Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue

Biochemical Journal

Volumn 365, Issue 3, 2002, Pages 809-816

  Saysell, Colin G ^a   Tambyrajah, Winston S ^a   Murray, Jeremy M ^a   Wilmot, Carrie M ^a   Phillips, Simon E V ^a   McPherson, Michael J ^a   Knowles, Peter F ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Copper; Hydrazines; Inhibition; Topa quinone; Tranylcypromine

Indexed keywords

AMINES; CATALYSIS; ESCHERICHIA COLI; MONOMERS; PH EFFECTS; SUBSTRATES;

BINDING CONSTANTS;

ENZYMES;

AMINE OXIDASE (FLAVIN CONTAINING); HYDRAZINE DERIVATIVE; QUINONE DERIVATIVE; SCHIFF BASE; TRANYLCYPROMINE;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTON TRANSPORT; STEADY STATE;

AMINE OXIDASE (COPPER-CONTAINING); BINDING SITES; CATALYSIS; COENZYMES; DIHYDROXYPHENYLALANINE; ENZYME INHIBITORS; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; MUTATION; PHENETHYLAMINES; PROTEIN BINDING; TRANYLCYPROMINE;

ESCHERICHIA COLI;

EID: 0036685346     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20011435     Document Type: Article

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