on the function of myelin galactolipids
10. Partial enzyme deficiencies: Residual activities and the development of neurological disorders
11. Biochemical basis of late-onset neurolipidosis
12. Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions
13. Hydroxy- and non-hydroxy-galactolipids in developing rat CNS
14. Toxic myelinopathies
15. Arylsulfatase A pseudodeficiency: Loss of a polyadenylation signal and N-glycosylation site
16. Effect of chelation with meso-dimercaptusuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat
17. Lead toxicity: Current concerns
18. Chemistry and functional distribution of sulfoglycolipids
19. Metachromatic leukodystrophy caused by a partial cerebroside sulfatase deficiency
20. Metachromatic leukodystrophy and multiple sulfatase deficiency: Sulfatide lipidosis
21. Lead encephalopathy in the developing rat: Effect upon myelination
22. 2′,3′-Cyclic nucleotide 3′-phosphohydrolase in brains of mutant mice with deficient myelination
23. Lead poisoning
24. A simple chromogenic assay for arylsulfatase A
25. Quantitative correlation between the residual activity of beta-hexosaminidase A and arylsulfatase A and the severity of the resulting lysosomal storage
26. Protein measurement with the Folin phenol reagent
27. Blood lead levels among children - Rhode Island, 1993-1995
28. UDP-galactose: Ceramide galactosyltransferase from rat brain
29. The oligodendrocyte and its many cellular processes
30. The interaction of lead exposure and arylsulfatase A genotype affects sulfatide catabolism in human fibroblasts
31. Chronic exposure to lead acetate affects the development of protein kinase C activity and the distribution of the PKCγ isozyme in the rat hippocampus
32. Childhood lead poisoning in China
33. 2′,3′-Cyclic NADP as a substrate for 2′,3′-cyclic nucleotide 3′-phosphohydrolase
34. Chronic lead intoxication: Effects on developing optic nerve
35. Lead toxicity in neuroglia
36. Effect of inorganic lead exposure on myelination in rat
37. Galactocerebroside sulfatransferase, arylsulfatase A and cerebroside sulfatase activity in different regions of developing rat brain
38. Developmental profiles of arylsulfatase A and B in rat cerebral cortex and spinal cord
39. Metabolic and functional aspects of sulfogalactolipids
40. Pseudodeficiency of arylsulfatase A and galactocerebrosidase activities
41. Homogeneity of regional brain lead concentrations
42. Prenatal diagnosis of Krabbe disease using a fluorescence derivative of galactocerebroside